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  • 1
    Unbekannt
    Understanding early adolescent self and identity : applications and interventions (2002)
    Albany : State University of New York Press
    SUNY series, studying the self  
    Details
    Schlagwort(e): Estime de soi chez l'adolescent. ; Identité chez l'adolescent. ; Identity (Psychology) in adolescence. ; Self-esteem in adolescence.
    Notizen: Understanding early adolescent self and identity: an introduction / Thomas M. Brinthaupt & Richard P. Lipka -- Part I: Conceptual issues -- Self and identity in early adolescence: the pains and gains of knowing who and what you are / Catrin Finkenauer, Rutger C.M.E. Engels, Wim Meeus, & Annerieke Oosterwegel -- Self-esteem as a multifaceted construct / Michael H. Kernis -- Part II: School and the sense of self -- On academic identity formation in middle school settings during early adolescence: a motivational-contextual perspective / Robert W. Roeser & Shun Lau -- The ecology of middle grades school and possible selves: theory, research, and action / Peggy Clements & Edward Seidman -- Part III: Peer relationships and behavioral problems -- Self, self-esteem, conflicts, and best friendships in early adolescence / Margarita Azmitia -- Stability and change in global self-esteem and self-related affect / Françoise Alsaker & Dan Olweus -- Influence of competence and alcohol use on self-esteem: latent growth curve models using longitudinal data / Lawrence M. Scheier & Gilbert J. Botvin -- Part IV: Early adolescent interventions -- Identity in early adolescence via social change activities: experience of the adolescent social action program / Lily Dow Velarde, Randall G. Starling, & Nina B. Wallerstein -- A place to call home: youth organizations in the lives of inner city adolescents / Nancy L. Deutsch & Barton J. Hirsch -- Esteem-enhancement interventions during early adolescence / David L. DuBois, Carol Burk-Braxton, & Heather D. Tevendale
    Seiten: x, 395 p.
    ISBN: 0-585-46373-5
    URL: http://www.netLibrary.com/urlapi.asp?action=summary&v=1&bookid=87629
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  • 2
    Digitale Medien
    Digitale Medien
    New improvements on the Kansas State University cryogenic electron beam ion source, a user facility for low energy, highly charged ions : The 8th international conference on ion sources (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 902-905 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: The Kansas State University cryogenic electron beam ion source supplies low energy ion beams to users of the Department of Energy user facility for highly charged ions. The ions escape the source with an initial energy between 1.6 and 5 kV per charge and are analyzed in a 90° dipole magnet located on the high voltage platform. When leaving the platform the ions can be accelerated by up to 160 kV per charge or can be decelerated to about 20% of their initial energy, covering 2.5 orders of magnitude. We are in the process of adding another order of magnitude to the range of available ion energies as a newly installed lens allows for deceleration down to a very few percent of the initial energy. In addition we present the current microbunching and chopping system which has been substantially improved over the past 2 yr. © 2000 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1150327
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  • 3
    Digitale Medien
    Digitale Medien
    Is Eradication of Helicobacter pylori With Colloidal Bismuth Subcitrate Quadruple Therapy Safe? (2001)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 6 (2001), S. 0 
    Details
    ISSN: 1523-5378
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: When standard triple therapy fails to eradicate Helicobacter pylori, quadruple ‘rescue’ therapy is often used which, in Europe, generally comprises colloidal bismuth subcitrate (CBS) based triple therapy and a proton pump inhibitor. Since hypochlorhydria could greatly increase absorption of the toxic bismuth ion from CBS, we investigated the bismuth status of patients receiving anti-H. pylori quadruple therapy.〈section xml:id="abs1-3"〉〈title type="main"〉Materials and Methods.In a prospective open label study 34 patients with nonulcer dyspepsia or peptic ulcer disease, who had failed to eradicate H. pylori with standard triple therapy, were subsequently treated with CBS, omeprazole, amoxycillin and metronidazole (BOAM). A further 35 patients received triple therapy for the eradication of H. pylori: CBS, amoxycillin and metronidazole (BAM) (n = 18); placebo bismuth, amoxycillin and metronidazole (AM) (n = 9); or omeprazole, amoxycillin and metronidazole (OAM) (n = 8). Whole blood bismuth levels were determined before and within 24 hours of completing treatment. Analysis of bismuth was by inductively coupled plasma mass spectrometry, and concentrations were compared between groups and with the Hillemand ‘alarm level’ for blood bismuth (50–100 µg/l).〈section xml:id="abs1-4"〉〈title type="main"〉Results.BOAM gave higher blood bismuth levels than BAM (difference in means 13.1, CI 6.0–20.2, p 〈 .001); three (8.8%) patients taking BOAM had concentrations within the Hillemand alarm level at 54.2, 64.7 and 91.8 µg/l. OAM and AM did not alter baseline blood bismuth levels.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions.Caution should be observed in prescribing CBS with gastric acid suppression, and alternative bismuth preparations should be considered.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1523-5378.2001.00022.x
