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  • 1
    Electronic Resource
    Electronic Resource
    Volatiles of Apples During Storage and Ripening (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 30 (1965), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1965.tb01778.x
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  • 2
    Electronic Resource
    Electronic Resource
    SETTING TIME AND SETTING TEMPERATURE OF PECTIN JELLIES (1960)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 25 (1960), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1960.tb00008.x
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  • 3
    Electronic Resource
    Electronic Resource
    Involvement of inferior turbinate mucosa in chronic sinusitis – localization of T-cell subset (2000)
    Copenhagen : Munksgaard International Publishers
    Allergy 55 (2000), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: In chronic sinusitis (CS), different subsets of leukocytes are involved in development of persistent inflammation of the nasal mucosa. The localization and differentiation of these infiltrating lymphocytes may help us to understand the inflammatory interactions in the epithelium, lamina propria, and seromucous glands of the nasal mucosa in CS. Methods: We examined frozen sections of inferior turbinates from 14 patients with nonallergic CS and 10 normal nonallergic controls. We used the avidin-biotin-peroxidase (ABC) technique with monoclonal antibodies against CD3 (total T cells), CD4 (T-helper/inducer cells), CD8 (T-suppressor/cytotoxic cells), CD22 (B cells), CD56 (natural killer cells), elastase (neutrophil granulocytes), eosinophil cationic protein (eosinophil granulocytes), and CD68 (macrophages). Results: We found significant increases (P〈0.05) of CD3, CD4, and CD8 T cells and B cells in the nasal mucosa of patients with CS. The number of CD68 cells and eosinophils showed no significant rise. Conclusions: The different types of leukocytes play a key role in the defense of the respiratory tract. The analysis of the distribution of cells in the epithelium, mucosa, and glands of the inferior turbinate confirmed that nonallergic CS is, in fact, chronic, bacterial rhinosinusitis involving the inferior turbinates, and that the pathomechanism is therefore different from that of nasal polyposis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2000.00411.x
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  • 4
    Electronic Resource
    Electronic Resource
    Hochmalignes T-Zell-Non-Hodgkin-Lymphom (nasal type) des harten Gaumens (2000)
    Springer
    HNO 48 (2000), S. 318-322 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter ; Nasales T-Zell-Lymphom ; Letales Mittelliniengranulom ; Wegener-Granulomatose ; Keywords ; Nasal T-cell lymphoma ; Lethal midline granuloma ; Wegener’s granulomatosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The monomorphic clinical aspect of destructive mid-face lesions is characterised by inflammation, induration and granulomatous transformation. This feature can be caused by various infections, toxical noxa, Wegener’s Granulomatosis and different neoplasms. The case of a 19 year old patient with EBV associated nasal type T-cell lymphoma located at the hard palate is presented. The diagnostic approach and difficulties in diagnosing this entity assessing by using multiple biopsies, serological and molecularbiological detection of EBV association and immunohistochemistry for atypic T-cells are elucidated. In the presented case the treatment with chemotherapy and irradiation following a well-defined therapy concept leaded to a three year recurrence-free survival so far. The comparison of the key-histological findings and the major differential diagnoses is mandatory to establish the final diagnosis of lymphoma. This is the basement for treating this disease with combined chemotherapy and irradiation for optimizing survival.
