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Digitale Medien

Effect of amiodarone on 3H-ouabain binding sites in human skeletal muscle (1990)

Nørgaard, A. ; Jensen, J. H. ; Andreasen, F.

Springer

European journal of clinical pharmacology 38 (1990), S. 397-399

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Details

ISSN: 1432-1041

Schlagwort(e): amiodarone ; hypothyroidism ; 3H-ouabain-binding ; Na,K-pump ; skeletal muscle ; myopathy

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Na,K-ATPase, or the Na,K-pump, is essential for the excitability and contractility of muscle tissue. Hypothyroidism in associated with a marked decrease in the Na,K-pump concentration in skeletal muscle and myocardium. In 7 patients on long-term amiodarone treatment there was a 36% reduction in the concentration of 3H-ouabain binding sites in skeletal muscle biopsies compared to 7 healthy subjects. This decrease during long-term amiodarone treatment may represent an equivalent reduction in the concentration of the functional Na,K-pump and it may be important in the adverse effect of amiodarone on muscle.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00315584

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