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  • 21
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    Aberdeen, etc. : Periodicals Archive Online (PAO)
    Scottish historical review. 14 (1916/1917) 192 
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  • 22
    facet.materialart.
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    Aberdeen, etc. : Periodicals Archive Online (PAO)
    Scottish historical review. 14 (1916/1917) 192 
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  • 23
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] For these studies the ability of different compounds to activate or to antagonize the activation of transcription of nodABCIJ and nodFE was monitored by the use of gene fusions. Two Rhizobium test strains contained either the nodC-lacZ fusion plasmid pi J1477 or the nodF-lacZ fusion plasmid pi ...
    Type of Medium: Electronic Resource
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  • 24
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 36 (1989), S. 29-34 
    ISSN: 1432-1041
    Keywords: theophylline ; asthma ; clearance ; age ; adults ; elderly ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline. Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age. Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.
    Type of Medium: Electronic Resource
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  • 25
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 102 (1989), S. 257-264 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract We present data on the phase relationships of mixtures between natural tonalite and peridotite compositions with excess H2O at 30 kbar, and on the composition of the piercing point where the peridotite-tonalite mixing line intersects the L(Ga,Opx) reaction boundary. These data, in conjunction with earlier analogous data along peridotite-granite and basalt-granite mixing lines, permit construction of a pseudoternary liquidus projection that is relevant to interaction of peridotite with slab-derived magmas. Knowledge of the liquidus phase and temperature for a range of compositions within this projection enables us to map primary crystallization fields for quartz, garnet, orthopyroxene, clinopyroxene, and olivine, and to estimate the distribution of isotherms across the projection. Using this projection, we explore the consequences of peridotite assimilation by mafic to intermediate (basalt to dacite) hydrous slab-derived melts. Progressive assimilation under isothermal conditions results in garnet precipitation as the melt composition traverses the garnet liquidus surface and then garnet+orthopyroxene crystallization once the melt reaches the L(Ga,Opx) field boundary. The melt is constrained to remain on this field boundary and further assimilation of peridotite simply results in continued precipitation of garnet+orthopyroxene until the melt is consumed. The product is a hybrid solid assemblage consisting of Ga+ Opx. It is noteworthy that this process drives the melt composition in a direction nearly perpendicular to the mixing line between peridotite and the initial melt. If assimilation occurs with increasing temperature (as might occur if a slab-derived magma rises into the hotter mantle wedge), intermediate magmas (e.g. andesites) will again precipitate garnet until they reach the L(Ga,Opx) reaction boundary at which point Ga re-dissolves and orthopyroxene precipitates as the melt composition moves up-temperature along this boundary. The product of this process is a hybrid solid assemblage with garnet subordinate to orthopyroxene. For more mafic initial compositions (e.g. basalts) originally plotting in the Cpx field, it appears possible to avoid field boundaries involving garnet and shift in composition more directly toward peridotite, if assimilation is accompanied by a sharp increase in temperature. Considering published REE evidence (arguing against garnet playing a significant role in the genesis of many subduction-related magmas) in light of our results, it appears unlikely that peridotite assimilation by intermediate magmas under conditions of constant or increasing temperature is an important process in subduction zones. However, if assimilation is accompanied by an increase in temperature, our data do permit the derivation of high-Mg basalts from less refractory precursors (e.g. high-Al basalts) by peridotite assimilation.
    Type of Medium: Electronic Resource
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  • 26
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 100 (1988), S. 35-46 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract We report the T-X(H2O) phase relations for the trondhjemitic Nûk gneiss which comprises the principal component of the second phase of Archean (3.0–2.8 by) igneous activity in the Godthåb region of southwestern Greenland. A pressure of 15 kbar was chosen to place constraints on possible protoliths for trondhjemitic melts at lower crustal depths. Under H2O-saturated conditions, a melting interval of ∼135° C separates the solidus at ∼610° C from the liquidus at 745° C. H2O-saturation at 15 kbar occurs at approximately 15.5 wt % H2O. The H2O-undersaturated liquidus extends along a curved path from ∼745° C at 15.5 wt % H2O to ∼1100° C at 2% H2O. Lower H2O contents were not investigated. At low H2O contents (〈6%) sodic plagioclase (Pl, An32) is the liquidus phase followed at lower but still near-liquidus temperatures by quartz (Qz) and then garnet (Ga). At 6% H2O, Ga replaces Pl on the liquidus and is joined at slightly lower temperatures by Pl and hornblende (Hb). The field for liquidus Ga extends to only ∼7.5% H2O where it is replaced by Hb which is the liquidus phase up to 13% H2O. At all higher H2O contents, epidote (Ep) is the first phase to crystallize, followed by biotite (Bi) at slightly lower temperatures. Following the standard inverse approach, the near-liquidus phase assemblages are interpreted as potential residues from which trondhjemitic melts could be extracted. At high melt H2O contents (〉7%), mafic residues consisting of some combination of Hb, Ga, Ep, and Bi are possible and could correspond to amphibolitic source rocks. At lower melt H2O contents (〈 5%), possible residues consist of Na-Pl+Qz±Ga and could correspond to an earlier generation of tonalitic-trondhjemitic rocks. However, such residues would not impart the highly fractionated REE patterns characteristic of Archean trondhjemites. If a first generation of tonalitic-trondhjemitic melts was generated by higher pressure partial fusion of eclogite and emplaced at 55 km depth, it would crystallize to an assemblage consisting almost entirely of Na-Pl+Qz with highly fractionated REE patterns. These rocks in turn could be partially melted to yield a second generation of trondhjemites which would inherit the highly fractionated REE patterns because neigher Pl nor Qz is capable of significantly fractionating HREE from LREE.
