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  • 1
    Digitale Medien
    Digitale Medien
    Auer-rod positive myelocytic leukemia cells in diffusion chambers: Differentiation along the eosinophilic pathway (1982)
    Springer
    Annals of hematology 45 (1982), S. 323-328 
    Details
    ISSN: 1432-0584
    Schlagwort(e): AML blast cells ; Eosinophilic differentiation ; Diffusion chambers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Auer-rod positive acute myelocytic leukemia (AML) blasts from a 33-year-old patient were cultured in diffusion chambers (DC) in order to test their differentiation potential. The cells were labeled with anti-human granulocyte antiserum known to be negative for eosinophils, and evaluated using the unlabeled peroxidase-antiperoxidase (PAP) method. Parallel to a decline in the number of leukemic blasts there was an increase of up to 86% in the number of granulocytic cells belonging to the eosinophilic series. Auer-rod bodies were found in the eosinophilic cells even after 20 days in culture. Staining with anti-granulocyte antiserum failed to demonstrate positive cells at any time during DC culture. Based on the negative reaction with the anti-granulocytic antibodies already at an early stage of development evidence is provided for the existence of a progenitor cell exclusively committed to the eosinophilic pathway.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00319526
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Quantitation of globin mRNA in individual human erythroblasts by in situ hybridization (1981)
    Springer
    Annals of hematology 43 (1981), S. 79-83 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Erythropoiesis ; Aplastic anemia ; Globin mRNA ; In situ hybridization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In situ hybridization of globin mRNA was performed in four human bone marrows using a 3H-cDNA derived from rat globin messenger. Erythroblasts were classified according to nuclear area as well as to morphological appearance after Giemsa staining. Grains over individual erythroblasts and reticulocytes were counted by incident light microphotometry. Reticulocytes from phenyl hydrazine-treated rats served as internal standards in order to allow a comparison of different experiments. The preliminary results from one normal bone marrow, one of stress erythropoiesis and two of aplastic anemia revealed the major content of globin mRNA in the stages of basophilic erythroblasts or proerythroblasts. In all cases there was a tendency of decreasing globin mRNA content towards orthochromatic erythroblasts, and even more so, towards reticulocytes. The results show some differences between normal and diseased erythropoiesis which are under study on a larger scale now in order to ascertain their significance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320464
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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