ISSN:
1432-2277
Keywords:
Key words Tacrolimus
;
Azathioprine
;
Kidney transplantation
;
Dual vs triple therapy
;
Rejection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This open, multicenter, randomized, parallel-group study evaluated the efficacy and safety of tacrolimus-based dual and triple therapy regimens. For this 3-month study (with 12-month follow up), 491 adult renal transplant patients were randomized and received either dual therapy (tacrolimus/corticosteroids; 246 patients) or triple therapy (tacrolimus/corticosteroids/azathioprine; 245 patients). Patient survival rates at months 3 and 12 were 99.2 (dual) vs 99.6 % (triple) and 97.8 vs 98.7 %, respectively. Graft survival rates at months 3 and 12 were 94.1 (dual) vs 95.4 % (triple) and 92.8 vs 93.3 %, respectively. After 3 months, the incidences of treated acute rejection were 28.8 (dual) and 29.7 % (triple); and 7.6 (dual) and 5.4 % (triple) for corticosteroid-resistant acute rejections. Between months 4 and 12, three new first rejections were reported, (dual: 2, triple: 1). For leukopenia (1.3 vs 11.7 %; P 〈 0.001) and anemia (14.8 vs 23.0 %, P = 0.026), significantly higher incidences were reported in the triple therapy group. The incidence of de novo insulin-dependent diabetes was 5.6 (dual) and 4.0 % (triple) at month 3. In terms of efficacy, no difference between the treatment groups was observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001470050356
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