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  • 1
    Digitale Medien
    Digitale Medien
    Ultrastructural Evidence for Transport of Protein across the Epithelium of the Rat Caput Epididymidis (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 513 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb25099.x
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  • 2
    Digitale Medien
    Digitale Medien
    The Gap Junctional Protein Connexin(Cx)43 in Testicular Cancer: its Loss Marks Progession from Carcinoma In Situ to Invasive Germ Cell Tumour (2005)
    Berlin, Germany : Blackwell Verlag GmbH
    Anatomia, histologia, embryologia 34 (2005), S. 0 
    Details
    ISSN: 1439-0264
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Carcinoma-in-situ (CIS) of the testis is known to be the pre-invasive stage of most human germ cell tumours (seminoma and non-seminoma), but the mechanisms leading to an increased pubertal proliferation of CIS cells after a long latency and to progression of CIS to an invasive malignancy are still not known. Additionally, CIS and seminoma have also been reported in equine testis (Veeramachaneni and Sawyer, 1998). The gap junctional protein and tumour suppressor gene connexin(cx)43 represents the predominant cx in human, canine and rodent testis so far and it is expected to play a key role for the regulation of both proliferation and differentiation of germ cells (spermatogonia and spermatocytes), and its gene- and protein-expression pattern is typical for the pubertal terminal differentiation of somatic Sertoli cells. Using cDNA-microarray analysis, in-situ hybridization (ISH), RT-PCR from tissue homogenate and semi-quantitative RT-PCR from well defined microdissected tubules with normal spermatogenesis, CIS, intratubular seminoma (ISe) and from seminoma cells from invasive seminoma we found a downregulation of cx43 starting in intratubular CIS, leading to a complete loss in most invasive seminoma cells. This indicates that regulation of cx43 expression takes place at transcriptional level confirming and expanding earlier studies of protein expression (Brehm et al., 2002). This reduction of cx43-expression suggests that an early intratubular derangement in cx43-gene expression and disruption of inter-cellular communication between Sertoli cells and/or Sertoli cells and pre-invasive tumour cells via cx43-gap junctions may play a role in the proliferation of CIS cells and seminoma cells and in the progression phase of testicular seminoma development.References  Veeramachaneni, D. N., and H. R.Sawyer, 1998: Carcinoma in situ and seminoma in equine testis. APMIS 106, 183–185.Brehm R., A. Marks, R. Rey, S. Kliesch, M. Bergmann and K. Steger, 2002: Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma. J. Pathol. 197, 647–653.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1439-0264.2005.00669_16.x
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  • 3
    Digitale Medien
    Digitale Medien
    The Expression of Connexins during Growth and Development of Skeletal Elements in the Dog (2005)
    Berlin, Germany : Blackwell Verlag GmbH
    Anatomia, histologia, embryologia 34 (2005), S. 0 
    Details
    ISSN: 1439-0264
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Efficient and well-regulated intercellular communication is essential to organize the activities of the different cell populations involved during growth and concomitant structural maturation of the skeleton. For direct cell-cell communication gap junctions composed of connexins (Cx) are present. So far 21 Cx types have been identified in mammals, which differ in molecular permeability as well as tissue expression pattern. To characterize the Cx distribution in the developing canine skeleton, samples from humerus, scapula and lumbar vertebrae of Beagle dogs aged 1.5, 3, 4.5 months and 1.5 years were fixed in Bouin's solution, decalcified with 25% EDTA and embedded in paraffin wax. Using immunohistochemistry and in situ hybridization, the expression of Cx 26, 30, 31, 32, 43, and 45 was studied in bone tissue plus associated epiphyseal and growth plate cartilage. Of all bone cells, osteoblasts showed the largest Cx expression repertoire: they were positive for Cx 26, 30, 32 and 43. After transformation into bone lining cells Cx43 expression was lost while in osteocytes only Cx 26 and 32 was detected. A wide variety of Cx reactions was also found in osteoclasts: Cx 26, 30, 32, and 43. In contrast, chondrocytes showed a much more restricted Cx expression pattern. Positive reactions were only seen in hypertrophic chondrocytes of epiphyseal cartilage (Cx 26, 31, 32) and in the proliferative (Cx32) and hypertrophic zone (Cx 26 and 32) of growth plate cartilage. Additionally, Cx31 was strongly expressed in the cellular layer of the periosteum covering areas of intensive bone modelling in the puppies. Age- and microlocation-dependent variations in expression and/or staining intensity were also observed in the other Cx types. These results demonstrated that canine bone cells are capable of synthesizing a wide variety of Cx types during skeletal development, thus propagating different cellular signals via gap junctions in a differentially regulated and requirement orientated manner.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1439-0264.2005.00669_106.x
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  • 4
    Digitale Medien
    Digitale Medien
    Fraction of H-bonded segments of N-ethylpyrrolidone, oligomeric and polymeric vinylpyrrolidone adsorbed from CHCl3 on silica measured by IR spectrometry (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 372-380 
    Details
    ISSN: 1435-1536
    Schlagwort(e): Polymer adsorption ; IR spectrometry ; fraction of adhered segments ; silica
