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  • 1
    Electronic Resource
    Electronic Resource
    Antibonding delocalization: geminal interaction of .sigma.-bonds and angle strain (1991)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 7144-7146 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00019a009
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  • 2
    Electronic Resource
    Electronic Resource
    Severe neurological abnormalities associated with a mutation in the zinc-finger domain in a group A xeroderma pigmentosum patient (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 131 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: All the reported Japanese patients with group A xeroderma pigmentosum (XP) have two or three mutations at codon 116 in exon 3, codon 228 in exon 6, and the splicing acceptor site of intron 3 of XP group A complementing (XPAC) gene. A homozygote (XP390S) with a nonsense mutation at codon 228 has less severe neurological abnormalities than patients with the splicing mutation at the acceptor site of intron 3. As homozygotes for the nonsense mutation at codon 116, which truncates a carboxyl-terminal site of XPAC protein at an early part of its zinc-finger domain, have not been reported previously, the possible severity of associated neurological abnormalities was not known. We report a group A XP patient, XP180S, who had neurological abnormalities which were more severe than those in patients homozygous for the splicing mutation. The polymerase chain reaction product from exon 3 of the patient's XPAC gene was digested completely into three fragments by MseI restriction endonuclease. Thus, the patient was homozygous for the mutation at codon 116.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb08562.x
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of pigmented granules in minocycline-induced cutaneous pigmentation: observations using fluorescence microscopy and high-performance liquid chromatography (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe a technique to facilitate histopathological detection and quantitative measurement of trace amounts of tissue minocycline.In a patient with minocycline-induced hyperpigmentation, a series of biopsies were taken from the affected skin over a period of 54 months, and examined for tissue minocyclinc deposition. Frozen sections treated with 1 m MgCl2-ethanol yielded minocycline-specific yellowish fluorescence, the location of which corresponded to clumps of granular deposits in the dermis. A decrease in the number of fluorescent granules correlated with the clinical resolution of hyperpigmentation and a significant decrease in the tissue minocycline level. Our data also provide further support for the concept that the pigment granules contain insoluble complexes of minocycline chelated with iron. The fluorescence technique is simple, sensitive, and reproducible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb03166.x
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  • 4
    Electronic Resource
    Electronic Resource
    Cutaneous oxalate granulomas in a haemodialysed patient: report of a case with unique clinical features (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 128 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a patient undergoing haemodialysis, who developed multiple subcutaneous nodules. Histology showed that the noduies were composed of deposits of crystals in the dermis, with an associated foreign-body reaction. The crystalline deposits were identified as calcium oxalate by histochemical staining, polarizing microscopy, and analytical electron microscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb00267.x
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural study of extramammary Paget's disease—histologically showing transition from bowenoid pattern to Paget's disease pattern (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 128 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Histoiogical, immunohistochemical, and ultrastructural studies were performed on two cases of histologically unusual extramammary Paget's disease. Histologically, the central area of the lesions showed a bowenoid pattern, and the peripheral area showed typical extramammary Paget's disease. The transition zone showed an intermediate pattern. All these areas were positive for CHA and EMA, and negative for S-100 protein. Ultrastructually. in the intermediate pattern, the tumour cells had abundant cytoplasmic glycogen, and the widened intercellular spaces contained numerous glycogen particles, which were probably secreted hy the tumour cells. It is well known that eccrine glands, but not apocrine glands, secrete glycogen particles. Therefore, the present findings suggest that some cases of extramammary Paget's disease are a proliferation of germinative cells with eccrine gland differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb15150.x
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  • 6
    Electronic Resource
    Electronic Resource
