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  • 11
    Electronic Resource
    Electronic Resource
    The genetic effects of a range of anti-cancer drugs in the somatic mutation and recombination test in Drosophila
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 252 (1991), S. 193 
    Details
    ISSN: 0165-1161
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1161(91)90071-F
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  • 12
    Electronic Resource
    Electronic Resource
    The Drosophila wing test: A comparison of the sensitivity of different strains
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 203 (1988), S. 117-123 
    Details
    ISSN: 0165-1161
    Keywords: Adriamycin ; Cytosine arabinoside ; ENU ; MMS ; Methotrexate ; Strain sensitivity, wing test ; Wing test, Drosophila
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1161(88)90026-X
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  • 13
    Electronic Resource
    Electronic Resource
    The genetic effects of the anti-cancer drug methotrexate in somatic and germline cells of Drosophila
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 234 (1990), S. 375 
    Details
    ISSN: 0165-1161
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1161(90)90063-T
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  • 14
    Electronic Resource
    Electronic Resource
    Colorimetric Determination of Iron with Salicylaldoxime (1940)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 12 (1940), S. 448-450 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50148a003
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  • 15
    Electronic Resource
    Electronic Resource
    Ultraviolet reflectivity in three species of Lake Malaŵi rock-dwelling cichlids (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 65 (2004), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The body colouration extending into ultraviolet wavelengths in three species of Lake Malaŵi rock-dwelling cichlids, Metriaclima zebra, Metriaclima benetos and Metriaclima barlowi was quantified. All three species were ultraviolet reflective with interspecific differences in reflectivity. In addition, individuals were able to behaviourally mediate their reflectivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2004.00483.x
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  • 16
    Electronic Resource
    Electronic Resource
    Finite element modeling of powder aligning and multipole magnetizing systems for anisotropic bonded permanent magnets : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 6342-6344 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The manufacture of anisotropic bonded permanent magnets involves the application of an aligning field during the moulding of the magnet, and in most cases, particularly those involving anisotropic NdFeB powder, the subsequent application of a considerably larger magnitude magnetizing field, which in turn is usually produced by a capacitor discharge magnetizer and a geometry specific fixture. A finite element based method for modeling both of the production stages is presented, and the method is validated by a case study, which includes extensive material characterization on a four-pole anisotropic NdFeB cylinder. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361994
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  • 17
    Electronic Resource
    Electronic Resource
    Neuropeptide-Y Stimulates Pituitary-Adrenal Activity in Fetal and Adult Sheep (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neuroendocrinology 6 (1994), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) are the primary neuropeptides regulating the secretion of ACTH from the anterior pituitary gland during fetal and adult life. However, a number of other neuropeptides including neuropeptide-Y (NPY) appear to modulate the activity of this system. The potential role of NPY in the regulation of pituitary-adrenal function was examined in fetal and adult sheep. Administration of NPY (6.5 μg) as a bolus injection into the third cerebral ventricle of adult ewes elicited a significant (P〈0.05) increase in plasma concentrations of ACTH. In fetal sheep at day 125 gestation (term = 145 days) a five-fold higher dose (30 μg) of NPY injected into the lateral cerebral ventricles also caused a significant increase in plasma concentrations of ACTH. The potential of NPY to influence ACTH secretion directly from the pituitary gland was investigated using primary cultures of fetal (day 130 gestation) and adult pituitary cells. CRF (10−10–10−7 M) caused a significant (P〈0.01) dose-related increase in ACTH secretion from both fetal and adult pituitary cells. Furthermore, the secretion of ACTH from adult cells was significantly greater (P〈0.05) than that from fetal cells. NPY (10−10–10−7 M) had no effect on basal or CRF-stimulated ACTH secretion from fetal or adult pituitary cells. Pre-incubation of pituitary cells with cortisol (10−9 and 10−7 M) for three days significantly inhibited CRF-stimulated ACTH secretion but had no effect on basal ACTH release. The simultaneous addition of NPY did not alter the ability of cortisol to inhibit CRF-stimulated ACTH secretion.These data show that exogenous administraiton of NPY stimulates pituitary-adrenal activity in fetal and adult sheep. The lack of any direct pituitary effects of NPY suggests that this neuropeptide acts centrally within the brain to exert its effects on the pituitary-adrenal axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2826.1994.tb00567.x
