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  • 11
    Electronic Resource
    Electronic Resource
    L(+)2-TROPINONE (1958)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 80 (1958), S. 6147-6147 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01555a062
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  • 12
    Electronic Resource
    Electronic Resource
    Antagonism of the IL-6 cytokine subfamily — a potential strategy for more effective therapy in rheumatoid arthritis (1998)
    Springer
    Inflammation research 47 (1998), S. 1-7 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Cartilage — Joint — Leukocyte — Proteoglycan — Receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Pro-inflammatory cytokines, some of which have the capacity to modulate cartilage and bone metabolism, are important mediators of the frequently sustained and destructive inflammation that characterises rheumatoid arthritis (RA). Tumour necrosis factor alpha (TNFα) and interleukin-1 (IL-1) have been studied extensively in this regard. That these proteins are important is no longer in doubt following the demonstration that the IL-1 receptor antagonist and neutralising antibodies directed against TNFα are clinically effective. Recent studies suggest that interleukin-6 (IL-6) and other members of the IL-6 cytokine subfamily are also potentially important cytokines in the pathogenesis of RA. The recognition of shared molecular subunits in the receptors for these cytokines raises the possibility that components of these receptors or their derivatives, either alone or in combination, may be useful for antagonising members of the IL-6 cytokine subfamily. Effective antagonism could be therapeutically beneficial in respect to attenuating inflammation and protecting critically important chondral and skeletal tissue. In this review the rationale and possible strategies for such antagonism are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050235
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  • 13
    Electronic Resource
    Electronic Resource
    Low-dose theophylline increases urine output in diuretic-dependent critically ill children (1998)
    Springer
    Intensive care medicine 24 (1998), S. 1099-1105 
    Details
    ISSN: 1432-1238
    Keywords: Key words Adenosine ; cAMP ; Dopamine ; Diuretic ; Theophylline ; Phosphodiesterase inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Determine the effect of low-dose theophylline on urine output and the urinary adenosine: cAMP (cyclic adenosine monophosphate) excretion ratio (a measure of phosphodiesterase inhibition) in diuretic-dependent critically ill children. Design: Observational clinical case series and animal laboratory experiment. Setting: A university pediatric intensive care unit and a pharmacology research laboratory. Patients: 10 consecutive oliguric patients treated with theophylline for diuresis. Interventions: Urine output, fluid intake, diuretic dosages, and number of pressors (including dopamine) were monitored over the 24-h period prior to and the 24-h period immediately after theophylline was started. Hourly collections of urine were obtained at baseline and 1 and 3 h after theophylline was started and urinary excretion rates of adenosine and cAMP were measured and calculated. Measurements and results: Mean theophylline level in the children was 5.0 μg/ml. Urine output increased from 1.58 ± 0.46 to 3.75 ± 0.77 ml/kg per h (p = 0.008, paired t-test) after theophylline administration. There was no significant change in fluid intake, vasoactive agents, or dosages of other diuretics during the study periods. Intrarenal infusion of the IC50 concentration of isobutylmethylxanthine for phosphodiesterase activity resulted in a reduction of the adenosine: cAMP urinary excretion ratio in rats (p 〈 0.05). Low-dose theophylline had no effect on the adenosine: cAMP urinary excretion ratio in children. Concurrent therapy with dopamine was associated with an enhanced diuretic effect of theophylline (with dopamine, 1.30 ± 0.30 to 5.07 ± 0.77 ml/kg per h vs without dopamine, 1.77 ± 0.76 to 2.86 ± 1.08 ml/kg per h; p = 0.03, two-way ANOVA). There was no interaction between dopamine and low-dose theophylline on the urinary adenosine: cAMP excretion ratio (p = 0.56, two-way ANOVA). Conclusions: Theophylline increased urine output in diuretic-dependent critically ill children and the diuretic effect may have been potentiated by concurrent use of dopamine. Adenosine receptor antagonism may be a more likely mechanism for the diuretic effect of theophylline than phosphodiesterase inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050723
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  • 14
    Electronic Resource
    Electronic Resource
    Candida albicans ALS3 and insights into the nature of the ALS gene family (1998)
    Springer
    Current genetics 33 (1998), S. 451-459 
    Details
    ISSN: 1432-0983
