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  • 1
    Digitale Medien
    Digitale Medien
    TOPOGRAPHIC DETERMINATION OF ZINC IN HUMAN BRAIN BY ATOMIC ABSORPTION SPECTROPHOTOMETRY (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 15 (1968), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Atomic absorption spectroscopy was used for measuring the zinc content, in ppb (μg/1), of brain tissue. A new method for determining the correction factor of atomic absorption interference is described.Measurements of the zinc content of twenty-four regions of adult human brains showed the maximum zinc content in resistent sector and endplate of the Amnion's horn, corroborating the histochemical data. The distribution of zinc in other regions was relatively uniform, but white matter showed lower values than gray matter. The zinc content of seventeen regions of human newborn brains was below that in adult brains, for all regions. The blood content of brain tissue contributed only insignificantly to its zinc content.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1968.tb08967.x
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  • 2
    Digitale Medien
    Digitale Medien
    HISTOCHEMICAL INVESTIGATIONS ON SUCCINIC DEHYDROGENASE IN THE CENTRAL NERVOUS SYSTEM—I (1959)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 4 (1959), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1959.tb13179.x
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  • 3
    Digitale Medien
    Digitale Medien
    HISTOCHEMICAL INVESTIGATIONS ON SUCCINIC DEHYDROGENASE IN THE CENTRAL NERVOUS SYSTEM—II (1959)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 4 (1959), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1959.tb13180.x
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  • 4
    Digitale Medien
    Digitale Medien
    Extradural spinal angiolipoma with secretory activity (1985)
    Springer
    Virchows Archiv 406 (1985), S. 253-259 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Extradural-intraspinal angiolipoma ; Secretory activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The light and ultrastructural analyses of an extradural intraspinal angiolipoma causing symptoms of spinal cord compression, are reported. The tumour showed morphological evidence of an endocrine-like secretory activity of fat cells, with an apparent mechanism of secretory function that has not previously been described for angiolipomas. The secretory granules, containing a lipid-like material, were covered with a continuous basement membrane originating from the basement membrane of the adipocyte.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00737090
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  • 5
    Digitale Medien
    Digitale Medien
    Computed tomography in neuronal ceroid lipofuscinosis (1980)
    Springer
    Neuroradiology 19 (1980), S. 35-38 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Cerebral computed tomography ; Neuronal ceroid lipofuscinosis ; White matter disease ; Metabolic brain disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The computed tomography (CT) findings in a verified case of neuronal ceroid lipofuscinosis (NCL) are presented. CT revealed diffuse and severe cerebral atrophy, reflected by generalized subarachnoid space enlargement and symmetric ventricular dilation. There was no evidence of abnormalities of the white matter. The CT features in our case of NCL correspond perfectly with the neuropathologic changes of the disease mentioned in the literature. Furthermore, CT is of considerable help in differentiating between those inherited metabolic brain diseases characterized primarily by white matter involvement and those presenting predominantly with changes of grey matter.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00369086
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  • 6
    Digitale Medien
    Digitale Medien
    Residual lesions of cerebral fat embolism (1977)
    Springer
    Journal of neurology 216 (1977), S. 227-233 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Atrophy of white matter ; Cerebral fat embolism ; Coma, posttraumatic ; Dementia, posttraumatic ; Demyelination ; Residual lesions of cerebral fat embolism ; Ventricular enlargement
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Ein Fall von Spätläsionen nach massiver zerebraler Fettembolie zeigt zahlreiche fleckförmige Nekrosen und Zonen von Demyelinisierung der weißen Substanz der Großhirn- und Kleinhirnhemisphären und des Hirnstammes. Auf die Bedeutung dieser Läsionen für die Entstehung eines posttraumatischen Coma oder posttraumatischen Demenz wird hingewiesen.
    Notizen: Summary Necropsy findings of a case which survived for three months after massive cerebral fat embolism are presented. The lesions are charcterized by numerous patchy necroses and areas of demyelination in the white matter of cerebral and cerebellar hemispheres and brain stem, accompanied by atrophy of white matter and ventricular enlargement. Attention is drawn to the significance of these lesions for posttraumatic coma or dementia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00314047
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  • 7
    Digitale Medien
    Digitale Medien
    Striato-nigral astrocytic melanization (1979)
    Springer
    Journal of neurology 220 (1979), S. 149-156 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Melanin ; Astrocytic melanization ; Striato-nigral degeneration ; Catecholamine metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Bericht über 2 nicht verwandte Patientinnen, die eine abnormale Pigmentierung des Striatum und der Substantia nigra zeigten. Beide litten an debilitierenden Gelenkerkrankungen, aber hatten keine Geschichte neurologischer Symptomatik. Das abnormale Pigment fand sich in Astrocyten und hatte die histochemischen Eigenschaften und die Feinstruktur von Melanin. Die Veränderungen weisen auf eine Störung des Katecholaminstoff-wechsels hin, wobei offen bleibt, of dieselbe endogen ist oder auf unbekannten exogenen Faktoren beruht.
