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  • 1
    Electronic Resource
    Electronic Resource
    Zwei seltene primäre Lebertumoren beim Rehwild (1984)
    Springer
    European journal of wildlife research 30 (1984), S. 259-264 
    Details
    ISSN: 1439-0574
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary This report discusses two primary liver tumours which developed spontaneously and which have not been described in roe deer before. These were a Haemangioma cavernosum in a liver celladenom and a solitary, primary malignes Lymphom which is best classified as a B-cell Lymphom.
    Abstract: Résumé Il est rendu compte de deux cas, inconnus jusqu'alors, de tumeurs hépatiques primaires, apparues spontanément chez le Chevreuil. Is s'agit, en l'occurence, d'un Hémangiome caverneux dans un Adénome de cellules hépatiques de même que d'un Lymphome primaire de nature maligne qui doit plutôt être classé comme un Lymphome B-cellulaire.
    Notes: Zusammenfassung Es wird über zwei bisher beim Reh nicht beschriebene spontan entstandene primäre Lebertumoren berichtet. Dabei handelt es sich um ein Haemangioma cavernosum in einem Leberzelladenom sowie um ein solitäres, primär malignes Lymphom, das am ehesten als ein B-Zell-Lymphom zu klassifizieren ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02241412
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  • 2
    Electronic Resource
    Electronic Resource
    Concanavalin a binding and neuronal differentiation (1984)
    Springer
    Virchows Archiv 402 (1984), S. 297-306 
    Details
    ISSN: 1432-2307
    Keywords: Neuronal tumours ; Neuronal differentiation ; Lectin histochemistry ; Concanavalin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concanavalin A (Con A) acceptors have been demonstrated in large differentiated neurons in a previous paper. In order to elucidate the correlation between Con A binding in normal and neoplastic neurons and lectin binding dependence upon the differentiation grade, 26 tumours of the neuronal series were examined using formalin fixed and paraffin embedded biopsy specimen. The neoplasms included 3 gangliocytomas, 7 gangliogliomas, 1 central neuroblastoma, 11 medulloblastomas, 2 retinoblastomas, and 2 sympathicoblastomas. Well differentiated neurons in gangliocytomas and gangliogliomas expressed a high intracytoplasmic Con A acceptor density comparable to the feature in large non-neoplastic neurons. Less differentiated neurons and neuroblasts showed a weak perinuclear fine granular binding or an absolute lack of binding molecules, respectively. Our results suggest that in a variety of tumours, Concanavalin A receptor density in neurons depends upon the degree of differentiation of the cell. Well differentiated cells have a higher density than poorly differentiated neoplastic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695083
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  • 3
    Electronic Resource
    Electronic Resource
    J-chain-producing immunoblastic lymphoma in a case of Richter's syndrome (1982)
    Springer
    Virchows Archiv 396 (1982), S. 213-224 
    Details
    ISSN: 1432-2307
    Keywords: B-CLL ; B-immunoblastic lymphoma ; Richter's syndrome ; J chain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 66-year old male with Richter's syndrome died 52 month after diagnosis of chronic lymphocytic leukaemia (CLL). The clinical course was characterized by a marked IgM hypoglobulinaemia which paralleled a chronically relapsing Herpes simplex infection. Autopsy showed a large retroperitoneal and intraabdominal tumour mass and well defined supradiaphragmatic lymphomas. Histological examination revealed a composite tumour consisting of CLL B-cell type (B-CLL) and immunoblastic malignant lymphoma of B-cell type (B-IbL). The lymphocytes bear μ-chains on their surface and to a lesser extend within their cytoplasm, the obviously defective immunoblasts produce J chains exclusively. Flow cytophotometric data seem to indicate an identical diploid stem line of the two tumours. The majority of the cells are in G0/1 phase. The CLL rarely produces mitoses, however, the IbL has a mitotic rate of 7% and a considerable proportion (33%) of cells in the phase of DNA-synthesis. This is the fourth malignant lymphoma and the second immunoblastic lymphoma to be reported that produces J chain in the absence of immunoglobulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431242
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  • 4
    Electronic Resource
    Electronic Resource