    Type of Medium: Electronic Resource
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  • 27
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 29 (1985), S. 177-179 
    ISSN: 1432-1041
    Keywords: theophylline clearance ; age ; adult age range ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty volunteers aged between 20 and 57 years were given 197 mg of theophylline (as lysine theophylline) by iv infusion over 5 minutes to test the hypothesis that within the adult age range theophylline clearance declines with age. Samples were assayed for theophylline using the EMIT assay and clearance was determined by standard methods. Clearance values were 0.73 ml/min/kg below age 38 years and 0.75 ml/min/kg at and above age 38 years. Multiple regression analysis using age as a continuous variable showed no relationship between age and clearance.
    Type of Medium: Electronic Resource
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  • 28
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 28 (1985), S. 253-255 
    ISSN: 1432-1041
    Keywords: disopyramide ; flecainide ; myocardial infarction ; drug plasma binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In the serum basic drugs are principally bound to alpha1-acid glycoprotein (AAG). Following acute myocardial infarction it has been shown that the levels of AAG rise. The serum levels of total protein, albumin, AAG and the protein binding of 2 antiarrhythmic drugs which are bases, disopyramide and flecainide, was measured in vitro with blood samples from eleven patients taken over the first 5 days following myocardial infarction. Mean AAG levels significantly increased from 1.04 g/l on Day 1 to 1.80 g/l on Day 5. The binding of disopyramide, which is highly bound, rose from 80% to 87%, representing a 35% decrease in free drug concentration. In contrast the binding of flecainide fell from 61% to 53%, a 20% increase in free drug concentration. These data suggest that although the binding of strongly bound drugs responds appropriately to increases in binding protein after acute myocardial infarction, poorly bound drugs are displaced from binding sites possibly by endogenous substances. Since the pharmacological effects of a drug are related to its free (unbound) concentration, the changes in the proportions of free to bound drug after myocardial infarction may have important clinical implications.
    Type of Medium: Electronic Resource
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  • 29
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 11 (1987), S. 277-282 
    ISSN: 1432-5195
    Keywords: Methyl methocrylate Heat of polymerisation ; Small bones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le but de ce travail est d'étudier les effets thermiques de la polymérisation sur les petits os longs. Les résultats montrent seulement, durant la prise du ciment, une élevation modérée de la température dans la cavité médullaire de ces os. L'élévation maximale (11° 7) est dans les limites de tolérance des cellules osseuses vivantes. Il a été démontré que les petites quantités de méthyl-métacrylate refroidissent plus rapidement, donc que diminuent davantage les effets nuisibles de la chaleur. Les examens histologiques ne montrent aucune altération due aux effets thermiques de la polymérisation du méthyl-métacrylate sur les petits os longs ni sur les tissus de recouvrement.
    Notes: Summary This study was designed to investigate the thermal effects of polymerization on small tubular bones. The results demonstrated only a slight increase in temperature during cement-curing in the medullary canals of these bones. The maximum rise (11.7° C) was within the levels of tolerance for living bone cells. It was demonstrated that the small volumes of methyl-methacrylate cool more rapidly, hence further decreasing the deleterious effects of heat. The histological studies showed no recognisable adverse reaction to the thermal effects of methyl-methacrylate polymerization on small tubular bones or on the overlying tissue.
    Type of Medium: Electronic Resource
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  • 30
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A strain of R. phaseoli cured of its symbiotic plasmid, pRP2JI, retained the ability to make exopolysaccharide (EPS). However, a region of pRP2JI, when cloned at an increased copy number in wide host-range vectors and transferred to this and other strains of Rhizobium, inhibited EPS synthesis. The gene responsible was termed psi (polysaccharide inhibition) and was located in a region of the symbiotic plasmid close to nodulation and nitrogen fixation genes. psi is important in the symbiosis since a wild-type strain containing psi cloned on a multicopy plasmid failed to form Phaseolus nodules, and mutant strains containing psi::Tn5 mutations failed to fix nitrogen in Phaseolus nodules. It is proposed that the function of psi may be to repress in the bacteriod the expression of genes such as those for EPS synthesis which are normally expressed in free-living culture.
    Type of Medium: Electronic Resource
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