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  • 1
    Digitale Medien
    Digitale Medien
    Fully automated solid phase synthesis of protected peptide hydrazides on recycling hydroxymethyl resin (1976)
    s.l. : American Chemical Society
    The @journal of organic chemistry 41 (1976), S. 3255-3258 
    Details
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jo00882a009
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  • 2
    Digitale Medien
    Digitale Medien
    A SENSITIVE FLUOROMETRIC METHOD FOR THE ESTIMATION OF 3,4-DIHYDROXYPHENYLETHYLENE GLYCOL SULPHATE IN BRAIN TISSUE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— A simple fluorometric method for the estimation of endogenous 3,4-dihydroxyphenylethylene glycol sulphate (DOPEG-SO4) in brain tissue is described. DOPEG-SO4 was extracted from brain tissue with 0.4 n-perchloric acid and purified by column chromatography on QAE-Sephadex A-25, Cl− form. The isolated DOPEG-SO4 was hydrolysed by incubation with a purified preparation of sulphatase from Helix pomatia. The free DOPEG thus formed was further purified on a column of aluminium oxide and determined fluorometrically after conversion to a fluorescent compound by condensation with ethylenediamine.The sensitivity of this method was about 15 ng per perchloric acid extract applied on the column (3 ml) and the reproducibility was excellent, with a variation coefficient of 1.6% (n = 5). The concentration of DOPEG-SO4 in whole brains of rats, determined by the present method, was 79.3 ± 4.7 ng/g (mean ± S.D., n = 10) in terms of free DOPEG. No appreciable DOPEG-SO, was detected in the brains of mice and guinea-pigs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10488.x
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  • 3
    Digitale Medien
    Digitale Medien
    Human gnathostomiasis (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 18 (1991), S. 0 
    Details
    ISSN: 1600-0560
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Two patients became infested with Gnathostoma nipponicum after eating raw loach-fish they had caught in a rice field in central Japan. A fragment of Gnathostoma was found in a biopsy from one of them. The sera of both patients reacted with Gnathostoma antigen using indirect immunofluorescence. Scanning electron microscopy was performed on blocks of the paraffin-embedded parasite sample and the viscera of a fish from the same rice field. The risk of eating raw freshwater fish is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0560.1991.tb00137.x
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  • 4
    Digitale Medien
    Digitale Medien
    THE ROLE OF PRIOR AUSTENITE GRAINS IN FATIGUE CRACK INITIATION AND PROPAGATION IN LOW CARBON MARTENSITE (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 2 (1979), S. 0 
    Details
    ISSN: 1460-2695
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Maschinenbau
    Notizen: Abstract— A study has been made of the role of Prior Austenite Grains (PAG) in fatigue crack initiation and propagation in low carbon martensite.The occurrence of ferrite precipitation along prior austenite grain boundaries during rapid cooling will lead to the formation of intergranular cracking. This intergranular cracking has a close relationship with the reduction of the endurance limit for fine grained low carbon martensite.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1460-2695.1979.tb01083.x
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  • 5
    Digitale Medien
    Digitale Medien
    Distribution, excretion and biotransformation of 14C-piromidic acid in goldfish Carassius aumtus (L.) (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 2 (1979), S. 0 
    Details
    ISSN: 1365-2761
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: Abstract. The pharmacokinetic and metabolic disposition of piromidic acid (PA) was studied in goldfish orally administered a single dose of 40 mg/kg of PA or 14C-PA with the following results. PA was rapidly absorbed from the alimentary tract and became widely distributed to give maximal organ and tissue levels mostly after 1 h post dosing. Organ and tissue levels of PA as measured by the radioactivity were 1.4–2.2 times as high as those obtained by the bioassay, though their distribution patterns were similar. PA was partly biotransformed to unconjugated antibacterial metabolites, i.e., α-OHPA and β-OHPA and partly to more hydrophilic glucuronides which were excreted into bile. Bioactive metabolites along with PA disappeared almost entirely from the fish within 48 h post dosing. The antibacterial activity of α-OHPA and β-OHPA against major pathogenic bacteria isolated from fish showed two to four-fold greater activity as compared with PA. This pharmacokinetic and metabolic disposition, together with the antibacterial activity of PA and its active metabolites, suggest a possible practical application of PA against bacterial fish diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2761.1979.tb00414.x
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  • 6
    Digitale Medien
    Digitale Medien
    The evaluation of piromidic acid as an antibiotic in fish: an in vitro and in vivo study (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 2 (1979), S. 0 
    Details
    ISSN: 1365-2761