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  • 4
    Digitale Medien
    Digitale Medien
    Simple biochemical markers to assess chronic wounds (2000)
    Oxford, UK : Blackwell Science Inc
    Wound repair and regeneration 8 (2000), S. 0 
    Details
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We investigated the potential for the biochemical analysis of chronic wound fluid to predict healing using simple and widely available analytes in an out-patient clinic setting. Wound fluid was collected from 12 patients attending a leg ulcer clinic and analyzed for a variety of analytes, including lactate, total protein, and albumin. Twelve weeks after collection the wound was assessed for healing (defined as complete healing or greater than 50% reduction in wound size). The median total protein (44.3 ± 8.8 g/l) and albumin (25.0 ± 2.3 g/l) concentrations in exudate collected from four healing wounds were significantly higher (p 〈 0.05) than in exudate from eight nonhealing wounds (median total protein 29.7 ± 7.6 g/l, median albumin 17.0 ± 4.3 g/l). No significant difference was observed for lactate. A second specimen of wound fluid was collected from four of the patients (three nonhealing and one healing). The protein analysis confirmed the pattern observed for the first collection: nonhealing wounds had total protein and albumin which remained low compared to healing wounds. No wound with an exudate albumin of less than 20 g/l healed. Both total protein and albumin are stable analytes which can be easily measured in any laboratory and may offer a simple biomarker of healing in chronic wounds.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1524-475x.2000.00264.x
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  • 5
    Digitale Medien
    Digitale Medien
    Evidence of oxidative stress in chronic venous ulcers (2003)
    Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 11 (2003), S. 0 
    Details
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p 〈 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176)
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x
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  • 6
    Digitale Medien
    Digitale Medien
    Clip Placement After Sonographically Guided Percutaneous Breast Biopsy (2003)
    Oxford, UK : Blackwell Science Inc
    The @breast journal 9 (2003), S. 0 
    Details
    ISSN: 1524-4741
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: A simple and inexpensive technique for deployment of a metallic marker at the site of an ultrasound guided core breast biopsy is described. An illustrative case in which this technique was employed to mark the location of three biopsied lesions is presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1524-4741.2003.09319.x
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  • 7
    Digitale Medien
    Digitale Medien
    Selective and Effective Bactericidal Activity of the Cobalt (II) Cation against Helicobacter pylori (2004)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 9 (2004), S. 0 
    Details
    ISSN: 1523-5378
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background.  Although the anti-Helicobacter pylori activity of bismuth is well established, the therapeutic potential of other metal ions against the organism is not known.Materials and Methods.  We measured the minimum inhibitory concentrations of a series of metal ions, including several cobalt (II) compounds against four type strains and seven clinical isolates of H. pylori using three standard broth culture media and a defined medium. Other intestinal bacteria were also investigated for specificity of action.Results.  Cobalt chloride had marked activity against H. pylori (minimum inhibitory concentration range was 0.03–1.0 mg/l). The effect was specific because other transition metals had no effect and other intestinal bacteria were not affected by cobalt chloride. Activity was attributable to free cobalt ions as ligands inhibited activity in proportion to their affinity for the ions. Inhibition of cobalt activity was also observed in the presence of nickel, in a dose dependent fashion. However, cobalt activity was not directed towards the nickel-dependent urease enzyme because its effect was similar in wild-type and urease negative mutant strains of H. pylori. Finally, the viability of H. pylori was reduced at the same rate with 2 mg/l cobalt as with 1 mg/l amoxicillin.Conclusions.  Cobalt competes for nickel in its acquisition by H. pylori, but mediates toxicity in a nonurease dependent fashion. As cobalt MIC is similar to some antibiotics and 10 to a hundred times lower than for bismuth, cobalt may represent an effective form of therapy for H. pylori infection.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1083-4389.2004.00264.x
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  • 8
    Digitale Medien
    Digitale Medien
