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  • Artikel: DFG Deutsche Nationallizenzen  (22)
  • 1995-1999  (22)
  • 1960-1964
  • 1955-1959
  • 1995  (22)
  • 11
    ISSN: 1432-0533
    Schlagwort(e): Adult T cell leukemia ; HTLV-I ; Immunohistochemistry ; In situ polymerase chain reaction ; p53 protein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report the pathological changes in skeletal muscle from a patient with acute adult T cell leukemia (ATL). HTLV-I provirus was detected in infiltrating cells using in situ polymerase chain reaction in frozen sections. Furthermore, aberrant expression of the p53 protein was observed in the infiltrating cells. As p53 protein was not observed in mononuclear inflammatory cells in patients with polymyositis, expression of the p53 protein was considered to be one of the characteristic findings in ATL cells. This is the first direct detection of ATL cells in skeletal muscle.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 12
    ISSN: 1432-0533
    Schlagwort(e): Key words Adult T cell leukemia ; HTLV-I ; Immunohistochemistry ; In situ polymerase chain reaction ; p53 protein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report the pathological changes in skeletal muscle from a patient with acute adult T cell leukemia (ATL). HTLV-I provirus was detected in infiltrating cells using in situ polymerase chain reaction in frozen sections. Furthermore, aberrant expression of the p53 protein was observed in the infiltrating cells. As p53 protein was not observed in mononuclear inflammatory cells in patients with polymyositis, expression of the p53 protein was considered to be one of the characteristic findings in ATL cells. This is the first direct detection of ATL cells in skeletal muscle.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 13
    Digitale Medien
    Digitale Medien
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 41 (Feb. 1995), p. 215-224 
    ISSN: 1662-9779
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Physik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 14
    Digitale Medien
    Digitale Medien
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 41 (Feb. 1995), p. 285-292 
    ISSN: 1662-9779
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Physik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 15
    ISSN: 1432-0630
    Schlagwort(e): 68.35 ; 81.10
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract C70 single crystals, free from solvent contamination, were grown via vapor phase transport technique. The (0001) face of the C70 crystal was imaged with Atomic Force Microscopy (AFM) under ambient atmosphere. Low-resolution images of a freshly prepared crystal revealed well-ordered faceted regions with multiple terraces extending over a region of several hundred square nanometers. The terraced structure in the images indicates that the crystals formed as a layer growth. In the high-resolution images, C70 molecules were resolved in a hexagonal close packed (hcp) structure with an average center-to-center distance of 10.5±0.5 Å. After one month's exposure to the ambient atmosphere, the molecules rearranged into a mixed structure consisting of hcp and face centered cubic (fcc) regions.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 16
    ISSN: 1432-0630
    Schlagwort(e): PACS: 68.35 ; 81.10
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract.  C70 single crystals, free from solvent contamination, were grown via vapor phase transport technique. The (0001) face of the C70 crystal was imaged with Atomic Force Microscopy (AFM) under ambient atmosphere. Low-resolution images of a freshly prepared crystal revealed well-ordered faceted regions with multiple terraces extending over a region of several hundred square nanometers. The terraced structure in the images indicates that the crystals formed as a layer growth. In the high-resolution images, C70 molecules were resolved in a hexagonal close packed (hcp) structure with an average center-to-center distance of 10.5 ± 0.5 Å. After one month’s exposure to the ambient atmosphere, the molecules rearranged into a mixed structure consisting of hcp and face centered cubic (fcc) regions.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 17
    ISSN: 1432-0827
    Schlagwort(e): Bone resorption ; Osteoclast formation ; Resorption lacunae ; 24-epi-1α-hydroxyvitamin D2 ; 24-epi-1α,25-dihydroxyvitamin D2
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract Bone-resorbing activities of 24-epi-1α-hydroxyvitamin D2 [24-epi-1α(OH)D2], 24-epi-1α,25-dihydroxyvitamin D2 [24-epi-1,25(OH)2D2], and 1α,24S,25-trihydroxyvitamin D2 [1,24S,25(OH)3D2], which might be a metabolite of 24-epi-1,25(OH)2D2, were investigated. In an in vitro bone resorption test, the activity of 24-epi-1α(OH)D2 was similar to that of 1α-hydroxyvitamin D3 [1α(OH)D3] at 10-9 M-10-6 M. The activity of 24-epi-1,25(OH)2D2 was weaker than that of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] at 10-11 M-10-8 M. On the other hand, the activity of 1,24S,25(OH)3D2 was similar to that of 24-epi-1,25(OH)2D2 at 10-11 M-10-9 M. In the formation assay of osteoclast-like cells, the activity of 24-epi-1α(OH)D2 was weaker than that of 1α(OH)D3 at 10-7 M. The activity of 24-epi-1,25(OH)2D2 was almost similar to that of 1,25(OH)2D3 at 10-11 M-10-7 M. The activity of 1,24S,25(OH)3D2 was significantly weaker than that of 24-epi-1,25(OH)2D2 at 10-11 M-10-9 M. In the two experiments, the potencies of 24-epi-1,25(OH)2D2 were about 100 times higher than those of 24-epi-1α(OH)D2. In an in vivo/in vitro bone resorption test, the activity of 24-epi-1α(OH)D2 was almost similar to those of 1α(OH)D3 and 1,25(OH)2D3 and higher than those of 24-epi-1,25(OH)2D2 and 1,24S,25(OH)3D2. 24-epi-1α-(OH)D2 and 1α(OH)D3 were longer lasting than 24-epi-1,25(OH)2D2 and 1,25(OH)2D3 in this experiment. These results suggested that 24-epi-1α(OH)D2 as well as 1α(OH)D3 was converted into dihydroxy form in vivo.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 18