    Notizen: Summary Abnormal pigmentation was found in the striatum, pallidum and substantia nigra of two unrelated patients. Both had suffered from debilitating joint disease; there was no evidence of a progressive neurologic disorder. The pigment was localized in astrocytes and had the histochemical and electron microscopic features of melanin. The tissue changes suggest an anomaly of catecholamine metabolism either endogenous or induced by a still unknown exogenous factor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00705533
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  • 8
    Digitale Medien
    Digitale Medien
    Myelin phagocytosis in Wallerian degeneration (1987)
    Springer
    Acta neuropathologica 75 (1987), S. 77-84 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Wallerian degeneration ; Myelin phagocytosis ; Macrophages ; Millipore diffusion chambers ; Immunocytochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Myelin phagocytosis in Wallerian degeneration was studied using a model of murine sciatic nerve degeneration in millipore diffusion chambers in the peritoneal cavity of host mice. Immunocytological investigations showed the dependence of myelin digestion on the invasion of Fc-positive, Mac-1-positive and partly Ia-positive monocytes. Lymphocytes did not play a prominent role. Compared to Wallerian degeneration in situ, phagocytosis was decreased in nerves enclosed by millipore membranes on both sides of the chamber. The membrane acted as a trap for invading monocytes/macrophages. Neither tissue integrity nor genetic strain influenced the degree of phagocytosis. A modification of the experimental technique is introduced which permits myelin phagocytosis in the peritoneal cavity in a degree comparable to that in Wallerian degeneration in situ.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00686796
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  • 9
    Digitale Medien
    Digitale Medien
    Dorsal root ganglia cocultured with macrophages: an in vitro model to study experimental demyelination (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 459-464 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Dorsal root ganglia ; Macrophages in vitro model ; Oxygen radicals ; Experimental demyelination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The present investigation introduces an in vitro model to study macrophage properties during demyelination. Rat dorsal root ganglia (DRG) were cultured for obtaining myelinated peripheral nerve fibers. These cultures were exposed to non-resident macrophages. In untreated control cultures, there was no indication of myelin removal by the added macrophages. DRG were exposed to enzymatically generated oxygen radicals using the xanthin/xanthin oxidase or the glucose/glucose oxidase system. Assessment of Schwann cell viability and ultrastructural morphology revealed different patterns of cell cytotoxicity and morphological changes in different experiments. High concentrations caused complete tissue necrosis of the DRG, while low concentrations did not affect either cell viability or ultrastructural morphology. Under intermediate experimental conditions, oxygen radicals caused non-lethal Schwann cell damage leading to Schwann cell retraction and myelin sheath rejection. Myelin lamellae were disrupted and decompacted. These changes were followed by a selective macrophage attack on myelin sheats, resulting in demyelination. Axons, Schwann cells and sensory ganglion cells survived this attack. The specificity of the oxygen radical effects was tested in experiments using the oxygen radical scavengers catalase and superoxide dismutase. Catalase prevented the described effects on cell morphology and subsequently blocked demyelination by non-resident macrophages.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00389499
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  • 10
    Digitale Medien
    Digitale Medien
    Dorsal root ganglia cocultured with macrophages: an in vitro model to study experimental demyelination (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 459-464 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Key words Dorsal root ganglia ; Macrophages ; In vitro model ; Oxygen radicals ; Experimental demyelination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The present investigation introduces an in vitro model to study macrophage properties during demyelination. Rat dorsal root ganglia (DRG) were cultured for obtaining myelinated peripheral nerve fibers. These cultures were exposed to non-resident macrophages. In untreated control cultures, there was no indication of myelin removal by the added macrophages. DRG were exposed to enzymatically generated oxygen radicals using the xanthin/xanthin oxidase or the glucose/glucose oxidase system. Assessment of Schwann cell viability and ultrastructural morphology revealed different patterns of cell cytotoxicity and morphological changes in different experiments. High concentrations caused complete tissue necrosis of the DRG, while low concentrations did not affect either cell viability or ultrastructural morphology. Under intermediate experimental conditions, oxygen radicals caused non-lethal Schwann cell damage leading to Schwann cell retraction and myelin sheath rejection. Myelin lamellae were disrupted and decompacted. These changes were followed by a selective macrophage attack on myelin sheaths, resulting in demyelination. Axons, Schwann cells and sensory ganglion cells survived this attack. The specificity of the oxygen radical effects was tested in experiments using the oxygen radical scavengers catalase and superoxide dismutase. Catalase prevented the described effects on cell morphology and subsequently blocked demyelination by non-resident macrophages.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00389499
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