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  • 1
    Digitale Medien
    Digitale Medien
    Cutaneous inflammatory pseudotumour (plasma cell granuloma) (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04253.x
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  • 2
    Digitale Medien
    Digitale Medien
    Expression of mRNA for androgen receptor, 5α-reductase and 17β-hydroxysteroid dehydrogenase in human dermal papilla cells (1999)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 141 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In order to determine whether adrenal and gonadal weak androgens are utilized to form active androgens in human hair, we studied the expression of mRNA for androgen receptor (AR), 5α-reductase and 17β-hydroxysteroid dehydrogenase (17β-HSD) in cultured dermal papilla cells (DPCs) from various body sites. AR mRNA was expressed in beard (Be) and axillary hair (Ax) DPCs from both sexes, but only at a low level in DPCs from occipital scalp hair (OS). Type I 5α-reductase mRNA was expressed by all DPCs. Type II 5α-reductase mRNA was identified in beard DPCs, but was absent from OS and Ax DPCs. Type II 17β-HSD mRNA was strongly expressed in outer root sheath cells (ORSCs), while DPCs except for male Ax expressed no type II 17β-HSD mRNA. In contrast, type III 17β-HSD mRNA was strongly expressed in Be DPCs and Ax DPCs from both sexes; ORSCs showed a low level of expression. Expression of type III 17β-HSD mRNA was not regulated by androgen in DPCs. These results suggest that the sensitivity of hairs to androgen is partially controlled by the site-specific expression of AR, 5α-reductase and 17β-HSD in DPCs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.03156.x
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  • 3
    Digitale Medien
    Digitale Medien
    Compound heterozygous group A xeroderma pigmentosum patient with a novel mutation and an inherited reciprocal translocation (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The severity of neurological abnormalities in Japanese group A xeroderma pigmentosum (XP-A) patients correlates with the sites of non-sense mutation in the XP-A gene. We describe a patient who presented with a more severe photosensitivity and neurological abnormality than those in typical Japanese XP-A patients with a splicing mutation in intron 3. The patient was compound heterozygous for the splicing mutation in intron 3, which resulted in formation of a non-sense codon in exon 4, and a novel non-sense mutation at codon 208 in exon 5, a C to T transition creating a stop codon TAG. Although the combination of these mutations might have been thought to cause only mild neurological signs, the longer truncated XP-A proteins than those of typical XP-A patients may have resulted in severe neurological symptoms. This phenomenon may be explained by a translocation of chromosome (1;10)(q25·3;q22·3) inherited from his father.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03611.x
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  • 4
    Digitale Medien
    Digitale Medien
    Micro-determination of cyclic AMP levels in human epidermis, dermis and hair follicles (1975)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 92 (1975), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In order to study the biological and possible pathological roles of cyclic adenosine 3′,5′-monophsphate (cyclic AMP) in the skin, it is mandatory to measure cyclic AMP in 50–100 μg of microdissected epidermis, dermis or appendages.In the present study, we ofter a method of extracting cyclic AMP from less than 100 μg of tissue, removing contaminating nucleotides and scaling down Gilman's method to fit the analysis of small amounts of tissue. Cyclic AMP levels in the dermis, epidermis, and hair follicles (bulbs) were approximately 1, 2 and 3.5 pmols/μg dry weight tissue respectively.This procedure is applicable to the measurement of cyclic AMP levels in limited foci of healthy or diseased skin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1975.tb03072.x
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  • 5
    Digitale Medien
    Digitale Medien
    Formation of low reverse current ion-implanted n+p junctions by low-temperature annealing (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 55 (1989), S. 966-968 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: By employing stress compensation technology in conjunction with an ultrahigh vacuum ion implanter, we have obtained two orders of magnitude smaller reverse-bias current levels in n+p junctions annealed at 550 °C as compared to the previous data. When samples are made with an optimum stress compensation condition, the magnitude of reverse-bias currents in n+p junctions as well as the carrier deactivation during post-implantation anneal becomes smallest. In order to further reduce the reverse-bias current level, it is shown that the elimination of contamination involvement during the implantation process is most essential.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.101691
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  • 6
    Digitale Medien
    Digitale Medien
    1-Pyrroline: The Odor Component of Strecker-Degraded Proline and Ornithine (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 30 (1965), S. 0 
    Details
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The odor component of proline and ornithine degraded by periodate, isatin, or ninhydrin was identified as 1-pyrroline by means of gas chromatography on three columns, mass spectra, and infrared analysis. Free γ-amino-butanal also yields the same odor component via formation of an internal Schiff base.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.1965.tb01875.x
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  • 7
    Digitale Medien