    Notes: Zusammenfassung Das klinisch weitgehend monomorphe Bild eines destruktiven Mittelgesichtprozesses ist gekennzeichnet durch Veränderungen in Folge von Entzündung, Infiltration und granulomatösen Umbauvorgängen. Am Fall eines 19jährigen Patienten mit einem seltenen EBV-assoziierten hochmalignen Non-Hodgkin-T-Zell-Lymphom am harten Gaumen werden die Schwierigkeiten bis zur endgültigen Diagnosefindung dargestellt. Anhand der Literatur werden die unterschiedlichen Begriffsdefinitionen von destruierenden Mittelgesichtsveränderungen verschiedener Autoren aufgezeigt. Nur über eine differenzierte klinische, mikrobiologische, serologische und histologische Diagnostik ist eine Abgrenzung gegenüber verschiedenen Infektionen, toxischen Noxen, der Wegener-Granulomatose und diversen Neoplasien zu erreichen. Hierdurch wird die überlebenswichtige Kombinationstherapie aus Chemotherapie und Bestrahlung möglich.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050573
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  • 5
    Electronic Resource
    Electronic Resource
    Closure of Recurrent Frontal Skull Base Defects with Vascularized Flaps – A Technical Case Report (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 1353-1358 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: CSF rhinorrhea; skull base defects; vascularized flaps.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Techniques for vascularized reconstruction of the anterior cranial fossa floor defects causing recurrent cerebrospinal fluid fistula are discussed in this report. The closure employs the use of local random- or axial-pattern vascularized flaps in simple cases. In complicated cases (for instance, status after repeated exploration) the tissue of the cranial base is severely compromised and shows low potential for healing. Non-vascularized grafts only add avital scars to the already present ones leading to recurrent fistulas. Free vascularized flaps show more mechanical strength and less scar contraction, resistance to infections and survive better in a compromised surrounding, thus leading to long term sealing in such cases. The technical issues of vascularized closure of defects of the frontal skull base are discussed in this report.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010070004
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  • 6
    Electronic Resource
    Electronic Resource
    Sjoegren's syndrome: MR imaging of the parotid gland (1996)
    Springer
    European radiology 6 (1996), S. 46-51 
    Details
    ISSN: 1432-1084
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To date, myoepithelial sialoadenitis (Sjoegren's syndrome) has been diagnosed with sialography and other techniques. First results of MR imaging offer new possibilities in the diagnostic imaging of this Thirty-six pat nts with immunohistologically and serologically confirmed Sjoegren s syndrome and 25 patients suffering from other diseases, included as a control group, were examined by MR in transverse and coronal orientation T-2 weighted sequneces (TR/TE- 1600/25/90) and T- weighted sequences (TR/TE 500/25 msplainand after (Gd-DTPA administration were obtained. In all patients the parotid gland showed characteristics internal paterns and abnormalities in gland size. There was a 21 nonhomogeneous internal pattern wit a characteristicsc speckled, honeycomb-like appearance visible especially on T2-weighted sequences. Enhancement with Gd-DTPA yielded no additional information. A staging system with four stages of Sjoegren's syndrome (no characteristics changes to a nodular and swollen gland) was developed. Magnetic resonance has become an important new tool in assessing parotid gland changes in patients suffering from Sjoegren's syndrome, and could well replace the more invasive and unpleasant diagnostic methods in the near future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00619951
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  • 7
    Electronic Resource
    Electronic Resource
    3D MR imaging with Gd-DTPA in head and neck lesions (1991)
    Springer
    European radiology 1 (1991), S. 151-157 
    Details
    ISSN: 1432-1084
    Keywords: 3D-MRI ; ray-tracing ; head nad neck ; 3D-reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three-dimensional MR imaging technique is not a new concept, however, there is very little experience concerning clinical trials. Especially in head and neck lesions, the accuracu of this new imaging method has not yet been tested. A pilot study was performed to evaluate the diagnostic value of demonstrating the head and neck lesions and topographical structures implemented in a three-dimensional reconstruction of the entire head. The 3D reconstruction mode is based on the ray-tracting model. The application of the contrast medium Gd-DTPA proved to be helpful. Three-dimensional reconstruction revealed clear topographic details of the lesions, including the spread of infiltration and destruction of soft tissue. Additionally, the simultaneous view of multiple slices in different orientations is an ideal method for evalauting the spread of the lesion and to visualize the relation between lesion and surrounding tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451299
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  • 8
    Electronic Resource
    Electronic Resource
    Klinische Differentialdiagnostik von Erkrankungen der Mundhöhle und des Oropharynx (1996)
    Springer
    Der Radiologe 36 (1996), S. 181-187 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Mundhöhle ; Oropharynx ; Entzündungen ; Tumoren ; Diagnostik ; Therapie ; Key words Oral cavity ; Oropharynx ; Inflammation ; Tumors ; Diagnostic management ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the present paper, common disorders of the oral cavity and oropharynx are described with special emphasis on differential diagnostic aspects. The first part of this presentation covers different inflammatory diseases, mainly focusing on complications like peritonsillar, para- and retropharyngeal abscesses, and Ludwig's angina. These clinical entities can lead to further life-threatening complications, including deep neck infections and mediastinitis. The diagnostic value and necessity of modern imaging in these cases are emphasized. In the second part, the author reports on the incidence, etiology and clinical course of tumors of the oral cavity and oropharynx with special regard to malignancies. Tumors in these areas have been increasing in number over the past decades mainly due to changes in alcohol and nicotine consumption in the developed countries. Diagnostic management includes a thorough clinical evaluation as well as modern imaging for tumor delineation and possible bone infiltration, depending on the site of the original tumor. In addition, therapeutic considerations are discussed, focusing on surgical tumor removal and soft tissue replacement using different pedicled flaps and free flaps. It is also emphasized that postoperative radiotherapy is mandatory in most malignant tumors in this area.
