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  • Artikel: DFG Deutsche Nationallizenzen  (16)
  • 1990-1994  (16)
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  • Artikel: DFG Deutsche Nationallizenzen  (16)
Materialart
Erscheinungszeitraum
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  • 1
    Digitale Medien
    Digitale Medien
    Contamination of heparin by histamine: measurement and characterization by high-performance liquid chromatography and radioimmunoassay (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 49 (1994), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Plasma samples which were collected in the presence of heparin contained 12.83 ± 0.34 ng/ml histamine-immunoreactive material (n= 10). In contrast, histamine-immunoreactive material in plasma samples which were collected in the presence of EDTA/phenanthroline contained 0.32 ± 0.01 ng/ml (n= 10). Histamine-immunoreactive material was found as a contaminant in three different heparin formulations with unrelated batch numbers. The concentrations of the histamine-like material were 32.82, 81.93, and 280.23 ng/ml, respectively. Octadecasilyl-silica (ODS) cartridges were used to purify histamine from other constituents in the heparin preparations. The histamine-immunoreactive material in the three preparations could be characterized as histamine with cation-exchange high-performance liquid chromatography (HPLC) on a TSK SP-5 PW column with NaH2PO4, pH5.0, as a mobile phase and gradient elution. For the accurate measurement of histamine in plasma samples with heparin as an anticoagulant, one should be aware of a possible contamination of heparin formulations by histamine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.1994.tb01131.x
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  • 2
    Digitale Medien
    Digitale Medien
    Manifestation of atopy is not related to patient's month of birth (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 48 (1993), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The first months of life may be an important period for allergic sensitization. Several studies suggest a relationship between the month of birth (MB) and the development of skin sensitivity to aeroallergens or the manifestation of an atopic disease. In 1988 and 1989 we investigated a population of 1066 Bavarian preschool children aged 5–6 years. Skin prick tests were performed with common aeroallergens (grass pollen, birch pollen, house-dust mite, eat epithelia). The personal history of atopic disease (atopic eczema, allergic rhinitis, bronchial asthma) was recorded by a questionnaire, and the presence of overt atopic disease was documented by a personal examination. Positive prick test reactions to the above-mentioned aeroallergens were found in 15.4%, 9.2%, 12.2%, and 10.4% of the subjects, respectively; lifetime prevalence of manifest atopic disease was 22.2% for atopic eczema, 11.7% for allergic rhinitis, and 4.5% for asthma. The MB distributions of children reacting to aeroallergens or of those with atopic diseases were compared with those of subjects with corresponding negative findings. Chi-square tests were performed for each aeroallergen and each of the atopic diseases separately. No significant differences among the MB distributions were found (P〉0.3). Thus, in this coherent group. MB correlated neither to allergic sensitization nor to manifest atopic disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.1993.tb00731.x
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  • 3
    Digitale Medien
    Digitale Medien
    Association of features of atopy and diagnostic parameters in hymenoptera venom allergy (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 46 (1991), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In a total of 525 patients with hypersensitivity reactions to hymenoptera stings diagnostic parameters of hymenoptera venom (HV) allergy (severity of reactions, skin test threshold and RAST for bee and vespid venoms) were investigated for their relationship to the following indicators of atopy: positive history of atopic diseases, elevated (≤ 100 kU/1) total scrum IgE and positive prick test reactions to common inhalant allergens (CIA) (grass pollen, cat epithelium, house dust mite). There was a conclusive history of atopic disease in 25%, a total serum IgE ≥ 100 kU/1 in 48%, and at least one positive reaction to CIA in 53%. Total IgE ≥ 100 kU/l correlated with a higher frequency of RAST classes ≥ 2 (P 〈 0.01) and with less severe reactions to hymenoptera stings (P 〈 0.05). In the presence of at least one positive reaction to CIA, there were more frequently skin test thresholds ≤ 10 μg/ml (P 〈 0.05) and RAST classes ≥ 2 (P 〈 0.01) for HV than in CIA prick test negative individuals. There was no significant relationship between the other pairs of parameters evaluated. Thus, reactivity to HV in diagnostic tests is increased in the presence of certain indicators of atopy. This has to be considered in the interpretation of skin test and RAST results obtained with HV.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.1991.tb00625.x
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  • 4
    Digitale Medien
    Digitale Medien
    H1- and H2-antagonists in allergic and pseudoallergic diseases (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Although known for more than 80 years, histamine still remains a fascinating substance for allergy research. Histamine antagonists have been in clinical use since 1942. The classical H1-antagonists with sedative side-effects have been more or less replaced by newer non-sedating H1-antagonists; the role of H2-receptors in allergic diseases is still controversial. There, are however, increasing reports of beneficial effects of H2-antagonists. mostly in combination with H1-antagonists, in a variety of allergic and pseudoallergic conditions such as chronic urticaria, anaphylactoid reactions due to colloid volume substitutes, opioid analgesics and radiographic contrast media. The combined use of H1- and H2-antagonists might not only act as specific histamine antagonism but exert a mast cell stabilizing effect, as demonstrated in animal experiments and some clinical studies. Future research will show whether the combined use of H1- and H2-anlagonists will become a routine therapeutic procedure in allergy therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb02460.x
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  • 5
    Digitale Medien
    Digitale Medien
    Hymenoptera venom anaphylaxis: may decreased levels of angiotensin peptides play a role? (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb03151.x
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  • 6
    Digitale Medien
    Digitale Medien