    Keywords: Key wordsCandida albicans ; Gene family ; Hyphal-specific ; Differential gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The ALS1 (agglutinin-like sequence) gene of Candida albicans encodes a protein similar to alpha-agglutinin, a cell-surface adhesion glycoprotein of Saccharomyces cerevisiae (Hoyer et al. 1995). A central domain of a tandemly repeated 108-bp sequence is found in the ALS1 coding region. This tandem-repeat motif hybridizes to multiple C. albicans genomic DNA fragments, indicating the possibility of other ALS1-like genes in C. albicans (Hoyer et al. 1995). To determine if these fragments constitute a gene family, tandem-repeat-hybridizing genomic fragments were isolated from a fosmid library by PCR screening using primers based on the consensus tandem-repeat sequence of ALS1 (Hoyer et al. 1995). One group of fosmids, designated ALS3, encodes a gene with 81% identity to ALS1. The sequences of ALS1 and ALS3 are most conserved in the tandem-repeat domain and in the region 5′ of the tandem repeats. Northern-blot analysis using unique probes from the 3′ end of each gene demonstrated that ALS1 expression varies, depending on which C. albicans strain is examined, and that ALS3 is hyphal-specific. Both genes are found in a variety of C. albicans and C. stellatoidea strains examined. The predicted Als1p and Als3p exhibit features suggesting that both are cell-surface glycoproteins. Southern blots probed with conserved sequences from the region 5′ of the tandem repeats suggest that other ALS-like sequences are present in the C. albicans genome and that the ALS family may be larger than originally estimated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050359
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  • 15
    Electronic Resource
    Electronic Resource
    Magnetic diagnostics and feedback control on TFTR (invited) (1985)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 56 (1985), S. 941-946 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The various operating modes of TFTR require the use of a sophisticated system of magnetic diagnostics integrated with a feedback control system. This system has successfully controlled the plasma current and position over a range of major and minor radii, during strong compression, and will soon be used during intense neutral beam heating. Current and position values are held constant to within 2 kA and 1 cm. A wide variety of preoperational field measurements were required to determine proper compensation for dynamic stray fields due to eddy currents. Data from plasma profile diagnostics, such as bolometer arrays, Thomson scattering, soft x-ray diode array, and the scanning radiometer, have been compared to the absolute position deduced from magnetics. In addition to control functions, magnetic diagnostics on TFTR provide data on plasma current asymmetry, βθ, MHD fluctuations, loop voltage, and flux consumption. This paper will discuss the mechanical and electronic design constraints, as well as the analytic and calibration techniques required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1138056
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  • 16
    Electronic Resource
    Electronic Resource
    Bioavailability of Eicosapentaenoic and Docosahexaenoic n-3 Polyunsaturated Fatty Acids in Salmon Patties Compared with Capsules (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 68 (2003), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This sequential treatment trial compared the bioavailability of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from salmon patties fortified with fish oil (DHA:EPA ratio = 1.8, total DHA + EPA about 2.2 g), unfortified salmon patties (DHA:EPA ratio = 1.9, total DHA + EPA about 1.1 g), and fish oil capsules (DHA:EPA ratio = 1.6, total DHA + EPA = 500 mg) in healthy older adults. Fortified salmon patties produced a significantly higher mean incremental area under the curve (AUCfasting-9 h) than unfortified patties for plasma EPA (37.6 in contrast to 12.9 μg·h/mL, p= 0.017), for plasma DHA (103.7 in contrast to 40.8 μg·h/mL, p= 0.035) and for plasma EPA + DHA (141.2 in contrast to 53.7 μg·h/mL, p= 0.031). Plasma EPA and DHA responses were larger with the fortified than the unfortified patties, indicating that fish oil incorporated into the salmon patties was bioavailable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2003.tb08238.x
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  • 17
    Electronic Resource
    Electronic Resource
    Use of a Neonatal Murine Retrovirus Model To Evaluate the Long-Term Efficacy and Toxicity of Antiviral Agents (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 616 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb17844.x
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  • 18
    Electronic Resource
    Electronic Resource
    Pulse-shortening in Electron Linear Accelerators and E 11 Type Modes (1963)
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 277-278 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In this laboratory we have made detailed theoretical and experimental investigations. of EH type fields in circular, iris-loaded wave-guides, specifically to utilize the deflecting forces for the spatial separation of high-energy particles of different rest masses. The results suggest that, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/198277a0
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  • 19
    Electronic Resource
    Electronic Resource
    Physical mapping studies on the human X chromosome in the region Xq27-Xqter
    Amsterdam : Elsevier
    Genomics 1 (1987), S. 297-306 
    Details
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0888-7543(87)90028-0
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  • 20
    Electronic Resource
    Electronic Resource
    Polyquarternary amines prevent peptide loss from sequenators
    Amsterdam : Elsevier
    Analytical Biochemistry 84 (1978), S. 622-627 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(78)90086-6
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