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  • 1
    Digitale Medien
    Digitale Medien
    Theoretical Study of the Metacyclophanes anti-Benzo[9,10-a][2.2]metacyclophan-1-ene, trans-12c,12d-Dihydrobenzo[e]pyrene, and Benzo[e]pyrene (1994)
    s.l. : American Chemical Society
    The @journal of organic chemistry 59 (1994), S. 2135-2137 
    Details
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jo00087a034
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  • 2
    Digitale Medien
    Digitale Medien
    Growth Inhibition of Bacteria by Salsa Mexicana (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 68 (2003), S. 0 
    Details
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: : Antimicrobial activity of salsa mexicana against Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Saccharomyces cerevisiae was studied. The pressed salsa juice suppressed completely the growth of E. coli, B. subtilis, and S. aureus. K. pneumoniae and B. cereus were suppressed partly but Saccharomyces cerevisiae was not suppressed at all by the juice. Three types of microbicidal or microbiostatic components have been found: (1) H+, (2) volatile compounds, and (3) non-ionized carboxylic acids or analogous compounds. It is proposed that the supplementation of stink bugs in the salsa seen widely in the south of Mexico is used to intensify the herbal odor of the salsa.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.2003.tb06989.x
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  • 3
    Digitale Medien
    Digitale Medien
    Photocurrent determination of charge transport parameters in KNbO"3:Fe^3^+
    Amsterdam : Elsevier
    Optical Materials 3 (1994), S. 61-64 
    Details
    ISSN: 0925-3467
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Maschinenbau , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0925-3467(94)90030-2
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  • 4
    Digitale Medien
    Digitale Medien
    Optical properties of Eu^2^+, Eu^3^+ and Mn^2^+ in cubic perovskite crystals
    Amsterdam : Elsevier
    Journal of Luminescence 42 (1988), S. 35-42 
    Details
    ISSN: 0022-2313
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-2313(88)90063-4
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  • 5
    Digitale Medien
    Digitale Medien
    Effect of temperature and ionizing radiation on the Eu-Mn pair in NaCl
    Amsterdam : Elsevier
    Solid State Communications 57 (1986), S. 789-792 
    Details
    ISSN: 0038-1098
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0038-1098(86)90176-6
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  • 6
    Digitale Medien
    Digitale Medien
    Optimal timing of granulocyte colony-stimulating factor (G-CSF) administration after bone marrow transplantation (1995)
    Springer
    Annals of hematology 71 (1995), S. 65-70 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Allogeneic bone marrow transplantation ; Autologous bone marrow transplantation ; Granulocyte colony-stimulating factor (G-CSF) ; Hematopoietic recovery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  The positive role of G-CSF in hastening the myeloid recovery of patients undergoing allogeneic bone marrow transplantation (ALLO-BMT) or autologous bone marrow transplantation (ABMT) has recently been established. Considerable knowledge about adequate doses and route of administration has been accumulated in the past few years. Nonetheless, the optimal time to start growth-factor administration remains undetermined. We have performed a stratified study according to the source of hematopoietic progenitors (ALLO-BMT or ABMT), underlying disease and its stage, and acute graft-versus-host disease (GVHD) prophylaxis regimen and randomized patients in two arms: group A, which started G-CSF on day 0 (36 patients), and group B, which started on day +7 post-BMT (39 patients). The same dose (5 μg/kg/day) and route of administration were employed in both groups. We found no significant differences in the time to reach an absolute neutrophil count (ANC) of 0.1, 0.5, and 1×109/l and 50×109 platelets/l (medians: 10 and 11, 14.5 and 14, 17 and 16, 23 and 24 days, respectively, in groups A and B). We did not find differences in the days of fever or days on antibiotic treatment with less than 1×109/l ANC, rate of bacteriemia, or days of hospitalization in both groups. In contrast, a considerable saving of G-CSF in B group was found (mean days of infusion in group A, 18, versus 11 in group B) (p〈0.0001). This is equivalent to a saving of 1120 $US per patient. Therefore, early use of G-CSF after BMT is useless and more expensive and provides no advantage over delayed administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01699248
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  • 7
    Digitale Medien
    Digitale Medien
    Optimal timing of granulocyte colony-stimulating factor (G-CSF) administration after bone marrow transplantation (1995)
    Springer
    Annals of hematology 71 (1995), S. 65-70 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Allogeneic bone marrow transplantation ; Autologous bone marrow transplantation ; Granulocyte colony-stimulating factor (G-CSF) ; Hematopoietic recovery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The positive role of G-CSF in hastening the myeloid recovery of patients undergoing allogeneic bone marrow transplantation (ALLO-BMT) or autologous bone marrow transplantation (ABMT) has recently been established. Considerable knowledge about adequate doses and route of administration has been accumulated in the past few years. Nonetheless, the optimal time to start growth-factor administration remains undetermined. We have performed a stratified study according to the source of hematopoietic progenitors (ALLO-BMT or ABMT), underlying disease and its stage, and acute graft-versus-host disease (GVHD) prophylaxis regimen and randomized patients in two arms: group A, which started G-CSF on day 0 (36 patients), and group B, which started on day +7 post-BMT (39 patients). The same dose (5 Μg/kg/day) and route of administration were employed in both groups. We found no significant differences in the time to reach an absolute neutrophil count (ANC) of 0.1, 0.5, and 1×109/l and 50×109 platelets/l (medians: 10 and 11, 14.5 and 14, 17 and 16, 23 and 24 days, respectively, in groups A and B). We did not find differences in the days of fever or days on antibiotic treatment with less than 1×109/l ANC, rate of bacteriemia, or days of hospitalization in both groups. In contrast, a considerable saving of GCSF in B group was found (mean days of infusion in group A, 18, versus 11 in group B) (p〈0.0001). This is equivalent to a saving of 1120 $US per patient. Therefore, early use of G-CSF after BMT is useless and more expensive and provides no advantage over delayed administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01699248
