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  • 11
    Electronic Resource
    Electronic Resource
    A gene for autosomal dominant juvenile amyotrophic lateral sclerosis (ALS4 ) localizes to a 500-kb interval on chromosome 9q34 (2000)
    Springer
    Neurogenetics 3 (2000), S. 1-6 
    Details
    ISSN: 1364-6753
    Keywords: Key words Amyotrophic lateral sclerosis ; ALS4 locus ; Fine mapping of ALS4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT Amyotrophic lateral sclerosis (ALS) denotes a heterogeneous group of neurodegenerative disorders affecting upper and lower motor neurons. ALS4 is a juvenile-onset, autosomal dominant form of ALS that is characterized by slow progression, distal limb weakness and amyotrophy, and pyramidal signs associated with severe loss of motor neurons in the brain and spinal cord. The ALS4 locus was recently mapped by linkage analysis to a large genetic interval on chromosome 9q34. By undertaking extensive genetic linkage analysis, we have significantly refined the ALS4 locus to a critical interval of less than 3 cM, flanked by D9S149 and D9S1198. Previous physical mapping in this region has indicated that this critical interval spans approximately 500 kb. Seventeen putative transcripts have been localized within this interval including 7 characterized genes, 2 partially characterized genes, and 8 "anonymous" expressed sequence tags . These are therefore positional candidate genes for the ALS4 locus. We have also undertaken mutation analysis and genetic mapping to investigate and exclude candidate genes, including RING3L/ORFX and RALGDS , from a pathogenic role in ALS4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/
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  • 12
    Electronic Resource
    Electronic Resource
    Nematode numbers, biomass and respiratory metabolism in a beech woodland—Wytham Woods, Oxford (1977)
    Springer
    Oecologia 27 (1977), S. 141-155 
    Details
    ISSN: 1432-1939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The mean annual population density of nematodes in the litter and upper 6 cm of soil was found to be 368,000 m-2. Mean individual live weight biomass approximated 0.2 μg and mean biomass was calculated to be 74.6 mg live weight m-2. No evidence of seasonal vertical migration between the litter, 0–3 cm and 3–6 cm strata was found and on average these strata contained 21.9, 46.2 and 31.9% respectively of the total number of nematodes recovered. The equivalent biomass values were 26.14, 56.57, and 17.29%. Total numbers revealed a general picture of low densities in spring and high ones in early winter, whereas biomass m-2 was low in late summer — autumn and high in winter. The annual oxygen consumption of the extracted nematodes was calculated to approximate 0.211 m-2 (≈4.0 kJ m-2) but when corrected for the effect of individual biomass (weight specific oxygen uptake) was equivalent to an energy expenditure ≈6.0 kJ m-2 which in its turn, because of the efficiencies of extraction, probably accounts for only 87% of the total energy expenditure by the nematode fauna. The nematodes were estimated to be responsible for a minimum of 0.11% to a maximum of 0.13% of the total “soil” respiration. A production/biomass ratio of 5.16 was estimated as was a net population production efficiency of 36.63%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345819
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  • 13
    Electronic Resource
    Electronic Resource
    Nichtinvasive intermittierende Selbstbeatmung (ISB) als Palliativmaßnahme bei amyotropher Lateralsklerose (1998)
    Springer
    Der Nervenarzt 69 (1998), S. 1074-1082 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Amyotrophe Lateralsklerose ; Nichtinvasive Beatmung ; Chronische Hypoventilation ; Palliativtherapie ; Key words Amyotrophic lateral sclerosis ; Home mechanical ventilation ; Chronic hypoventilation ; Palliative therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Almost all patients with amyotrophic lateral sclerosis (ALS) experience symptoms of nocturnal hypoventilation during the course of the illness. These symptoms can develop years before death and may severely affect quality of life. Non-invasive intermittent home mechanical ventilation (HMV) via mask is a possible palliative measure for these symptoms, which is not often used in Germany. We report on our experience with HMV in 24 patients with ALS. Our data show a good palliative effect in 17 of 24 treated patients. Severe complications did not occur. The mean ventilation time at present is 14 months. Available options and their consequences need to be discussed in detail with patients and relatives before HMV is initiated.
    Notes: Zusammenfassung Fast alle Patienten mit amyotropher Lateralsklerose (ALS) leiden im Verlauf der Erkrankung an Symptomen der chronischen Hypoventilation. Diese Symptome können Jahre vor dem Tod auftreten und die Lebensqualität erheblich beeinträchtigen. Eine Möglichkeit zur Linderung dieser Beschwerden stellt die nichtinvasive, intermittierende Selbstbeatmung über Maske (ISB) dar. Allerdings findet diese Maßnahme in Deutschland noch wenig Anwendung. Wir berichten über erste Erfahrungen mit der ISB bei 24 Patienten mit ALS. Unsere Daten zeigen eine gute palliative Wirksamkeit der ISB bei 17 von 24 behandelten Patienten. Schwere Komplikationen wurden nicht beobachtet. Die mittlere Beatmungsdauer beträgt derzeit 14 Monate. Voraussetzung für die Einleitung einer ISB ist eine frühzeitige und ausführliche Diskussion möglicher Optionen und deren Konsequenzen mit Patienten und Angehörigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050385
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  • 14
    Electronic Resource
    Electronic Resource
    Heuristics for the FMS-loading and part-type-selection problems (1993)
    Springer
    International journal of flexible manufacturing systems 5 (1993), S. 287-300 
    Details
    ISSN: 1572-9370
    Keywords: flexible manufacturing systems ; loading ; part type selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In this article, we study the FMS-loading and part-type-selection problems, in which each part is processed by a series of operations. Two heuristic methods are presented for the objectives of balancing workloads and meeting due dates. These heuristics perform a specific evaluation of the objective function at each iteration. The goal of Heuristic#1 is to achieve workload balance. The additional goal of Heuristic#2 is to reduce the number of late part types. The loading and part-type selection must satisfy a tooling constraint. Computational results are encouraging and indicate significant improvement over the existing methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01325032
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  • 15
    Electronic Resource
    Electronic Resource
    Characterisation of acrylate latices by potentiometry and spectrophotometry (1985)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 10 (1985), S. 297-303 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In the characterisation of latices conductometry is the technique most commonly used. In this paper it is shown that a thorough characterisation of latices is possible based mainly on potentiometric titrations in aqueous and non-aqueous media and on spectrophotometry. Results obtained with these techniques in the study of acrylate latices prepared with nonylphenolpolyethyleneoxidesulphate as the emulsifier are presented. It is shown that this type of emulsifier is subjected to considerable hydrolysis during the emulsion polymerisation process.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1985.020101985121
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  • 16
    Electronic Resource
    Electronic Resource
    Vergleichende Untersuchungen nach verschiedenen Methoden zur Bestimmung der „Tonsubstanz” in Kaolinen, Tonen und tonerdereichen Böden (1938)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 114 (1938), S. 456-456 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400105
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