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Cytomegalvirus (CMV) establishes a latent infection in its host; however, the organ sites of viral latency and its mechanism still remain to be fully clarified. To elucidate this issue, a latent infection with murine (M) CMV was attempted to induce in mice and the organ sites of the latent viral genome were examined for more than one year by a polymerase chain reaction (PCR). As a result, latent MCMV DNA was detectable in both the lung and the spleen as late as 59 weeks after infection. The heart was also observed to be a target organ of latent MCMV DNA, though the amount of viral DNA was much less than that seen in the lung and spleen. In germfree (GF) mice, on the other hand, no such latent viral DNA was observed in the spleens, while it was seen, but to a significantly smaller degree, in the lungs and the hearts than in the same organs of specific pathogen-free (SPF) mice. The amount of infectious virions generated in the host appeared to be almost equal between the GF and SPF mice. The above findings therefore suggest that the spleen, lung and heart are target organs for MCMV latency and the indigenous bacterial flora, which are not colonizing in GF mice, play an important role in the establishment of such viral latency in SPF mice.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 19
    Digitale Medien
    Digitale Medien
    Springer
    Journal of materials science 30 (1995), S. 4801-4816 
    ISSN: 1573-4803
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract Transport properties of transition metal sulphides have been discussed in terms of chemical and self-diffusion coefficients. It has been shown that in the case of highly non-stoichiometric sulphides (Co1−yS) the chemical diffusion coefficient may easily be obtained from thermogravimetric measurements of re-equilibration kinetics. If the non-stoichiometry and thereby defect concentration is low (Mn1−yS), the re-equilibration kinetics is difficult or impossible to follow thermogravimetrically, and the electrical conductivity method can be applied. If the non-stoichiometry of a given metal sulphide is known as a function of temperature and sulphur activity, chemical diffusion data may successfully be utilized for calculation of parabolic rate constants of metal sulphidation and to obtain better insight into the growth mechanism of the sulphide scale. Using this procedure it has been shown that the sulphide scales on cobalt and manganese grow by the outward volume diffusion of cations. The chemical diffusion coefficient may also be used in the calculation of the self-diffusion coefficient of cations (or anions) if the non-stoichiometry data of a given sulphide are available. It has been shown that the self-diffusion coefficients of manganese in Mn1−yS obtained in such a way are in full agreement with those determined experimentally.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 20
    ISSN: 1435-1536
    Schlagwort(e): Ultrafine silica ; surface grafting ; molecular weight ; radical polymerization ; chain transfer agent
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Notizen: Abstract The effect of polymerization conditions on the molecular weight of polystyrene grafted onto silica obtained from the radical graft polymerization initiated by azo and peroxyester groups introduced onto the surface was investigated. The molecular weight of polystyrene grafted onto silica obtained from the radical graft polymerization initiated by surface azo and peroxyester groups decreased with decreasing monomer concentration and polymerization temperature. The molecular weight of polystyrene was found to be controlled to some extent by the addition of a chain transfer agent. The molecular weight of grafted chain on silica surface obtained from the graft polymerization initiated by surface radicals formed by photodecomposition of azo groups was considerably smaller than that by thermal decomposition. The number of grafted polystyrene in photopolymeriztion, however, was much larger than that in thermal polymerization. These results are explained by the blocking of surface radicals formed on the silica surface by previously grafted polymer chain: when the decomposition of surface azo and peroxyester groups proceed instantaneously at the initial stage of the polymerization, the number of grafted polymer chains increased.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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