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  • theophylline  (2)
  • Analytical quality indicators  (1)
  • C4B  (1)
  • 1
    Digitale Medien
    Digitale Medien
    The disposition of inhaled lysine theophylline in volunteers (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 635-637 
    Details
    ISSN: 1432-1041
    Schlagwort(e): theophylline ; inhalation ; saliva-serum distribution ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Six healthy volunteers received an iv infusion of 317 mg lysine theophylline (equivalent to 197 mg anhydrous theophylline) in order to calculate theophylline clearance by standard methods. They subsequently received a 20 minute inhalation of nebulised lysine theophylline. Serum and salivary theophylline concentrations were measured and all saliva was collected for the first hour. From these concentrations estimates were made of the distribution of theophylline into the blood and saliva with 40% to 94% identified in the blood. Very high salivary concentrations were reached during the inhalation phase with saliva: serum concentration ratios of between 60 and 1600.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543500
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  • 2
    Digitale Medien
    Digitale Medien
    The relationship between theophylline clearance and age in adult life (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 29-34 
    Details
    ISSN: 1432-1041
    Schlagwort(e): theophylline ; asthma ; clearance ; age ; adults ; elderly ; normal subjects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline. Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age. Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561019
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  • 3
    Digitale Medien
    Digitale Medien
    Delivering quality for the measurement of immunosuppressive drugs: current performance and future needs (1999)
    Springer
    Accreditation and quality assurance 4 (1999), S. 427-430 
    Details
    ISSN: 1432-0517
    Schlagwort(e): Key words Drugs proficiency testing ; Analytical quality indicators ; Calibrator material ; Traceability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract  Whilst it is generally agreed that measurement of immunosuppressive drugs is of value as a guide to therapy, there are a number of problems associated with the analytical techniques available. Proficiency testing schemes enable laboratories to judge their performance for the measurement of these drugs with their peers. However, current schemes only compare accuracy within-methods to document performance. This paper summarizes current findings and points out the limitations of our own schemes, and the measures we intend to use to address these deficiencies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007690050402
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  • 4
    Digitale Medien
    Digitale Medien
    The relative roles of C4A and C4B in prevention of immune precipitation, solubilisation and immune adherence (1992)
    Springer
    Rheumatology international 12 (1992), S. 187-190 
    Details
    ISSN: 1437-160X
    Schlagwort(e): C4A ; C4B ; PIP ; SOL ; Immune adherence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum albumin (BSA) ICs, or with the prevention of immune precipitation of BSA or alkaline phosphatase ICs, nor with immune adherence assayed using thyroglobulin and BSA ICs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00302150
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