    Digitale Medien
    Collapse of single DNA molecule in poly(ethylene glycol) solutions (1995)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 102 (1995), S. 6595-6602 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: The compactization of a single DNA molecule in polyethylene glycol (PEG) solution was investigated both theoretically and experimentally. A theory is proposed taking into account the polyelectrolyte effect and redistribution of PEG within DNA coils. This approach makes it possible to describe the dependence of critical value, c, of PEG concentration at the point of DNA collapse on the degree of PEG polymerization, P, and on the concentration of low-molecular salt, ns. Observation of single DNA molecule in solution of PEG has been carried out by means of fluorescence microscopy which allows one to observe the conformation of individual DNA directly. Direct evidence that the coil–globule transition of DNA occurs as first order phase transition was obtained. It was confirmed that the critical concentration of PEG decreases with an increase of the degree of PEG polymerization and salt concentration. The width of the coexistence region of coil and globule was found to be dependent on salt concentration and degree of polymerization of PEG. It was found that DNA undergoes re-entrant globule–coil transition in concentrated solution of high-molecular weight PEG. These experimental results correspond well to the theoretical predictions. © 1995 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.469375
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  • 8
    Digitale Medien
    Digitale Medien
    Effects of short chain alcohols and hydrocarbon compounds on the adenylate cyclase of the skin (1976)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 94 (1976), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The cyclic AMP content of epidermal slices is increased by incubation with ethanol, the effect of which is dose-dependent from 1 to 5% concentration in the incubation media.n-Propanol and acetone are also effective at a concentration equimolar to 5% ethanol.Experimental results suggest that this effect of ethanol is due to activation of adenylate cyclase, rather than to the inactivation of cyclic AMP-phosphodiesterase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1976.tb05159.x
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  • 9
    Digitale Medien
    Digitale Medien
    Is the cyclic AMP in psoriatic epidermis low? (1975)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 93 (1975), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A deficiency of epidermal cyclic adenosine 3′, 5′-monophosphate (cyclic AMP) has been implicated as the cause of the incomplete differentiation, increased mitosis and increased glycogen concentration which characterize the psoriatic lesion. This communication contains our data on the epidermal concentration of cyclic AMP in the lesional and ‘normal’ (non-involved) skin of patients with psoriasis. In these studies we have introduced the following improvement in methodology: (1) Local ischaemia in the biopsy specimens was prevented by not giving any injections prior to removal of the tissues and by freezing the tissues prior to removal. (2) The epidermis was microdissected from the dermis prior to cyclic AMP assay so as to give as pure an epidermal specimen as possible.Epidermal cyclic AMP was found to be 20–25% higher in the skin lesion than in the uninvolved skin when compared on a dry weight or protein basis but essentially the same when compared on the basis of DNA content. Our conclusion is that the cyclic AMP level in the psoriatic lesion is not lower than that in the ‘normal’ skin and thus these characteristics in psoriatic lesions cannot be related simply to a cyclic AMP deficiency.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1975.tb06490.x
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  • 10
    Digitale Medien
    Digitale Medien
    On the lack of response to catecholamine stimulation by the adenyl cyclase system in psoriatic lesions (1975)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 92 (1975), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: When epidermis from the uninvolved skin of psoriatic patients was incubated for 5 min in Hank's medium containing adrenaline and theophyllinc, the cychc AMP level consistently increased 20-30 times over the level observed when adrenaline was not added to the medium. On the other hand, when epidermis from the involved skin of psoriatic patients was incubated under the same experimental conditions, the cyclic AMP level increased only 2–5 times. Even when thcophylline, an inhibitor of specific cyclic AMP-phosphodiesterase, was omitted from the medium, a clearly demonstrable difference in sensitivity to adrenaline was evident in normal appearing and lesional psoriatic epidermis. These results indicate a faulty adenyl cyclase system in the involved epidermis of psoriatic lesions rather than a defective degradation process by the specific phosphodiesterase. Since the Km for adrenaline activation of adenyl cyclase was approximately the same in both the uninvolved and the involved epidermis and since the cyclic AMP increase by adrenaline was abolished by the addition of propranolol, the basic nature of the β-receptor (specifically the binding affinity to adrenaline) in the involved epidermis does not appear to be defective. On the other hand, the finding that the Value, for adrenaline activation is 10–20 times higher in the uninvoled than in the involved epidermis suggests that the poor response in the involved epidermis may be due to fewer available binding sites for adrenaline in the psoriatic lesion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1975.tb03140.x
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