    The renin angiotensin system and hymenoptera venom anaphylaxis (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Components of the renin angiotensin system, namely renin, angiotensinogen, angiotensin I and II and aldosterone were measured in plasma of patients with hymenoptera venom anaphylaxis (n= 50) and healthy non-allergic controls (n= 25). Patients with a history of anaphylactic reactions to hymenoptera venom who did not undergo immunotherapy showed significantly reduced renin, angiotensinogen, angiotensin I and angiotensin II in plasma as compared with controls (P〈0.05). There was no difference in the aldosterone concentration between patients and controls. Angiotensin I, angiotensin II, renin and angiotensinogen levels were the same in male and female patients. There was also no difference in the angiotensin I, II, renin or angiotensinogen levels between young and older patients. A significant inverse correlation between the severity of clinical symptoms and the plasma levels of renin (r=-0.382, P〈0.001), angiotensinogen (r=-0.567, P〈0.0001), angiotensin I (r= -0.656, P〈0.0001) and angiotensin II (r = 0.0762, P 〈 0.0001) was found: the lower the levels the more severe the clinical symptoms. No correlation was found for aldosterone. Hymenoptera venom allergic patients with repeated anaphylactic reactions during hyposensitization did not tolerate the sting of a living insect (n= 6). In these patients, renin, angiotensinogen, angiotensin I and II remained significantly lower than in healthy non-allergic controls. Patients with successful immunotherapy (n= 27) who tolerated the sting of a living insect had renin, angiotensin I and II significantly higher than patients without immunotherapy. These findings suggest a possible role of the renin angiotensin system in hymenoptera venom anaphylaxis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb00364.x
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  • 7
    Digitale Medien
    Digitale Medien
    Urinary excretion of angiotensin I, II, arginine vasopressin and oxytocin in patients with anaphylactoid reactions (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Human urine samples, purified on octadecasilyl-silica cartridges, contained immunoreactive angiotensin I, II, arginine vasopressin and oxytocin. The daily excretion of these peptides in healthy volunteers was 190.00±38.43 (n=12), 17.48±3.09 (n=12), 63.43±14.84 (n=8) and 13.52±1.42 (n=7) pmol/24 hr, respectively (mean±s.e.m.). Patients with a history of anaphylactoid reactions to drugs or food additives showed clinical symptoms such as urticaria, flush, nausea, dizziness and hypotension after oral provocation with cyanocobalamine, propyphenazone, acetylsalicylic acid and sodium benzoate. In five of the seven patients, angiotensin I and II were increased several fold in the urine fractions after symptoms were reported. The average increase in the urine concentration of both peptides was fourfold and 5.5-fold. In three out of five patients, the mean excretion of arginine vasopressin and oxytocin immunoreactive material was also elevated by a factor of 5.7 and 4.4, respectively. Oral provocation with a placebo failed to elicit anaphylactoid symptoms or an increase in the urine levels of angiotensin I or angiotensin II. Angiotensin I and angiotensin II-like immunoreactivity could be characterized on HPLC as Ile5-angiotensin I, Ile5-angiotensin II and angiotensin II metabolites. HPLC characterization of immunoreactive arginine vasopressin and oxytocin in two different gradient systems showed retention times different than the retention times of the corresponding synthetic standard peptides indicating that both peptides are not authentic AVP and OXT. These results suggest that angiotensin I and angiotensin II may be involved in the clinical events observed during some forms of anaphylactoid reactions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb02830.x
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  • 8
    Digitale Medien
    Digitale Medien
    Histamine, antihistamines and atopic eczema (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Histamine is known to be a classical inducer of pruritus. In atopic eczema, itch is a prominent feature (regarded by some even as a‘primary lesion’!). One of the most potent chemical mediators of itch is histamine. Histamine, together with other mediators may play a role in the pathophysiology of atopic eczema: the increased release of histamine from basophil leucocytes of atopic patients has been described, as well as elevated histamine levels in plasma and skin during acute exacerbations of eczematous lesions. Therefore, application of H1 antagonists seems to be a rational regime in the symptomatic treatment of atopic eczema. Nevertheless, some controversy exists regarding the clinical efficacy of orally applied H1 antagonists in this disease, especially with regard to the newer non-sedating compounds such as terfenadine, astemizole, loratadine and cetirizine. Review of the literature shows that there are studies demonstrating a clear-cut antipruritic effect of non-sedating H1 antagonists. Thus the sedative action does not seem necessarily to be connected with therapeutic efficacy in treating itch in atopic eczema. Newer studies show that cetirizine exerts an additional inhibitory effect on eosinophils. This may broaden the therapeutic spectrum of this H1 antagonist in diseases with eosinophil involvement.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb02473.x
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  • 9
    Digitale Medien
    Digitale Medien
    Temperature Transients: A Model for Heat Diffusion through the Skin, Thermoreceptor Response and Thermal Sensation (1991)
    Oxford, UK : Munksgaard International Publishers
    Indoor air 1 (1991), S. 0 
    Details
    ISSN: 1600-0668
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Architektur, Bauingenieurwesen, Vermessung , Medizin
    Notizen: A model based on heat diffusion through the skin is developed for the dynamic response of cutaneous thermo-receptors to temperature stimuli at the skin surface. It is applied to various neurophysiological experiments with good results. The model is then extended to sensation and a set of psychophysical experiments on human subjects is examined and compared with the model predictions. Altogether, in terms of both the neurophysiological response and the sensation response, this model gives good agreement with the experiments.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0668.1991.00009.x
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  • 10
    Digitale Medien
    Digitale Medien
    Respiratory allergy and atopic eczema in a thatcher due to storage and house dust mite allergy (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 48 (1993), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.1993.tb00717.x
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