    Lymphoepithelial carcinoma (Schmincke type) as a derivate of the tonsillar crypt epithelium (1984)
    Springer
    Virchows Archiv 405 (1984), S. 85-93 
    Details
    ISSN: 1432-2307
    Keywords: Lymphoepithelial carcinoma ; Peanut lectin ; Ulex europaeus lectin ; S-100 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten tumours of tonsillar or epipharyngeal localization showing the histological picture of “lymphoepithelial carcinoma” (Schmincke 1921) were examined immunohistochemically using Peanut lectin, Ulex europaeus lectin-I and an antiserum to S-100 protein. The findings suggest a close relationship of this type of carcinoma to the normal tonsillar crypt epithelium. The majority of tumour cells are UEA-I-positive and PNL-negative, as is the crypt epithelium, while oral mucosa is both PNL- and to a lesser extent UEA-I-reactive. Tumour areas expressing this pattern contain a large number of asteroid-shaped PNL-positive histiocytes and arachnoid-shaped histiocytes reacting with anti-S-100 protein; both cell types being probably identical and representing typical elements of the normal tonsillar crypt epithelium. Consequently, the WHO-term “nasopharyngeal carcinoma, undifferentiated type” seems to be inadequate for this type of tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00694927
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of peanut lectin binding sites on human brain tumors as determined by peroxidase-antiperoxidase technique in paraffin sections (1983)
    Springer
    Acta neuropathologica 61 (1983), S. 21-26 
    Details
    ISSN: 1432-0533
    Keywords: Peanut lectin (PNL) ; Human brain tumors ; Granular cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peroxidase-antiperoxidase (PAP) technique was selected for visualizing the binding of peanut lectin (PNL) to the most frequent human brain tumors. The randomly selected material included neoplasms of neuroectodermal and mesenchymal origin. We employed 1–5 μm sections of routinely processed and paraffin-embedded tissues. PNL receptors were detected to a variable extent on the cell surface of astrocytoma, glioblastoma multiforme, oligodendroglioma, ependymoma, meningotheliomatous meningeoma, and plexus papilloma. In gliomas an increase in malignancy seems to be associated with a decrease in PNL binding. Except for the plexus papillomas, neuraminidase pretreatment had neither a qualitative nor a quantitative influence on the binding behavior of PNL. Intracellular PNL receptors could be detected in “granular cells” and in the perinuclear region of malignant gliomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688382
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  • 6
    Electronic Resource
    Electronic Resource
    Lectin target cells in human central nervous system and the pituitary gland (1984)
    Springer
    Histochemistry and cell biology 80 (1984), S. 165-169 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Peanut lectin (PNL), Concanavalin A (Con A) and Ulex europaeus lectin I (Ulex) were chosen to map their binding sites in different regions of formalin fixed and paraffin embedded human central nervous system tissue and pituitary gland tissues. An extended PaP method was used for PNL and Ulex, whereas a direct peroxidase technique was employed for Con A. In astrocytes, the cytoplasm as well as the delicate processes were stained by PNL and Con A; the most conspicious binding of PNL was seen in the ependymal cells and on the surface of plexus epithelial cells; in the anterior part of the pituitary gland a selective population was PNL positive. Intracytoplasmic Con A acceptors could be demonstrated in neurons, in ependymal cells, and in plexus epithelial cells. Intracytoplasmic Con A receptors were finely granular in astrocytes, oligodendrocytes, and in some cells in the pituitary gland. Ulex binding was restricted to the vascular endothelial cells and a selective population of cells in the pituitary gland. Our results suggest that lectins may be good tools for the evaluation of their respective target cells in the central nervous system and in the pituitary gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00679992
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  • 7
    Electronic Resource
    Electronic Resource
    Lectin-binding spectra in the hyperplastic human tonsil (1984)
    Springer
