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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 23 (1982), S. 397-401 
    ISSN: 1432-1041
    Keywords: hypertension ; prazosin ; alpha-adrenoceptors ; alpha-blocking drugs ; UK-33,274
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eleven patients with uncomplicated essential hypertension received increasing single daily doses of UK-33,274, a new alpha-1 adrenoceptor antagonist, and prazosin for 4 days, in a open cross-over study. Doses were increased until a satifactory blood pressure response was obtained. Average doses reached were 4.5 mg for UK-33,274 and 2.4 mg for prazosin. The maximum effect of the two drugs on standing blood pressure was similar, but prazosin was more effective in the supine position. Both drugs had a greater effect on standing than on supine blood pressure. UK-33,274 caused a consistent increase in heart rate while prazosin did not. Whereas there was no clear difference between the two compounds in the duration of the reduction in blood pressure the onset of action was more gradual for UK-33,274. The incidence of side-effects was similar for both drugs. The data suggest that UK-33,274 is less effective than prazosin in reducing blood pressure.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 166 (1978), S. 157-163 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunoelectroosmophoresis, complement fixation, immunofluorescence on inoculated cell cultures, electron microscopy, and an enzyme-linked immunosorbent assay were compared for the detection of rotavirus in faecal samples from calves. Rotavirus particles could be detected in 39 out of 98 faecal samples by electron microscopy. Immunofluorescence, complement fixation, and immunoelectroosmophoresis detected rotavirus antigens in 39, 42, and 30 samples, respectively. The enzyme-linked immunosorbent assay demonstrated rotavirus antigens in 49 faecal samples. The assay is not only sensitive but also simple to perform and suitable for large-scale testing.
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Tropical animal health and production 5 (1973), S. 57-64 
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les gains de poids de taureaux zébus de races Peulh Blanc, pur et demisang Frison, sont comparés dans 14 expériences. Dans toutes les expériences, l'alimentation est distribuéead libitum. Dans 7 essais, l'aliment est distribué sur un espace restreint, soit dans un feed lot, soit sur une surface relativement grande d'un terrain limité. Dans les 7 autres, les animaux sont placés dans un pâturage naturel, non amélioré (savane arbustive). Des rations de différentes qualités, dans le premier type d'expérience, produisent chez les Peulhs Blancs, des gains de poids variant de 191 à 873 g./jour. Au pâturage, suivant la qualité de ce dernier, les gains varient de 141 à 577 g./jour. Sur pâturage, les demi-sang n'ont pas de gains supérieurs à ceux des Peulhs Blancs. Sur surfaces limitées, les demi-sang ont des gains plus rapides que les Peulhs Blancs mais de façon significative uniquement dans les experiences oú la qualité de la ration permet un gain quotidien supérieur à 450 g. chez les zébus Peulhs. En conclusion, les demi-sang ne peuvent être recommandés qu'aux fermiers qui le désirent et qui sont capables de fournirad libitum, une ration de haute qualité, à condition que la prèhension de l'aliment ne soit pas un facteur limitant de la consommation. L'importance relative du remplacement du bétail indigène par des métis comme moyen d'améliorer la productivité de l'industrie de la viande dans le Nord Nigeria, est discutée.
    Abstract: Sumario Las ganancias de peso de toros puro Blanco Fulani y de 1/2 Friesian 1/2 Fulani fueron comparadas en 14 experimentos. En todos los experimentos el alimento se ofrecióad libitum. En siete experimentos el alimento fue ofrecido en manejo confinado, ya sea en comederos ó en relativamente grandes cantidades en un area limitada de terreno. En los otros siete experimentos se permitió que el ganado pastease en campos con pasto nativo no mejorado (Savanna con arbustos). Raciones differentes en calidad bajo manejo confinado estimularon la ganancia de peso de los toros Blanco Fulani con una variacion de −191 a +873 g por dia. El pastoreo de diferente calidad estimulo ganancias de peso en los Fulani Blancos con una variacion de −141 a +577 g por dia. En el pastoreo, las razas cruzadas no ganaron peso tan ràpido como los Blanco Fulani. Bajo manejo confinado, los cruces ganaron peso mas rápido que los Blanco Fulani pero solo significativamente en aquellos experimentos en los cuales la calidad de la ración permitia una ganancia diaria de mas de 450 g en los Blanco Fulani. Nosotros concluimos que los cruces solo pueden ser recomendados a ganaderos que quieran y puedan alimentar una ración de alta calidadad libitum bajo condiciones en las cuales la prehensión del alimento no sea un factor limitante en el consumo del mismo. La importancia relativa de reemplazar al ganado nativo con cruces como una medida hacia el mejoramiento de la productividad de la industria de la carne en el norte de Nigeria es discutida.