    Notes: Zusammenfassung In der vorliegenden Arbeit werden verschiedene klinisch relevante Krankheitsbilder in Mundhöhle und Oropharynx unter differentialdiagnostischen Aspekten vorgestellt. Um die Thematik übersichtlich zu gestalten, wird auf eine Besprechung von Erkrankungen dieser Region verzichtet, die selten sind oder den Hals-Nasen-Ohrenarzt nicht betreffen. Im einzelnen wird zunächst die Klinik, Diagnostik und Therapie von Entzündungen angesprochen. In diesem Zusammenhang werden v. a. Komplikationen wie z. B. Para-, Retropharyngealabszeß, Mundbodenabszeß und Zungengrundabszeß vorgestellt, weil diese Krankheitsbilder u. U. zu weiterreichenden Komplikationen führen können und den bildgebenden Verfahren dann eine Schlüsselstellung in der Diagnostik zukommt. Im 2. Abschnitt erfolgt eine Darstellung der malignen Tumoren von Mundhöhle und Oropharynx. Diese Erkrankungen haben in den vergangenen Jahren zunehmend an Bedeutung gewonnen. Ätiologische, diagnostische und therapeutische Aspekte werden erläutert, wobei die Fragestellungen für bildgebende Verfahren in den einzelnen Regionen formuliert werden. Außerdem wird in diesem Zusammenhang auch auf die operativen Möglichkeiten, insbesondere die Weichteildeckung größerer Gewebedefekte, eingegangen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050058
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  • 9
    Electronic Resource
    Electronic Resource
    Computertomographie von Malignomen des Cavum oris, des Oro- und Hypopharynx und deren Ausbreitungswege (1996)
    Springer
    Der Radiologe 36 (1996), S. 193-198 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter CT ; Malignome ; Mundhöhle ; Oropharynx ; Hypopharynx ; Staging ; Key words CT ; Malignancy ; Oral cavity ; Oropharynx and hypopharynx ; Staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Carcinomas of the oral cavity, oropharynx and hypopharynx represent 5 % of all malignant neoplasms. The vast majority, over 90 %, are squamous cell carcinomas; less common are lymphomas and tumors of the minor salivary glands. In general, the clinical findings already suggest the presence of a tumor. Therefore, the role of imaging is precise tumor localisation and staging of the malignancy. CT is still the gold standard, although MRI is gaining more importance. We present the CT apperance of most frequent malignancies of the oral cavity, oro- and hypopharynx, discussing briefly the pertinent anatomy.