    Histochemistry and cell biology 81 (1984), S. 551-560 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In order to determine the effect of routine fixation on the lectin affinity of tissue structures, we used unconjugated lectins and an indirect immunoalkaline-phosphatase method for frozen sections, and the peroxidase-anti-peroxidase method for paraffin-embedded, formalinfixed tissue sections. Fourteen hyperplastic human tonsils were used, and the results of the binding spectra of each lectin were compared. In general, the binding spectrum defected in the paraffin sections was part of the broader range of affinity obtained in the frozen sections. The lectin receptors on the cell surface were especially affected by formalin fixation. On the other hand, the paraffin sections, because of their superior morphology, showed a better localization of the cytoplasmic reaction product and discriminated the cell types more accurately. Thus, the two tissue preparations are rather complementary. In the tonsil peanut agglutinin (PNA) and periodic acid/Concanavalin A (PA/Con A) proved to be suitable tools for distinguishing exactly between the crypt and the surface epithelium. Ulex europaeus agglutinin I (UEA) is a reliable endothelial marker with a strong affinity to the crypt epithelium. In the frozen sections, PNA regularly stained follicular-centre cells on their cell surface. PNA, Helix pomatia agglutinin (HPA), soybean agglutinin (SBA) and Con A stained the histiocytic population, especially PNA which additionally stained an “asteroid” histiocyte. This cell probably corresponds to the antigen-presenting histiocyte of the T-system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00489534
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  • 8
    Electronic Resource
    Electronic Resource
    Significance of Europium anomalies in silicate melts and crystal-melt equilibria: a re-evaluation (1984)
    Springer
    Contributions to mineralogy and petrology 87 (1984), S. 242-250 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Although europium speciation in silicate melts partly reflects prevailing oxygen fugacities, melt composition and structure play the major role in determining Eu2+/ Eu3+ ratios and europium partitioning into mineral phases. Experimental evidence by different investigators on the magnitude of the compositional effect on Eu2+/Eu3+ provides consistent results only if account is taken of the oxygen buffer system employed in the experiments. The medium-dependent reduction of europium can be understood in terms of the preferential stabilization of Eu2+ by a strong aluminosilicate complex in the melt phase, and to a much lesser degree by metasilicate complexes. The stability of these complexes increases as the field strength of the associated cation species decreases. Hence Eu2+-aluminosilicate complexes are preferentially stabilized relative to trivalent lanthanides in melts of appropriate composition and their presence minimizes the enthalpy of the melt. The influence of these complexes is particularly pronounced in melts with a high feldspathic component and a strongly polymerized structure. Their petrogenetic influence is best documented through the behaviour of europium relative to the other lanthanides during “anhydrous” anatexis in high-grade metamorphic terrains and in the anomalous europium partition coefficients of phenocryst phases which formed during the crystallization of highly silicic magmas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373057
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  • 9
    Electronic Resource
    Electronic Resource
    Geochemical proximity indicators of massive sulphide mineralization in the Iberian Pyrite Belt and the East Pontic metallotect (1983)
    Springer
    Mineralium deposita 18 (1983), S. 387-398 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract A comparative lithogeochemical study of mainly surface rocks of the Iberian Pyrite Belt (volcanic-sedimentary sequence) and the East Pontic metallotect (volcanic island arc system with few intercalations of marine sediments) has been performed in order to find facies-independent proximity indicators of massive sulphide mineralizations. As, Sb, Tl, and Na seem to be the most promising indicator elements for primary hydrothermal exhalation and/or alteration haloes. The size of the alteration haloes largely depends on the permeability of the country rocks and is best defined by ratios such as As/Na, Sb/Na, and Tl/Na.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206487
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  • 10
    Electronic Resource
    Electronic Resource
    Book reviews (1980)
    Springer
    Mineralium deposita 15 (1980), S. 406-408 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202807
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