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  • 8
    Digitale Medien
    Digitale Medien
    Spectral Criteria for Design of an Optical Modulator Based on Frustrated Total Internal Reflection (2000)
    Springer
    Optical review 7 (2000), S. 199-204 
    Details
    ISSN: 1349-9432
    Schlagwort(e): frustrated total internal reflection ; optical spectrum analysis ; optical modulators ; infrared spectroscopy ; spectrometers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The spectral study of an optical modulator based on the frustrated total internal reflection is presented under static and dynamic conditions. An optical modulator based on macroscopic moving parts makes spectrometers voluminous and has low compactness. The use of static or quasi-static optical modulators, such as the one proposed in this paper, avoids these problems. The study under static conditions reveals that the modulator equalises the spectral emittance of a black body. The modulation efficiency is defined by comparing the modulator with an ideal square chopper. Study under dynamic conditions reveals spectral criteria that must be met in the design of the mechanical system of the modulator to shift the maximum value of the modulation efficiency to the desired wavelength.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s10043-000-0199-2
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  • 9
    Digitale Medien
    Digitale Medien
    Population pharmacokinetics of imipramine in children (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 89-92 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Imipramine ; Paediatrics ; population pharmacokinetics ; enuresis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The population pharmacokinetics of imipramine (IMI) and its active metabolite desipramine (DMI) have been evaluated using 177 IMI and DMI serum levels from 49 enuretic children (6–13 y) on IMI treatment. Standard two stage (STS) and maximum likelihood (ML) methods were used to estimate fixed and random effect parameters of IMI. Simultaneous estimation of the drug and metabolite parameters was carried out by the STS method. The mean value of the elimination constant of the drug and metabolite were 0.0425 h−1 and 0.0359, h−1 respectively. Significantly higher variability was found in the pharmacokinetic parameters of the metabolite. According to these estimated pharmacokinetic parameters, the recommended dose for enuretic children should be 1.7 mg · kg−1 · day−. The population pharmacokinetic parameters obtained in the study permit dosage individualisation using a bayesian algorithm.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02280761
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  • 10
    Digitale Medien
    Digitale Medien
    Population pharmacokinetics of caffeine in premature neonates (1997)
    Springer
    European journal of clinical pharmacology 52 (1997), S. 211-217 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Key words Caffeine ; Apnoea of prematurity; neonato logy ; paediatrics ; population pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Objective: To determine population pharmacokinetic parameters of caffeine in premature neonates. Methods: This population analysis was done using 145 serum concentration measurements gathered from 75 hospitalized patients during their routine clinical care. The data were analysed by use of NONMEM (mixed effects modelling) according to a one-compartment open model with either zero or first-order absorption and first-order elimination. The effect of a variety of developmental, demographic and clinical factors (gender, birth weight, current weight, gestational age, postnatal age, postconceptional age and concurrent treatment with phenobarbital and parenteral nutrition) on clearance and volume of distribution was investigated. Forward selection and backward elimination regression identified significant covariates. Results: The final pharmacostatistical model with influential covariates were as follows: clearance (ml · h−1) =5.81 · current weight (kg) + 1.22 · postnatal age (weeks), multiplied by 0.757 if gestational age ≤ 28 weeks and 0.836 if the current primary source of patients' nutrition is parenteral nutrition, and volume of distribution (ml) = 911 · current weight (kg). The interindividual variability in clearance and the residual variability, expressed as coefficients of variation, were 14.87% and 18.44%, respectively. Due to the lack of information on the data set we were unable to characterize the interindividual variability for volume of distribution. Conclusion: In this study, which involved on average only two serum concentrations of caffeine per patient, the use of NONMEM gave us significant and consistent information about the pharmacokinetic profile of caffeine when compared with available bibliographic information. Additionally, parenteral nutrition and low gestational age (≤ 28 weeks) may even come to be considered as risk factors, and their presence may serve as an indicator of the need for periodic monitoring of caffeine concentrations in premature infants.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002280050276
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