    Development of the Cardiac Conduction System as Delineated by minK-lacZ (2003)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 14 (2003), S. 0 
    Details
    ISSN: 1540-8167
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Introduction: Due to the lack of good molecular markers, for decades the morphogenetic origin of the cardiac conduction system has been a matter of debate. More recently, the spatial expression of minK-lacZ in the adult mouse heart has been shown, for the larger part, to be coincident with the conduction tissues. Methods and Results: To trace the embryonic development of this system, we performed an analysis of the expression of this construct throughout early cardiac development. Expression was first seen at the eighth embryonic day. Subsequently, discrete rings were found at the sinuatrial, atrioventricular, interventricular, and ventriculoarterial junctions. With time, the expression became restricted to boundary regions of the heart, such as the hinges of the leaflets of the pulmonary and aortic valves, the atrioventricular rings, and the venous valves, as well as becoming incorporated into the definitive conduction tissues themselves. In the postnatal heart, the areas retaining minK-lacZ positivity outside of the definitive conduction tissues are known to be the site of origin of abnormal cardiac rhythms, suggesting that ectopic foci may derive from tissues that share a common developmental pathway with the definitive conduction system. Conclusion: Our findings suggest that the boundary regions between compartments, along with the atrioventricular conduction axis, share a common developmental pathway. (J Cardiovasc Electrophysiol, Vol. 14, pp. 383-391, April 2003)
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1540-8167.2003.02467.x
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  • 9
    Digitale Medien
    Digitale Medien
    Amyloid Peptide Aβ1-42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors (2000)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 75 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: We have recently reported evidence that a very high affinity interaction between the β-amyloid peptide Aβ1-42 and the α7 nicotinic acetylcholine receptor (α7nAChR) may be a precipitating event in the formation of amyloid plaques in Alzheimer's disease. In the present study, the kinetics for the binding of Aβ1-42 to α7nAChR and α4β2nAChR were determined using the subtype-selective nicotinic receptor ligands [3H]methyllycaconitine and [3H]cytisine. Synaptic membranes prepared from rat and guinea pig cerebral cortex and hippocampus were used as the source of receptors. Aβ1-42 bound to the α7nAChR with exceptionally high affinity, as indicated by Ki values of 4.1 and 5.0 pM for rat and guinea pig receptors, respectively. When compared with the α7nAChR, the affinity of Aβ1-42 for the α4β2nAChR was ∼5,000-fold lower, as indicated by corresponding Ki values of 30 and 23nM. The results of this study support the concept that an exceptionally high affinity interaction between Aβ1-42 and α7nAChR could serve as a precipitating factor in the formation of amyloid plaques and thereby contribute to the selective degeneration of cholinergic neurons that originate in the basal forebrain and project to the cortex and hippocampus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0751155.x
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  • 10
    Digitale Medien
    Digitale Medien
    Facilitating factors and barriers to the implementation of intensive home-based behavioural intervention for young children with autism (2002)
    Oxford, UK : Blackwell Science Ltd.
    Child 28 (2002), S. 0 
    Details
    ISSN: 1365-2214
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin , Psychologie
    Notizen: Background Although international interest in intensive home-based early behavioural intervention for children with autism is increasing, there is little or no published research on the experiences of families conducting these programmes.Methods One hundred and forty-one UK parents conducting Lovaas-style interventions with their young child with autism were asked to identify factors that acted as facilitative factors and barriers to the implementation of these programmes. Parents responded to written questions contained within a questionnaire survey, and their responses were subjected to a content analysis procedure.Results Several of the facilitative factors and barriers were found to be similar. For example, a supportive therapy team was the most frequently cited facilitative factor, and problems recruiting and maintaining a suitable team was the most frequently reported barrier. Other factors seemed to be more independent constructs. For example, an important barrier was the lack of time and personal energy, but plenty of time and energy was not cited as a facilitative factor.Conclusions The practical implications of these results for families and for services supporting families engaged in intensive early behavioural intervention are discussed. In addition, more general implications for the designers of behavioural intervention programmes are identified.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2214.2002.00251.x
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