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  • 11
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1432-1440
    Keywords: Methotrexate ; Malignant neoplasm ; Carcinogenicity ; Chronic obstructive pulmonary disease ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 77-year-old man with chronic obstructive pulmonary disease was treated with low-dose methotrexate (7.5–15 mg per week). After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 203 (1973), S. 217-224 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei ausgedehnten Kettenzerstörungen stehen wir bei der Wiederherstellung einer guten Schallübertragung mitunter vor Problemen, die sich durch die Verwendung von allogenen Transplantaten and hier wiederum speziell mit dem zusammengesetzten Trommelfell-Hammertransplantat zum. Teil besser lösen lassen würden als mit den bisherigen Methoden. Dieser in das allogene Trommelfell eingelassene Hammer verfällt aber nach den bisherigen Erfahrungen der allmählichen Resorption, da ihm als wesentlicher Faktor für die knöcherne Integration eines allogenen Knochentransplantates der direkte Kontakt zum knöchernen Ersatzlager fehlt. Das allogene Trommelfelltransplantat wird in etwa 70% tauglich in das Empfängergewebe integriert, wobei jedoch mit stärkeren immunologisch bedingten Entzündungen und Reaktionen gerechnet werden muß als nach einer allogenen Gehörknöchelchen-Transplantation. Der Grunt hierfür ist in einem höheren Gehalt an Proteinen and einer vermehrten Mitübertragung von spendereigenen Plasmaproteinen zu sehen. Durch die Konservierung der Transplantate in Cialitlösung wird die Lösliehkeit der Proteine erniedrigt and die Freisetzung der Antigene verzögert, so daß these Transplantate mit einem besseren Resultat einheilen als die unkonservierten Transplantate.
    Notes: Summary Reconstructions of the middle-ear system after extensive destructions might best be handled by means of allogenic transplants, i. e., by a combined tympanic membrane/malleus transplant. Clinical experience indicates that the malleus is being resorbed; it lacks sufficient contact with the surrounding bones, a condition that is necessary for the integration of an osseous allogenic transplant. The tympanic membrane is being functionally integrated into the host tissues in about 700% of all cases. Nevertheless, the incidence of immunological reactions is considerably higher than that following a mere ossicular transplant. The reason for this lies in the higher protein content and the higher transference rate of donor serum protein. Cialit-stored transplants possess a low solubility of proteins, and, thus, the liberation of antigens is retarded. For these reasons, Cialit-treated transplants are better tolerated than untreated ones.
    Type of Medium: Electronic Resource
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