ISSN:
1432-1041
Keywords:
Cephacetrile
;
ampicillin
;
urinary tract infections
;
renal function
;
multicentre trial
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The efficacy and tolerability of cephacetrile and ampicillin in the treatment of urinary tract infections have been compared in a between patient, single blind, multicentre controlled trial. 68 in-patients were treated with cephacetrile or ampicillin in doses of 1 to 4 g/day, according to their creatinine clearances, for an average of 10 days. The two drugs had similar therapeutic effects, i.e. they produced significant decreases in leucocyturia (p〈0.001) and urinary culture colony counts (p〈0.001). No side effects were observed. The direct Coombs' test remained negative in all patients, even in those with advanced renal failure. To determined whether renal function was affected by treatment, creatinine clearance, and cylindruria, erythrocyturia and proteinuria were assessed in 24 h urine samples, before and after drug administration. None of these parameters were altered, except for a decrease in cylindruria (p〈0.05) after cephacetrile. It was concluded that cephacetrile was as active as ampicillin in the treatment of urinary tract infections and that there was no evidence of nephrotoxicity in the doses employed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558201
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