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  • 18
    Electronic Resource
    Electronic Resource
    N-Methyl-DL-Aspartate Receptor Antagonism by D-2-Amino-5-Phosphonovaleric Acid Delays Onset of Puberty in the Female Rat (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neuroendocrinology 2 (1990), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the possible role of N-methyl-DL-aspartate (NMDA) receptor activation in the initiation of puberty, we examined the effects of the selective competitive antagonist 2-amino-5-phosphonovaleric acid (AP5) on the timing of vaginal opening. Paired and weight-matched litter mates of immature female rats were implanted with osmotic minipumps for the intracerebroventricular infusion of DL- or D-AP5 or artificial cerebrospinal fluid from 27 to 30 days of age for 14 days. Each animal was weighed and examined daily for vaginal opening as the indicator of first oestrous. Infusion of 20 or 40 mM DL-AP5 beginning on Day 30 failed to delay vaginal opening. Administration 50mM of the single enantiomer D-AP5 beginning on Day 27 significantly delayed the age of vaginal opening to 40.6±1.1 (mean ± SEM) days compared to the cerebrospinal fluid-infused controls (36.5 ± 0.6 days). Blockade of NMDA receptors in the D-AP5-treated animals was confirmed on Day 32 by the suppression of luteinizing hormone response to intravenous NMDA (20 mg/kg) while the response to exogenous luteinizing hormone-releasing hormone (50 ng/kg) remained intact. AP5-treated animals had a slower rate of growth (3.1 ± 0.2 g/day) compared to controls (4.2 ± 0.2 g/day). However, a similar degree of growth retardation produced by a 75% restricted diet in untreated juvenile animals did not delay vaginal opening. This suggests that the slower growth rate in the D-AP5-treated animals could not account for the delayed onset of puberty. In conclusion, these data suggest that blockade of central NMDA receptors inhibits excitatory mechanisms which may be important in the control of pubertal onset in the female rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2826.1990.tb00457.x
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  • 19
    Electronic Resource
    Electronic Resource
    Adrenocorticotrophin and Luteinizing Hormone Responses to N-Methyl-D-Aspartate During Fetal Development in Sheep (1996)
    Oxford : Blackwell Science Ltd.
    Journal of neuroendocrinology 8 (1996), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The hypothalamic mechanisms which underlie the development of the fetal neuroendocrine system are unclear. However, in adult animals neuroactive amino-acids, particularly those acting at the N-methyl-D-aspartate (NMDA) receptor, have been shown to be important transmitters involved in the neuroendocrine regulation of the anterior pituitary gland. In this study we have investigated the potential role of NMDA in the neuroendocrine regulation of fetal pituitary function, by examining the ontogeny of LH and ACTH responses to NMDA during fetal development in sheep. Catheterized fetal sheep were injected with 3 intravenous doses of NMDA (1, 2 and 4 mg/kg; estimated fetal body weight) and saline vehicle on consecutive days between days 110–115, 120–125 and 135–140 gestation (term=145 days). At each gestational age fetuses also received a pituitary challenge test consisting of CRF (0.4 μg/kg), AVP (80 ng/kg) and GnRH (125 ng/kg). NMDA caused a significant dose-related increase in ACTH at day 120–125 (P〈0.02) and day 135–140 gestation (P〈0.001). NMDA had no effect on ACTH secretion at day 110–115. The ACTH response to the highest does of NMDA (4 mg/kg) increased with advancing gestational age, in contrast to the ACTH response to CRF+AVP which was the same at all ages. NMDA caused a significant increase in LH secretion at all gestational ages with the greatest response observed at the latest gestational age studied (day 135–140). A similar increase in LH response to the GnRH challenge was observed late in gestation. Pretreatment of fetuses with the competitive NMDA antagonist CGP37849 (1 mg/kg) abolished the LH and ACTH responses to an intravenous injection of NMDA (4 mg/kg) given 5 min later. These data show that activation of NMDA receptors during fetal development elicits the secretion of ACTH and LH and demonstrate that NMDA receptors are functionally coupled to the neuroendocrine pathways regulating these two hormones during fetal life. The dramatic increase in ACTH repsonse to NMDA during the final days before birth occurs at a time of high adrenocortical activity and suggests an important functional role for these receptors at this time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2826.1996.04639.x
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  • 20
    Electronic Resource
    Electronic Resource
    Separation and determination of copper and nickel bysalicylaldoxime (1939)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 11 (1939), S. 251-253 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50133a007
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