    Notes: Zusammenfassung Tumoren von Mundhöhle, Oro- und Hypopharynx stellen 5 % aller Malignome dar. Epitheliale Tumore sind dabei in der Überzahl, Lymphome und Tumoren der Speicheldrüse eher selten. Aufgrund der Symptomatik und der klinischen Untersuchung ist die Tumorerkrankung im Regelfall schon bekannt. Die wichtigste Aufgabe der bildgebenden Verfahren besteht deshalb darin, eine exakte Tumorlokalisation und ein möglichst genaues Staging zu erreichen. Die CT ist dabei immer noch das Verfahren der ersten Wahl, wenn auch die MRT zunehmend an Bedeutung gewinnt. Die zum Verständnis der Bildinterpretation wichtigen anatomischen Strukturen von Cavum oris, Oro- und Hypopharynx werden vorgestellt, die standardisierten CT Untersuchungsverfahren erläutert und die wichtigsten Pathologien vorgestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050060
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  • 10
    Electronic Resource
    Electronic Resource
    Wertigkeit der fettsignalunterdrückenden MRT-Pulssequenzen für die Diagnostik maligner Tumoren im Kopf-Hals-Bereich (1996)
    Springer
    Der Radiologe 36 (1996), S. 199-206 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter MRT ; Fettunterdrückung ; Kopf- Hals-Tumoren ; Malignome ; Key words MRI ; Fat suppression ; Head tumors ; Neck tumors ; Malignancies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: Evaluation of frequency-selective fat saturation (FS) and short-tau inversion recovery (STIR) fat suppression (FU) in MRI of patients with malignant head and neck tumors. Methods: Forty-five patients with biopsy-proven carcinomas of the extracranial head and neck were examined with MRI at 1.0 T. A T 2-weighted TSE sequence with and without STIR-FU and a T 1-weighted SE sequence with and without FS were compared in axial slices. Results: STIR-FU was successful in all and FS in 85–88 % of the head examinations (nasopharynx, sinuses, oropharynx, and oral cavity) and 33–46 % of the neck examinations (hypopharynx and larynx). When visualization and delineation of tumors were ranked on a four-point scale (0–3), respective mean values for images with/without FU or FS were 2.6/1.9 for T 2-TSE in all examinations, 2.2/1.7 (nasopharynx and sinuses) and 1.3/1.4–1.6 (oropharynx, oral cavity, hypopharynx, and larynx) for T 1-SE without contrast media administration (CM) and 2.3/2.1 (nasopharynx and sinuses) and 2.4–2.5/1.9–2.0 (oropharynx, oral cavity, hypopharynx, and larynx) with CM. Conclusions: STIR-T 2-TSE was a technically reliable pathfinder for localization and extension of both tumors and lymph nodes. FS-T 1-SE was technically unreliable in examinations of the hypopharynx and larynx. With CM, FS-T 1-SE was most useful for MRI of carcinomas of the oral cavity and oropharynx. In the nasopharynx and sinuses, T 1-SE with CM and FS-T 1-SE with or without CM were equal for tu- mor visualization and delineation.
    Notes: Zusammenfassung Von den verschiedenen Techniken der Fettsignalunterdrückung finden bei der MRT des Kopf-Hals-Bereichs v. a. die STIR-Fettunterdrückung und die frequenzselektive Fettsignalsättigung Anwendung. In eigenen MRT-Untersuchungen bei 1,0 T an 45 Patienten mit malignen Tumoren der extrakraniellen Kopf-Hals-Region führte die technisch einfachere STIR-Methode bei T 2-gewichteten Turbospinecho-(TSE-) Aufnahmen zu einer Verbesserung der Tumorerkrankung und -abgrenzung von 37–44 % in Abhängigkeit von der Tumorlokalisation. Die aufwendigere frequenzselektive Fettsignalsättigung war bei Kopfuntersuchungen technisch deutlich erfolgreicher als bei Halsuntersuchungen (85–88 % bzw. 33–46 %). Bei kontrastverstärkten T 1-gewichteten Spinecho-(SE-) Sequenzen verbesserte die frequenzselektive Fettsignalsättigung die Tumorerkennung und -abgrenzung im Oropharynx, in der Mundhöhle, im Hypopharynx und im Larynx um 25 %. Im Nasopharynx und in den Nasenhaupt- und -nebenhöhlen waren die kontrastverstärkten T 1-SE-Sequenzen mit und ohne Fettsättigung der nativen, fettgesättigten T 1-SE-Sequenz gleichwertig. STIR-T 2-TSE-Aufnahmen eignen sich v. a. zur Lokalisation von Tumoren und Lymphknoten, während frequenzselektiv fettsignalgesättigte T 1-SE-Sequenzen mit Kontrastverstärkung v. a. im Oropharynx und in der Mundhöhle vorteilhaft sind.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050061
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