ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Increase in human skeletal muscle lactate produced by fenfluramine (1976)

KIRBY, MARILYN J. ; TURNER, P.

[s.l.] : Nature Publishing Group

Nature 262 (1976), S. 617-617

add to mindlist on the mindlist

Details

ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Human skeletal muscle was obtained at surgery for total hip joint replacement. The preparation and incubation of the tissue (in Krebs-bicarbonate buffer with added bovine serum albumin Imgrnl-1 and glucose 16.67 x 10?3 M) was carried out using the method of Kirby, Leighton and Turner5. Muscle ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/262617a0

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Clinical pharmacological studies of tandamine, a potential antidepressive drug (1977)

Ehsanullah, Raihana S. B. ; Ghose, Karabi ; Kirby, Marilyn J. ; [et al.]

Springer

Psychopharmacology 52 (1977), S. 73-77

add to mindlist on the mindlist

Details

ISSN: 1432-2072

Keywords: Tandamine ; Tyramine pressor response ; Anticholinergic ; Appetite ; Sedation ; Depression ; Platelet ; Plasma concentration ; Monoamines

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.