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  • 1
    Electronic Resource
    Electronic Resource
    Interaction of Fragrance Materials With 2-Hydroxypropyl-β-Cyclodextrin by Static and Dynamic Head-space Methods (1999)
    Dordrecht, The Netherlands : Blackwell Science Ltd
    International journal of cosmetic science 21 (1999), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The stability constants for the inclusion of fragrance materials with 2-hydroxypropyl-β-cyclodextrin (2HP-β-C yD) in aqueous solution have been determined by the static head-space method. The 1:1 stability constants obtained by this method were in reasonable agreement with the corresponding values in the literature. In addition, the release profiles of fragrance materials from 2HP-β-CyD aqueous solution were investigated using the dynamic head-space method. It was found that the suppression of the fragrance materials release was dependent on their stability constants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1467-2494.1999.203156.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Masseter muscle activity during the whole day in children and young adults (1999)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 26 (1999), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Changes in size and shape of the craniofacial skeleton during growth may be related to the masticatory muscle function in daily life. The purpose of this study was to measure the masseter muscle activity during the whole day in children and to investigate the differences between children and young adults. Fifteen children (7·8–13·0 years of age) and 30 young adults (20·3–34·7 years of age), who had acceptable occlusions without any remarkable skeletal discrepancy or temporomandibular disorder, were used as the subjects. In both children and young adults, most high-amplitude bursts of masseter muscle appeared mainly during mealtime, whereas a substantially larger number of low-amplitude ones were widely distributed throughout the whole day. The number and total duration of bursts of masseter muscle activity during the whole day was greater in children than in young adults, although significant differences were not found between the sexes. During daytime and sleep, both the number and total duration of bursts were greater in children. During mealtime, no significant differences in the number of bursts were found between children and young adults, however, the duration of bursts tended to be longer in children. It is concluded that the masseter muscle activity during the whole day is greater in children than in young adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.1999.00478.x
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of endothelial nitric oxide synthase in human eccrine clear cells (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), which has at least three isoJorms: endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation. Studies by the avidin-biotin immunocomplex method, revealed eNOS immunoreactivity exclusively in the human eccrine clear cells. No eNOS immunoreactivity was observed in the eccrine dark cells or myoepithelial cells. No staining of iNOS or bNOS was observed in the eccrine yland. These findings indicate that NO pUiys a physiological part in the production and/or excretion of sweat in the human skin eccritie gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.d01-1237.x
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  • 4
    Electronic Resource
    Electronic Resource
    Electrophoretic changes in olfactory system proteins in masu salmon during parr-smolt transformation (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 47 (1995), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Changes in cytosolic proteins of the olfactory system (olfactory epithelium, olfactory nerve and olfactory bulb) and the telencephalon of masu salmon Oncorhynchus masou were analysed by two-dimensional polyacrylamide gel electrophoresis during parr-smolt transformation; parr, pre-smolt and full-smolt stages. In the olfactory system, several protein spots appeared and disappeared in the course of smolting. One protein spot in particular with an estimated molecular weight of 27 kDa and isoelectric point of 5.6 (M27) disappeared in common with the olfactory system during smolting. The disappearance of M27 was also observed in the telencephalon. These proteins, which appeared and disappeared, may reflect the changes in olfactory function during smolting. Simultaneously, the present study confirmed a salmonid olfactory specific protein of 24 kDa (N24), which existed in the olfactory system but not in the telencephalon, as a single neutral protein spot in masu salmon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1995.tb06028.x
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  • 5
    Electronic Resource
    Electronic Resource
    Correlation among dominance status, metabolic rate and otolith size in masu salmon (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 52 (1998), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: In spatial competition between individuals, neither fish sex nor body mass affected dominance status in masu salmon Oncorhynchus masou . In contrast, resting metabolic rate (MR) was significantly correlated with dominance status, indicating that a high metabolic rate can increase the dominance rank of juvenile salmon. Whole animal growth rate was significantly correlated with MR, but not with initial body weight. This suggests that the body size of masu salmon is not a cause, but rather a consequence, of dominance status which is closely related to MR. The increment width between otolith daily rings was also significantly correlated with MR. Thus, the size of the Otolith may indicate the degree of MR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1998.tb00799.x
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  • 6
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of hepatocyte growth factor in human coronary atherectomy specimens: comparison with transforming growth factor beta isoforms (1997)
    Springer
    Virchows Archiv 430 (1997), S. 407-415 
    Details
    ISSN: 1432-2307
    Keywords: Key words Hepatocyte growth factor (HGF) ; Transforming growth factor beta (TGF-β) ; Directional coronary atherectomy (DCA) ; Coronary artery disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The expression and localization of hepatocyte growth factor/scatter factor (HGF/SF) were examined immunohistochemically in 59 human coronary artery lesions retrieved by directional coronary atherectomy and compared with the localization of transforming growth factor beta isoforms (TGF-β1, -β2, and -β3). In 21 of the 59 specimens (35.6%) HGF-like immunoreactivity (HGF-IR) was revealed. The HGF immunopositivity rate of 45% (14/31) in thrombotic tissue was significantly (P 〈 0.05) higher than the rates of 7.3% (4/55), 7.1% (3/42), and 0% (0/14) in fibrous tissue, neointimal hyperplasia and atheromatous gruel, respectively. Immunoreactivity for HGF was much weaker than that for TGF-β isoforms in these components except in thrombotic tissue. These cells exhibiting strong HGF-IR were inflammatory cells such as monocytes/macrophages in thrombotic tissue, in tissue lesions adjacent to a thrombus, and outside the capillary walls in a portion of the neovascularized lesions. Smooth muscle cells (SMCs) hardly demonstrated HGF-IR. In contrast, in control coronary arteries obtained at autopsy, the HGF-IR was strongly expressed in SMCs. These findings suggest that HGF produced by macrophages play a part in the process of coronary plaque formation attributable to thrombus in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050050