    Growth-inhibitory effects of 1,25-dihydroxyvitamin D3 on normal and psoriatic keratinocytes (1990)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 123 (1990), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the growth and DNA synthesis of cultured human keratinocytes obtained from involved and uninvolved psoriatic epidermis and normal epidermis were studied. Treatment with 10-8m and 10-7m of 1,25(OH)2D3 inhibited cell growth as follows: 58.5±19.3% and 21.3±13.6% in normal keratinocytes (n=6); 43.8±22.8% and 17.8±12.3% in psoriatic uninvolved keratinocytes (n=4); 51.7±18.2% and 13.2±6.4% in psoriatic involved keratinocytes (n=6). Inhibition was virtually complete at 10-6m. DNA synthesis was also inhibited by 10-8m, 10-7m and 10-6m of 1,25(OH)2D3 as follows: 70.0±8.3%, 59.0±6.8% and 16.7±4.0%, respectively, in normal keratinocytes (n=3); 78.5±13.5%, 51.5±25.5% and 24.5±21.5%, respectively, in psoriatic uninvolved keratinocytes (n=2); and 69.3±14.5%, 41.3±19.1% and 14.8±11.2%, respectively, in psoriatic involved keratinocytes (n=4). These results indicate that 1,25(OH)2D3 functions as a growth inhibitor for cultured human keratinocytes derived from both normal and psoriatic skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1990.tb01828.x
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  • 7
    Electronic Resource
    Electronic Resource
    Purpura caused by UV-irradiation at 375 nm in a patient with hydroa vacciniforme (1991)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 124 (1991), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1991.tb00613.x
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  • 8
    Electronic Resource
    Electronic Resource
    Plane elastic solution for the second mixed boundary value problem and its application (1994)
    Springer
    Archive of applied mechanics 64 (1994), S. 295-306 
    Details
    ISSN: 1432-0681
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Übersicht Die Lösung des zweiten gemischten Randwertproblems der ebenen Elastizität mit zwei kraftbeanspruchten und zwei gestützten Rändern wird dargestellt. Für die Analyse wird eine rationale Abbildung verwendet, die als Summe partieller Lösungen aus komplexen Spannungsfunktionen aufgebaut ist. Für gleichmäßige Zug- und Schubbeanspruchungen kann die Lösung in geschlossener Form dargestellt werden und ist verwendbar in Rißaufgaben der linear elastischen Bruchmechanik. Als Illustration der allgemeinen Lösung dient ein verzweigter Bereich der gegenseitigen Einwirkung einer quadratischen Öffnung mit Seitenkerbe und eines Risses. Die Spannungsverteilungen und Spannungsintensitäten werden dabei berechnet.
    Notes: Summary A solution is obtained for the second mixed boundary value problem with two boundaries loaded with external forces, and the other two boundaries simply supported. A rational mapping function formed as a sum of fractional expressions and complex stress functions is used for the analysis. A closed form solution can be obtained under uniform tensile and shearing loadings. These solutions are applicable to crack problems in linear elastic fracture mechanics. In order to illustrate the general solution, a double connected region is considered, in which interaction between a square hole with a crack extension and another crack is investigated. Stress distributions and stress intensity factors are obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788215
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  • 9
    Electronic Resource
    Electronic Resource
    Characterization of keratin peptide in sebaceous carcinomas (1993)
    Springer
    Archives of dermatological research 285 (1993), S. 241-244 
    Details
    ISSN: 1432-069X
    Keywords: Simple epithelial keratin ; Sebaceous carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372019
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  • 10
    Electronic Resource
    Electronic Resource
    Keratin specificity analyses of eight anti-keratin monoclonal antibodies, and their immunostaining patterns in normal skin using formalin-fixed and paraffin-embedded tissue specimens (1993)
    Springer
    Archives of dermatological research 285 (1993), S. 6-12 
    Details
    ISSN: 1432-069X
    Keywords: Anti-keratin monoclonal antibody ; Keratin specificity ; Immunohistochemistry ; formalin-fixed and paraffin-embedded tissue specimen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Keratin specificity analyses of eight anti-keratin antibodies (34ΒB4 (K1), 35ΒH11 (K8), Ks 13.1 (K13), Ks 19.1 (K19), PKK1, LP34 (CK1), KL1 and AE1) using keratin protein derived from normal thigh epidermis, normal parotid gland and a human squamous cell carcinoma cell line (HSC-5) were performed, and compared with those described in the data sheets. The reactivities of LP34, KL1 and PKK1 were markedly different from those mentioned in the data sheets. The immunostaining pattern of these antibodies in normal skin using formalin-fixed and paraffin-embedded tissue specimens was also examined. The staining patterns of suprabasal keratinocytes (K1, K13, CK1 and KL1 positive), basal cells of the epidermis (PKK1 and AE1 positive), inner cells of the ducts (K8, K13, CK1, KL1 and AE1 positive) and secretory cells of sweat glands (K8, K19, PKK1, KL1 and AE1 positive), mature cells (K8 and KL1 positive) and peripheral cells (CK1, KL1 and AE1 positive) of sebaceous glands and outer root sheaths (PKK1, CK1, KL1 and AE1 positive) were specific. Thus, we conclude that the differentiation of epidermis and skin appendages is possible by immunostaining with these eight anti-keratin antibodies using formalin-fixed and paraffin-embedded tissue specimens with proper protease pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370816
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