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  • 1
    Digitale Medien
    Digitale Medien
    Pharmacology of Antidiarrheal Drugs (1983)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 23 (1983), S. 279-301 
    Details
    ISSN: 0362-1642
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.pa.23.040183.001431
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  • 2
    Digitale Medien
    Digitale Medien
    Mydriatic activity of analgesics in mice (1956)
    Springer
    Cellular and molecular life sciences 12 (1956), S. 293-294 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Résumé Dans une série de 20 analgésiques puissants nous avons trouvé une correlation hautement significative entre l'activité analgésique et mydriatique chez la souris.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02159614
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  • 3
    Digitale Medien
    Digitale Medien
    Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1657-1659 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Oxatomide is a new potent inhibitor of anaphylactic and allergic reactions. After oral administration, the compound both inhibits the release of endogenous histamine and prevents the effects of exogenous histamine, at comparable doses. The combination of these effects appears to be the basis of the effectiveness of oxatomide in allergic reactions and may lead to clinical applications different from classical antihistaminics and from cromoglycate.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01934056
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  • 4
    Digitale Medien
    Digitale Medien
    Antiemetic effect of haloperidol in the dog as related to plasma level and dose (1981)
    Springer
    Psychopharmacology 75 (1981), S. 240-244 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Haloperidol ; Plasma concentration ; Antiemetic effect ; Dog
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A positive and highly significant correlation was found between SC dose, plasma concentration, and antiemetic effect of haloperidol in the dog. To protect dogs from apomorphine-induced emesis, a concentration of 1 ng haloperidol/ml plasma was always sufficient, whereas protection from emesis was never obtained with plasma levels lower than 0.53 ng/ml. The elimination rate of haloperidol from plasma varied from 1.53 to 2.60 among different animals. Thus, the interindividual variability to haloperidol was surprisingly low. Antiemetic effect and plasma elimination of haloperidol were not related to body weight.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00432431
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  • 5
    Digitale Medien
    Digitale Medien
    A putative multipartite model of haloperidol interaction in apomorphine-disturbed behavior of the dog (1978)
    Springer
    Psychopharmacology 59 (1978), S. 255-258 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Dog ; Self-stimulation ; Apomorphine ; Haloperidol ; Stimulus control
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The interaction between various doses of apomorphine and haloperidol on intracranial self-stimulation in the dog was studied using a pradigm in which reinforcing brain-stimulation was controlled by a discriminative auditory stimulus. Reinforced leverpressing was decreased by low doses of apomorphine and completely suppressed by stereotypogenic doses. At various doses of apomorphine, low doses of haloperidol either increased response inhibition by enhancing stereotypy, or increased lever pressing by reducing stereotypy while concomitantly increasing the number of nonreinforced responses. Intermediate to relatively high doses of haloperidol antagonized stereotypy and the response inhibition produced by apomorphine. High doses of haloperidol antagonized stereotypy but also suppressed self-stimulation. Thus, haloperidol is not only able to restore performance capability, but also disturbed reinforcing and discriminative stimulus control.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00426630
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  • 6
    Digitale Medien
    Digitale Medien
    Bromperidol, a new butyrophenone neuroleptic: A review (1982)
    Springer
    Psychopharmacology 78 (1982), S. 1-7 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Bromperidol ; Haloperidol ; Chlorpromazine ; Preclinical review ; Animal pharmacology ; Animal pharmacokinetics ; Animal biotransformation ; Animal drug safety
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This review compares and contrasts the preclinical pharmacology of bromperidol with another butyrophenone neuroleptic, haloperidol, and the phenothiazine neuroleptic chlorpromazine. Its pharmacokinetics, biotransformation, and safety in several laboratory animal species are also summarized. These preclinical data support its use as an antipsychotic agent and show that it is well absorbed following oral administration with an apparent elimination half-life of approximately 24 h, supporting a once-daily dose regimen. Animal toxicity (including acute- and multiple-dose toxicology and reproductive and mutagenicity studies) show that bromperidol is well tolerated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00470578
