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Acute ventilatory restriction in children after weaning off inhaled nitric oxide: relation to rebound pulmonary hypertension (1999)

Schulze-Neick, I. ; Werner, H. ; Penny, D. J. ; [weitere]

Springer

Intensive care medicine 25 (1999), S. 76-80

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Details

ISSN: 1432-1238

Schlagwort(e): Key words Nitric oxide ; Rebound ; Pulmonary hypertension ; Dynamic respiratory system compliance ; Interaction ; Congenital heart disease compliance ; Interaction ; Congenital heart disease

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Objective: To assess the interaction between pulmonary hemodynamics and respiratory mechanics during acute pulmonary hypertension. Patients: Ventilated and paralysed children treated with inhaled nitric oxide because of post-operative pulmonary hypertension. Interventions: Weaning of inhaled nitric oxide. Measurements: Air flow and airway pressure, calculation of dynamic respiratory system compliance and respiratory system resistance for each breath by multiple linear regression. Results: In four patients, increases in pulmonary arterial pressure from 26.1 to 56.7 mmg (p 〈 0.001) during weaning off nitric oxide were associated with decreases in tidal volume (from 9.7 → 8.2 ml/kg, p 〈 0.01) and reductions in dynamic respiratory system compliance (from 0.52 → 0.34 cmH20/ml/kg, p 〈 0.001), while respiratory system resistance was unchanged. Conclusions: Impaired ventilation during acute pulmonary hypertension is predominantly related to a reduction in respiratory system compliance.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s001340050790

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