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  • 1995-1999  (7)
  • 1980-1984  (5)
  • 1965-1969  (1)
  • 1
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 9189-9193 
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1399-0047
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: We have synthesized a series of non-macrocyclic ligands to FKBP12 that are comparable in binding potency and peptidyl prolyl isomerase (PPIase) inhibition to FK506 itself. We have also solved the structure of one of these ligands in complex with FKBP12, and have compared that structure to the FK506–FKBP12 complex. Consistent with the observed inhibitory equipotency of these compounds, we observe a strong similarity in the conformation of the two ligands in the region of the protein that mediates PPIase activity. Our compounds, however, are not immunosuppressive. In the FKBP12–FK506 complex, a significant portion of the FK506 ligand, its `effector domain', projects beyond the envelope of the binding protein in a manner that is suggestive of a potential interaction with a second protein, the calcium-dependent phosphatase, calcineurin, whose inhibition by the FKBP 12–FK506 complex interrupts the T-cell activation events leading to immunosuppression. In contrast, our compounds bind within the surface envelope of FKBP12, and induce significant changes in the structure of the FKBP12 protein which may also affect calcineurin binding indirectly.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    The European physical journal 296 (1980), S. 35-42 
    ISSN: 1434-601X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract We estimate the accuracy of the conventional ansatz of approximating the lowest order absorptiveP-wave pion-deuteron interactions by pole term amplitudes. By comparing the matrix elements of the approximate pole term and complete absorptive reaction amplitudes for elasticπd scattering we find the pole term approximation to lead to better than 10% accuracy for both theP 11 andP 33 state interactions.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Microchimica acta 57 (1969), S. 480-489 
    ISSN: 1436-5073
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die Flüssigkeits-Szintillationszählung zur Bestimmung von14C-markiertem Ametryn in Dünnschichtchromatogrammen wurde eingehend geprüft. Alterung, Löschungseffekt von Trägersubstanz und Adsorptionsmitteln, Temperaturbeständigkeit der Verbindung in adsorbiertem Zustand wurden untersucht. Die Reproduzierbarkeit beträgt 1 bis 2%, die Nachweisgrenze 0,005μg pro Tüpfel, das Signal-Hintergrund-Verhältnis 3∶1. Zur Lokalisierung der Flecken wurde die Fluoreszenzlöschung herangezogen. Die Ausbeute nach 30 Minuten Entwicklung auf Silikagelplatten war ungefähr 90% Ametryn, unabhängig vom Laufmittel. Bei zweidimensionaler Arbeitsweise wurden 75% wiedergefunden. Die Ausbeute aus Wasser- und Bodenproben lag zwischen 78 und 88%.
    Notizen: Summary The use of the liquid scintillation counting method for the determination of14C labelled ametryne on thin-layer chromatograms has been thoroughly investigated. Aging, quenching effect of carrier and adsorbents as well as temperature stability of the compound in the adsorbed state have been studied. The method has a reproducibility of 1 to 2% and a detection limit of 0.005μg per spot at a 3 ∶ 1 signal to background ratio. Fluorescence quenching was used for the location of spots on the chromatogram. Recovery studies were carried out by this method. After 30 minutes development on a chromatoplate coated with silicagel, about 90% of the ametryne was recovered independent of solvent system used. About 75% of the ametryne was recovered from a two-dimensional chromatogram. Recoveries of ametryne from water and soil samples ranged between 78 and 88%.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    facet.materialart.
    Unbekannt
    London : Periodicals Archive Online (PAO)
    Journal of theological studies. n.s.:35 (1984) 71 
    ISSN: 0022-5185
    Thema: Theologie und Religionswissenschaft
    Notizen: ARTICLES, NOTES, AND STUDIES
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Marine biology 83 (1984), S. 95-102 
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Specimens of the thiobiotic acoel Solenofilomorpha funilis Crezée, 1975 and the oxybiotic acoel Otocelis sp. were collected from Mount Desert Island, Maine, USA in spring and summer of 1982, and the ultrastructure and distribution of their mitochondria were compared. The volume density and the surface density of the mitochondria are significantly higher in the epidermis and parenchyma of S. funilis than in the corresponding tissues of Otocelis sp. Surface densities of mitochondrial cristae are higher in all tissues studied (epidermis, muscle, and parenchyma) of S. funilis than in Otocelis sp. The differences in mitochondrial ultrastructure of these two species suggest that mitochondria in anaerobic tissues differ in function from their aerobic counterparts.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Digestive diseases and sciences 42 (1997), S. 404-407 
    ISSN: 1573-2568
    Schlagwort(e): IRRITABLE BOWEL SYNDROME ; UROLOGICAL SYMPTOMS
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Irritable bowel syndrome patients often complainof urinary symptoms such as frequency, urgency, anddysuria, raising the possibility of inappropriatereferral to the urologist. To resolve this issue, the prevalence of irritable bowel syndrome wascompared in patients attending urological and controlclinics (dermatology and ENT). The overall prevalence ofirritable bowel syndrome was 31.2% in the urological clinic compared with 21.2% in the controls (P〈 0.001), but striking differences emerged, dependingon presenting complaint. Irritable bowel symptoms wereparticularly common in patients presenting with loin pain (male: 40.9%, P = 0.004; female: 50%, P =0.03), dysuria (male: 43.8%, P = 0.007; female: 46.2%,P = 0.01) and frequency/urgency (male: 31.7%, P = 0.002;female: 42.4%, P = 0.006), and the male/femaleprevalence was 24% and 44%. These results suggest that inirritable bowel syndrome, urinary symptoms includingloin pain can present diagnostic dilemmas in both thegastroenterological and urological setting, underlining the importance of specialists in these fieldsworking together in order to define better ways ofmanaging such patients.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Rheologica acta 21 (1982), S. 413-415 
    ISSN: 1435-1528
    Schlagwort(e): Strain-rate history effect ; dynamic torsional loading ; single-crystal ; dislocation arrangement ; Kolsky bar
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: Abstract Single crystals of LiF and Al are deformed in shear at a number of constant strain-rates in the range 10−4 to 1600 s−1. These constant rate tests are supplemented by a series of jump tests in which a sharp increment in strain rate is imposed during the quasi-static straining. Dislocation arrangements are observed by etch-pits technique for LiF crystals and by TEM for Al crystals. It is shown that cell sizes vary inversely with flow stress and strain-rate sensitivity.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Journal of radioanalytical and nuclear chemistry 211 (1996), S. 173-179 
    ISSN: 1588-2780
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Energietechnik
    Notizen: Abstract The phase behaviour of carbon dioxide confined in VYCOR glass at pressures below that of the bulk triple point (∼0.51 MPa) has been investigated. The temperature at which freezing occurs appears to be pressure dependent below 0.3 MPa. As experiments are performed at successively lower pressures, the confined phase transitions gradually disappear, due to either partial pore filling, or the proximity of the confined triple point.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Journal of radioanalytical and nuclear chemistry 211 (1996), S. 165-171 
    ISSN: 1588-2780
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Energietechnik
    Notizen: Abstract In confined (nanometer-scale) geometry, the effects of substrate forces and finite size produce a shift of the gas ⇔ liquid phase boundary from that found in corresponding bulk. The pore transitions also show marked hysteresis. The phase behaviour of a binary gas mixture in confined geometry is likely to depend on the miscibility of the system and the interaction between the substrate and the individual fluid molecules/atoms. Here, we present the results of a pilot positronium annihilation study of the condensation and evaporation of argon-nitrogen mixtures confined in ∼4 nm diameter cylindrical pores in VYCOR glass.
    Materialart: Digitale Medien
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