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  • 7
    Digitale Medien
    Digitale Medien
    Behavioral and 5-HT antagonist effects of ritanserin: A pure and selective antagonist of LSD discrimination in rat (1985)
    Springer
    Psychopharmacology 86 (1985), S. 45-54 
    Details
    ISSN: 1432-2072
    Schlagwort(e): 5-HT antagonist ; LSD antagonist ; Drug discrimination ; Anxiety ; 5-HTP ; Head twitch ; Conflict behavior ; Hypothermia ; Ritanserin ; Pirenperone ; Chlordiazepoxide ; Diazepam ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The newly synthesized compound and putative 5-HT2 antagonist ritanserin, but not the structurally related compound R 56413, resembles pirenperone in that it acts as a pure antagonist in an LSD-saline drug discrimination assay in the rat. Ritanserin exceeded pirenperone in terms of behavioral specificity; the lowest effective dose of ritanserin in antagonizing LSD was one order of magnitude higher than that of pirenperone, but the compound depressed rate of operant responding only at doses that were about 1000-fold higher than those at which pirenperone was effective. Ritanserin exerted effects in an open field test which were reminiscent of anxiolytic drug activity in the rat; its effects were greater than those of pirenperone, R 56413 and the benzodiazepines chlordiazepoxide and diazepam. The results of experiments on antagonism of 5-HT-induced hypothermia and of the 5-HTP-induced headtwitch response fail to support the possibility that the putative anxiolytic effects of ritanserin in the rat can be ascribed simply to a pharmacologically defined action at 5-HT receptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00431683
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  • 8
    Digitale Medien
    Digitale Medien
    Haloperidide ( R 3201), a Highly Potent and Selective Anti-emetic Agent in Dogs (1961)
    [s.l.] : Nature Publishing Group
    Nature 190 (1961), S. 911-912 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Both haloperidol and perphenazine are potent inhibitors of the emetic effect of apomorphine in dogs2"3'5. After subcutaneous injection, haloperidol has a quicker onset and a considerably longer duration F--C-CH-CH O Haloperidide (R 3201): R = -C-N; R' = w-Cl Haloperidol (R 1625): R = OH; R' = ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/190911a0
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  • 9
    Digitale Medien
    Digitale Medien
    Levocabastine: Pharmacological profile of a highly effective inhibitor of allergic reactions (1992)
    Springer
    Inflammation research 35 (1992), S. 12-18 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Levocabastine, selected from a series of cyclohexylpiperidine derivatives protects rats from compound 48/80-induced anaphylactic shock for at least 16 h at the oral dose of 0.0015 mg/kg. At the same dose histamine skin reactions and at slightly higher doses passive cutaneous anaphylactic reactions are inhibited. Blockade of passive cutaneous anaphylactic reactions is obtained with levocabastine, despite absence of peripheral serotonin antagonism and any other known non-specific action that may facilitate inhibition of passive anaphylaxis. In dogs allergic reactions are inhibited at oral doses 40 times lower than ketotifen. In guinea-pigs orally and topically administered levocabastine are remarkably effective against allergic conjunctivitis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01990945
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  • 10
    Digitale Medien
    Digitale Medien
    The pharmacological profile of a specific, safe, effective and non-sedative anti-allergic, astemizole (1986)
    Springer
    Inflammation research 18 (1986), S. 141-144 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In the compound 48/80 lethality test in rats, which is based on the specific activation of mast cells, astemizole was selected as a potent, long-acting and orally very effective inhibitor of anaphylactoid shock. In comparison to other histamine-H1 antagonists astemizole was also a very effective inhibitor of allergic reactions in rats and dogs and remarkably free of non-specific interactions with other biological amines and normal body functions. In numerous tests no evidence of central activity was found and toxicity studies have shown astemizole to be a very safe drug despite of its long duration of action. A daily dose of 10 mg of astemizole was found clinically free of side-effects and more effective than conventional antihistamine treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01988005
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