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  • 7
    Electronic Resource
    Electronic Resource
    Hepatocyte nuclear factor-1a gene and non-insulin-dependent diabetes mellitus in the Japanese population (1998)
    Springer
    Acta diabetologica 35 (1998), S. 150-153 
    Details
    ISSN: 1432-5233
    Keywords: Key words Non-insulin-dependent diabetes mellitus ; MODY ; Hepatocyte nuclear factor-1α ; Genetics ; Microsatellite polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently, hepatocyte nuclear factor-1α (HNF-1α, which is encoded by the TCF1 gene) mutations were reported in a subset of patients with maturity onset diabetes of the young (MODY3). We studied the contribution of TCF1 to genetic susceptibility to common non-insulin-dependent diabetes mellitus (type 2) in Japanese subjects by investigating allelic association with type 2 diabetes use of three markers. We also studied the frequency of the G191D mutation, the only mutation of TCF1 reported so far in late-onset type 2 diabetes. A total of 356 subjects were studied. There were no significant differences in allele frequency of the three markers between patients with type 2 diabetes and control subjects. A G191D mutation was not found in the subjects studied, giving a frequency of less than 0.4% in common type 2 diabetes. The lack of association of type 2 diabetes with three markers in and near TCF1 suggests that mutations in TCF1 derived from a limited number of founders are not a major cause of common type 2 diabetes even in the genetically homogeneous Japanese population. The data also indicate that the G191D mutation in TCF1 plays little, if any, role in susceptibility to common type 2 diabetes in the Japanese.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920050120
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  • 8
    Electronic Resource
    Electronic Resource
    Dynamic structure of glomerular capillary loop as revealed by an in vivo cryotechnique (1996)
    Springer
    Virchows Archiv 427 (1996), S. 519-527 
    Details
    ISSN: 1432-2307
    Keywords: Quick-freezing ; Glomerulus ; Basement membrane ; Freeze-substitution ; Deep-etching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Morphological studies using immersion or perfusion fixation methods do not reveal the ultrastructure of functioning kidneys with normal circulation. A simple apparatus was developed for freezing the kidneys in vivo without stopping the blood supply, and the ultrastructure of the glomerular capillary loops was examined under different haemodynamic conditions. Mouse kidneys were frozen under normal blood flow conditions; others were frozen in the same way after ligation of the abdominal aorta at a point caudal to the renal arteries. They were then processed for the freeze-substitution or deep-etching method. Good ultrastructural preservation was obtained within about 5 μm depth from the frozen tissue surface. Functioning glomeruli with normal blood flow possessed open capillary lumens, different shapes of foot processes and atypical basement membranes with low density. Moreover, heterogeneity in width between foot processes was identified on the replica membranes. Under the acute conditions used to increase blood supply into the kidneys, the spaces between the flat foot processes became more widely dilated and the basement membrane was seen to be three-layered. The ultrastructure of glomeruli in functioning kidneys has been demonstrated for the first time by this “in vivo cryotechnique”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199513
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  • 9
    Electronic Resource
    Electronic Resource
    Morphologic Analysis of Common Atrioventricular Valves in Patients with Right Atrial Isomerism (1997)
    Springer
    Pediatric cardiology 18 (1997), S. 107 -111 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Common atrioventricular value — Right atrial isomerism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The objective of the study was to examine the relation between the morphology of the common atrioventricular valve and regurgitation of the valve in patients with right atrial isomerism. We examined seven consecutive patients with documented right atrial isomerism who subsequently underwent postmortem examination during a 10-year period. The degree of regurgitation and the diameters of the common valve were evaluated via cineangiography, and the site of regurgitation was evaluated by echocardiography. The morphology of the common atrioventricular valve was assessed further at autopsy. Cineangiography revealed valve diameters ranging from 14.8 to 27.8 mm (mean 20.9 mm). Valvar regurgitation was revealed within 2 months of birth in all patients. Regurgitation abruptly worsened in three patients after placement of a Blalock–Taussig shunt or a central shunt and postintubation. Autopsies revealed that the common atrioventricular valve consisted of four leaflets in five patients, and three leaflets in two. The anterior leaflets were large and protruding in all patients, and the lateral leaflets were thickened in six. All patients had a mass consisting of the left lateral leaflets and chordae with direct attachment of the chordae to the ventricular muscle (the right lateral leaflet was attached to the ventricular muscle and immobile in one patient). The lateral leaflets clung to the ventricular wall and exhibited poor movement in six patients. Leaflets with poor mobility corresponded to the regurgitant valvar site as assessed by echocardiography in six patients; and the regurgitation in three patients with acute deterioration occurred at the valvar side with poor mobility. It is concluded that the common atrioventricular valve in patients with right atrial isomerism has morphologic characteristics that may be associated with valvar regurgitation and malignant potential for abrupt deterioration after replacement of systemic–pulmonary shunting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900126
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  • 10
    Electronic Resource
    Electronic Resource
    1:1 Complex of Octadecanoic Acid and 3-Pyridinecarboxamide (1998)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 1367-1369 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270197019227
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    Paper (German National Licenses)
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