    Notes: Summary Weight gain of purebred White Fulani and1/2-Friesian1/2-White Fulani crossbred bulls were compared in 14 experiments. In all experiments food was offeredad libitum. In seven experiments food was offered on confined management, either in feedlot or in relatively large amounts on a limited area of land. In the other seven experiments the cattle were allowed to graze native, unimproved pasture (shrub savanna). Different quality rations on confined management supported weight gains of the White Fulani bulls varying from−191 to+873 g per day. Different quality range supported weight gains of White Fulanis varying from−141 to+577 g per day. On the range, crossbreds did not gain weight faster than the White Fulanis. On confined management, crossbreds gained weight faster than the White Fulanis but only significantly so on those experiments where the quality of the ration supported a daily gain of more than450 g in the White Fulanis. We conclude that crossbreds can only be recommended to farmers who are willing and capable of feeding a high quality rationad libitum, under conditions where prehension of the food is not a limiting factor for feed intake. The relative importance of replacing native cattle with crossbreds as a step towards improvement of the productivity of the beef industry in northern Nigeria is discussed.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Cardiovascular drugs and therapy 6 (1992), S. 565-569 
    ISSN: 1573-7241
    Keywords: hypertension ; elderly ; isolated systolic hypertension ; antihypertensive therapy ; cardiovascular mortality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent outcome trials in patients above age 60 with systolo-diastolic hypertension are reviewed. The metaanalysis suggests that antihypertensive drug therapy can decrease cardiovascular and coronary mortality in selected patients. Based on these studies it is suggested that antihypertensive drug therapy is indicated in patients between age 60 and 75 when the diastolic pressure remains above 95 mmHg after repeated measurements. A target for systolic b.p. is not definitely established but a pressure of 150 mmHg may serve as a temporary proposal. Whether uncomplicated isolated systolic hypertension in symptomless patients should be treated is still under investigation.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Cardiovascular drugs and therapy 2 (1988), S. 275-279 
    ISSN: 1573-7241
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary When studying the epidemiology ofPseudomonas aeruginosa, determination of the similarity of isolates is crucial. In the present study the distinctive capacity of four phenotyping methods (antibiotic susceptibility patterns, serotyping, phage-typing and outer membrane protein [OMP] profile analysis) was determined and compared to pulsed-field gel electrophoresis (PFGE) of enzyme restricted chromosomal DNA. In all, 91 isolates ofP. aeruginosa were cultured from ten patients. Antibiotic susceptibility patterns were concordant for all isolates. Serotyping yielded five, phage-typing eight, OMP profile analysis nine and PFGE seven distinct types ofP. aeruginosa. Compared to PFGE, the distinctive capacities were 89% (81/91) for serotyping, 87% (79/91) for phage-typing, and 90% (82/91) for OMP profile analysis. When serotyping results were different, PFGE types also were different (exclusiveness 100%). However, isolates with the same serotype may have various PFGE patterns. In contrast, isolates with similar PFGE patterns could have different phage-types or OMP types. For the study of isolates ofP. aeruginosa, serotyping provides a good initial selection to reduce the number of isolates that need to be genotyped.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 15 (1996), S. 437-445 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The incidence of tracheal colonization and its association with ventilator-associated pneumonia caused by methicillin-sensitiveStaphylococcus aureus (MSSA) was studied prospectively in 530 consecutively admitted mechanically ventilated patients in a general intensive care unit. Furthermore, the clinical spectrum, outcome, and microbiological results of 27 cases of staphylococcal ventilator-associated pneumonia (SVAP) were examined. Ventilator-associated pneumonia was diagnosed by protected specimen brush and/or bronchoalveolar lavage. On admission, 7% of the patients were colonized with MSSA in the trachea. Acquired tracheal colonization was demonstrated in 10% of the patients and occurred less frequently in patients with a hospital stay of 〉 48 h before ICU admission compared to patients admitted directly to the ICU (6% vs. 15%, p〈0.001). Moreover, colonization was acquired more frequently among trauma and neurological/neurosurgical patients (22%) as compared to surgical and medical patients (7%) (p〈0.0001). Twenty-one patients (4%) developed SVAP, the incidence being higher in patients colonized in the trachea with MSSA than in those not colonized (21 % vs. 1 %, p〈0.00001). Staphylococcal ventilator-associated pneumonia developed more often in trauma and neurological/neurosurgical patients as compared to surgical and medical patients (8% vs. 3%, p〈0.05). Moreover, patients with a hospital stay of 〈 48 h before admission to the ICU had a higher incidence of SVAP as compared to those with a longer hospital stay before ICU admission (7% vs. 2%, p〈0.01). Crude infection-related mortality was 26%. Preceding colonization with MSSA in the trachea appears to be an important risk factor for the development of SVAP, and patients with a short duration of hospitalization before intensive care unit admission have the highest incidence of ventilator-associated pneumonia caused by MSSA.
    Type of Medium: Electronic Resource
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