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  • 11
    Electronic Resource
    Electronic Resource
    Bubble characteristics and mass transfer in an airlift reactor with multiple net draft tubes (1998)
    Springer
    Bioprocess engineering 18 (1998), S. 323-328 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A pilot scale airlift reactor with multiple net draft tubes was developed. The reactor, 29 cm in diameter and 300 cm height, had four modules of double net draft tubes. Bubble size, bubble number, gas holdup, and volumetric mass transfer coefficient were measured under different superficial air velocities. The air velocity had little effect on bubble size but had significant influence on bubble number. A bubble column was also investigated for comparison. The airlift reactor had a higher gas holdup and volumetric mass transfer coefficient than those in the bubble column. The draft tubes in the airlift reactor substantially improved the reactor performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050450
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Effect of setpoint on L-lysine fermentation (1998)
    Springer
    Bioprocess engineering 19 (1998), S. 415-418 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract In control of a bioprocess, setpoint of fed-batch fermentation processes has a great influence on both the cost and the operating efficiency. Determination of a setpoint depends on the system and objective function. This work investigates two operating conditions for a fed-batch culture of L-lysine production. One is to maintain the reducing sugar concentration (RSC) on a constant setpoint, whereas the other has a piecewise variation of the RSC setpoint. Productivity, yield, and a cost function are employed to evaluate the performance of different setpoints on the fermentation process. Constant setpoint which is commonly used in fed-batch culture is not the best approach in L-lysine fermentation. Piecewise variation of setpoint shows that the better policy is to set the RSC at a higher concentration in the early cell growth stage then to decrease the RSC to a lower level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050541
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Modelling of L-lysine fed-batch culture based on combined neural network estimators (1995)
    Springer
    Bioprocess engineering 13 (1995), S. 323-329 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  Modelling of a bioprocess was developed by combining three neural network estimators (NNEs). The bioprocess was for fed-batch culture of L-lysine production. The NNEs were NNE1, NNE2, and NNE3. NNE1 was applied to estimate the consumed sugar concentration, L-lysine concentration, and cell optical density. NNE2 was utilized to determine the off-gas concentration of O2 and CO2 while NNE3 was employed to predict the agitation speed. These NNEs possessed their own distinct functions and could be used independently. Combination of the NNEs based on neural network gave an easy and significant way for modelling a bioprocess.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369565
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    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Oxygen transfer in an airlift reactor with multiple net draft tubes (1996)
    Springer
    Bioprocess engineering 15 (1996), S. 59-62 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  A pilot scale airlift reactor with multiple net draft tubes was developed to improve oxygen transfer in the reactor. The reactor was 0.29 m in diameter and 2 m height. A steady-state sulfite oxidation method was applied to determine an overall volumetric mass transfer coefficient. Oxygen transfer of the proposed airlift reactor can be 60–100% higher than that of bubble columns under the same operating conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372978
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    Paper (German National Licenses)
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  • 15
    Electronic Resource
    Electronic Resource
    An airlift reactor with double net draft tubes and its application in fermentation (1997)
    Springer
    Bioprocess engineering 17 (1997), S. 1-5 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract An airlift reactor with double net draft tubes was developed. A sparger was located between the two draft tubes. The draft tubes had a significant effect on breaking bubbles into smaller ones. The assessment of the reactor performance was based on gas holdup, mixing time, and volumetric mass transfer coefficient. The proposed reactor had higher gas holdup and volumetric mass transfer coefficient, and lower mixing time in comparison with those of the bubble column. Application of the proposed reactor to fermentation of Saccharomyces cerevisiae demonstrated that the cultivation time was significantly shortened.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050344
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    Paper (German National Licenses)
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  • 16
    Electronic Resource
    Electronic Resource
    Mass transfer and liquid mixing in an airlift reactor with a net draft tube (1995)
    Springer