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: Abstract. The activity of piromidic acid (PA, 8-ethyl-5, 8-dihydro-5-oxo-2-prior lidinopyrido [2,3–d] pyrimidine-6-carboxylic acid) against bacteria in fish was evaluated in vitro and in vivo. In vitro, PA was effective against a wide range of pathogenic bacteria stocked in this laboratory and freshly isolated from fish. PA was active against organisms showing multiple drug-resistance and showed no cross-resistance to chloramphenicol, tetracycline and sulfamonomethoxine. In vivo, orally administered PA was effective against experimental infections with Aeromonas hydrophila and Vibrio spp. in goldfish and eels. The efficacy of PA against these infections was equal to or higher than that of chloramphenicol, and higher than that of tetracycline. Distribution of PA in the Ash was investigated by bioassay and autoradiography. In the bioassay, orally administered PA was easily absorbed and distributed in the blood and tissues of major organs within 1 h after the administration. Peak levels were attained 2 to 4 h post dosing, and no residue was detected in the blood and tissues 48 h post dosing. The results obtained from the autoradiographic investigation in goldfish were similar to those from the bioassay. Therapeutic levels of PA were well tolerated by fish when administered with feed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2761.1979.tb00174.x
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  • 7
    Digitale Medien
    Digitale Medien
    Kieselsäure-Germaniumoxid-Adsorbentien. II. Die Reaktion von Germaniumtetrachlorid mit Kieselsäure (1977)
    Springer
    Colloid & polymer science 255 (1977), S. 811-812 
    Details
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01664485
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  • 8
    Digitale Medien
    Digitale Medien
    Developmental change of EEG in rat from 4th to 16th week (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 879-880 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The development of EEG in 8 male rats from 4 to 16 weeks age were studied chronically. Theta band had the highest power at 5–16 weeks. Especially after 11 weeks, theta band presented a signigicantly higher peak than that of 4-week-old. In contrast to this, delta band, which had the highest power at 4 weeks, was markedly decreased.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01955125
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  • 9
    Digitale Medien
    Digitale Medien
    7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide a new antihypertensive agent (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 55-57 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary 7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide (DU-717) is a new compound having sustained antihypertensive activity in a similar manner to that of hydrochlorothiazide. However, this compound shows neither diuretic nor hyperglycemic effect, being different from those of hydrochlorothiazide or diazoxide.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01936752
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  • 10
    Digitale Medien
    Digitale Medien
    New compositional and optical data for antimonian and bismuthian varieties of hemusite from Japan (1991)
    Springer
    Mineralogy and petrology 45 (1991), S. 11-17 
    Details
    ISSN: 1438-1168
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Neue chemische und optische Daten für antimon- und bismuthführende Hemusite auf epithermalen Au-Ag-Cu Lagerstätten in Japan werden vorgelegt. Die empirische Formel für die antimon-führende Varietät aus der Iriki-Mine ist: (Cu5.83Fe0.14Ag0.01)Σ5.98Mo1.03(Sn0.54Sb0.41Te0.03Bi0.02)Σ1.00 (S7.85Se0.15)Σ8.00, und die der Sb-Bi Varietät aus der Kawazu Mine ist: (Cu5.84Fe0.14Ag0.01)Σ5.99M01.03(Sn0.82Sb0.11Bi0.l0Te0.04)Σ1.07 (S7.80Se0.12)Σ7.92. Die theoretische Formel von Hemusit ist Cu+ 4Cu2+ 2Mo4+Sn4+S8, während die wahrscheinlichere Formel für den Hemusit von Iriki Cu+ 4Cu2+ 1.5Mo4+Sn4+ 0.5Sb5+ 0.5S8, mit Sb5+ an der Stelle von Sn4+, das(SbS4)3− Tetraeder bildet, wie zu erwarten ist, unter der Voraussetzung, da♭ das Metall zu Schwefelverhältnis 1 und die Struktur sphaleritähnlich ist. Bi3+ kann jedoch nicht in dieser Weise untergebracht werden, und das führt zu einem Mangel an (S + Se) für den Hemusit von Kawazu. Die Reflektions-Spektren beider Minerale werden mit denen des Wolfram-Equivalents von Hemusit (Kiddcreekit) verglichen. Die Beziehung zwischen Hemusitsensu stricto und diesen jetzt beschriebenen Varietäten wird auf der Basis einfacher und gekoppelter chemischer Substitution diskutiert. Auf dieser Basis werden Schlüsse auf die Valenz von Sb, Bi Mo und Cu in der Hemusit-Struktur gezogen.
    Notizen: Summary New compositional and optical data are reported for antimonian and antimonianbismuthian varieties of hemusite from epithermal Au-Ag-Cu deposits in Japan. The empirical formula for the antimonian variety, from the Iriki mine is: (Cu5.83Fe0.14Ag0.01)Σ5.98Mo1.03(Sn0.54Sb0.41Te0.03Bi0.02)Σ1.00(S7.85Se0.15)Σ8.00, and that of the Sb-Bi variety from the Kawazu mine is: (Cu5.84Fe0.14Ag0.01)Σ5.99Mo1.03(Sn0.82Sb0.11Bi0.l0Te0.04)Σ1.07(S7.80Se0.12)Σ7.92. The theoretical formula of hemusite is Cu+ 4Cu2+ 2MO4+Sn4+S8, whilst the most probable formula of the Iriki hemusite is Cu+ 4.5CU2+ 1.5Mo4+Sn4+ 0.5Sb5+ 0.5S8, with Sb5+ substituting for Sn4+ and forming (SbS4)3− tetrahedra as might be expected, given that the metal to sulphur ratio is 1, and given the sphalerite-like structure of the mineral. However Bi3+ cannot be so accommodated, resulting in a deficiency in (S + Se) for Kawazu hemusite. Reflectance spectra for both are compared with those of the tungsten analogue (compositional) of hemusite, kiddcreekite. The relationship between hemusitesensu stricto and these newly reported varieties is discussed in terms of simple and coupled chemical substitutions, and inferences are drawn on the valency of Sb, Bi, Mo and Cu in the hemusite structure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01164499
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