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Notizen: Abstract The adsorption of N-ethylpyrrolidone (NEP), oligomeric and polymeric vinylpyrrolidone (OVP, PVP) on silica (Aerosil 200) from CHCl3 solution is investigated by IR spectrometry. The influence of the annealing temperature of the silica on the adsorbed amount and on the fraction of adhered segments was studied. The dependences of the amount adsorbed on solution concentration result for NEP in a Langmuir isotherm for OVP and PVP in high affinity isotherms. The fraction of adhered H-bridged carbonyl groups determined by compensation procedures, the fraction of surface SiOH groups occupied and the multiple interaction quotientQ show different dependences on the amount adsorbed for the measured adsorptives, indicating different interactions of the monomeric segments with the surface groups. This behaviour is explained by comparing the amount adsorbed in saturation with monolayer capacities, surface concentration of SiOH groups and frequency shifts. A splitting of the band of the bound carbonyl groups in a double peak was observed with OVP and PVP, referring to an additional interaction of polymer segments neighboured to specifically bound segments.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01410383
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  • 5
    Digitale Medien
    Digitale Medien
    Microcalorimetric studies of the adsorption of N-ethylpyrrolidone, oligomeric and polymeric vinylpyrrolidone from CHCl3 on silica (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 381-387 
    Details
    ISSN: 1435-1536
    Schlagwort(e): polymer adsorption ; microcalorimetry ; enthalpy of adsorption ; fraction of adhered segments ; silica
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Notizen: Abstract Adsorption enthalpies of N-ethylpyrrolidone, oligomeric and polymeric vinylpyrrolidone from CHCl3 solution on silica interfaces (Aerosil 200) have been measured at 25 °C by microcalorimetry. The dependence on surface coverage has been examined using measured adsorption isotherms. Binding enthalpies are calculated with fractions of adhered segments obtained by IR spectrometry and wetting enthalpies received from calorimetry. Fractions of adhered segments are derived from the adsorption enthalpies assuming equal binding enthalpies of monomers and polymer segments and considering desorption enthalpies of the solvent depending on the surface area of the polymer segments. The resulting enthalpies are compared with literature values from other solvents and the incongruity of the fraction of adhered segments obtained by IR, ESR, NMR and microcalorimetry is explained.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01410384
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  • 6
    Digitale Medien
    Digitale Medien
    Tracer permeability of rat cortical blood vessels during regional hypothermia (1987)
    Springer
    Acta neuropathologica 73 (1987), S. 349-356 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Blood-brain barrier ; Cortex ; Lanthanum tracer ; Potassium ; Ion-selective micro-electrode
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Using lanthanum nitrate as a tracer, the permeability of rat cortical blood vessels was investigated during regional hypothermia of the cerebral cortex by electron microscopy. The concentration of K+ ions in the extracellular space of the cortex was determined using an ion-selective micro-electrode. Only at temperatures below about 7°C was an extravasation of tracer observed in a number of cortical capillaries and arterioles, where some of the tight junctions became widened and permeable. In a few cases penetration of the tracer into vacuoles of phagocytosing pericytes or macrophages was found. The extravasation of the tracer could mainly be observed in vessels on and below the cortical surface, less often in deeper cortical parts. At the same degree of hypothermia, the K+ concentration in the extracellular space increased, reaching a maximal value of ca. 6 mmol/l at a depth of about 200 μm. As could be shown in one previous experiment, the K+ concentration reached normal values again after rewarming to 37°C for 15 min, but an extravasation of the tracer was still observed. The role of the endothelial tight junctions and of the astrocytes together with the pericytes (or macrophages) is discussed regarding their importance for the effectiveness of the blood-brain barrier system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688258
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  • 7
    Digitale Medien
    Digitale Medien
    Zuschriften und vorläufige Mitteilungen (1925)
    Springer
    Naturwissenschaften 13 (1925), S. 799-802 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01558810
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  • 8
    Digitale Medien
    Digitale Medien
    Über den hochmolekularen Zustand der Proteine und die Synthese proteinähnlicher Piperazin-Abkömmlinge (1925)
    Springer
    Naturwissenschaften 13 (1925), S. 1045-1050 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01559279
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  • 9
    Digitale Medien
    Digitale Medien
    Besprechungen (1926)
    Springer
    Naturwissenschaften 14 (1926), S. 1000-1004 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01504655
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  • 10
    Digitale Medien
    Digitale Medien
    Über den Molekülbegriff in der Strukturchemie (1926)
    Springer
    Naturwissenschaften 14 (1926), S. 1224-1227 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01451779
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