    Bioprocess engineering 12 (1995), S. 221-225 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  Mass transfer and liquid mixing in an airlift reactor with a net draft tube were experimentally investigated. Four different column diameters were considered. The mass transfer was measured using the volumetric gas-liquid mass transfer coefficient which was determined by the dynamic method. The mass transfer coefficients in the airlift reactors with different column diameters were not always higher than those in the bubble columns. The liquid mixing was measured using mixing time which was determined by a pulse technique. Under the same superficial gas velocity, the mixing times of the airlift reactors with a net draft tube were always less than those of the bubble columns. List of symbols C mol ⋅ dm-3 bulk concentration of dissolved oxygen C o mol ⋅ dm-3 initial concentration of dissolved oxygen C e mol ⋅ dm-3 saturated concentration of dissolved oxygen C¯– dimensionless dissolved oxygen concentration D C cm diameter of column D N cm diameter of the nozzle hole D T cm diameter of the net draft tube H L cm static liquid height H T cm height of the net draft tube k L a hr-1 volumetric mass transfer coefficient L T cm length of the net draft tube t M sec mixing time of the liquid phase t o sec mixing time of the liquid phase in a bubble column V L dm3 volume of the liquid phase U g cm/s superficial air velocity
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369494
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    Paper (German National Licenses)
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  • 17
    Electronic Resource
    Electronic Resource
    Fed-batch culture for L-lysine production via on-line state estimation and control (1993)
    Springer
    Bioprocess and biosystems engineering 9 (1993), S. 135-139 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Computer application for fed-batch culture of Brevibacterium flavum for L-lysine production has been developed. The organisms are auxotrophic mutants for L-homoserine and are resistant to S-(2-aminoethyl)-L-cysteine. Adaptive control is applied for substrate addition. The sugar concentration is estimated using online respiratory measurement. During the period of fed-batch culture, the total sugar concentration is maintained at a given value. The cultivation strategy results in high productivity and high conversion yield.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389920
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    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Modelling of L-lysine fed-batch culture based on combined neural network estimators (1995)
    Springer
    Bioprocess and biosystems engineering 13 (1995), S. 323-329 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Modelling of a bioprocess was developed by combining three neural network estimators (NNEs). The bioprocess was for fed-batch culture of L-lysine production. The NNEs were NNE1, NNE2, and NNE3. NNE1 was applied to estimate the consumed sugar concentration, L-lysine concentration, and cell optical density. NNE2 was utilized to determine the off-gas concentration of O2 and CO2 while NNE3 was employed to predict the agitation speed. These NNEs possessed their own distinct functions and could be used independently. Combination of the NNEs based on neural network gave an easy and significant way for modelling a bioprocess.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369565
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    Oxygen transfer in an airlift reactor with multiple net draft tubes (1996)
    Springer
    Bioprocess and biosystems engineering 15 (1996), S. 59-62 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A pilot scale airlift reactor with multiple net draft tubes was developed to improve oxygen transfer in the reactor. The reactor was 0.29 m in diameter and 2 m height. A steadystate sulfite oxidation method was applied to determine an overall volumetric mass transfer coefficient. Oxygen transfer of the proposed airlift reactor can be 60–100% higher than that of bubble columns under the same operating conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372978
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 20
    Electronic Resource
    Electronic Resource
    Glutamic acid production in an airlift reactor with net draft tube (1992)
    Springer
    Bioprocess and biosystems engineering 8 (1992), S. 183-187 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Cultivation of Brevibacterium divaricatum for glutamic acid production in an airlift reactor with net draft tube was developed. Cell concentration gave an index for adding penicillin G. On-line estimation of total sugar concentration yielded an identified model which was used for determination of the substrate addition. Fermentation for glutamic acid production requires high oxygen concentration in the broth. The proposed reactor has the capability to provide sufficient oxygen for the fermentation. Since the reactor is suitable for fed-batch culture, the cultivation of B. divaricatum for glutamic acid production in the proposed reactor is successfully carried out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254235
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    Paper (German National Licenses)
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