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Digitale Medien

Systemic lupus erythematosus with necrotizing vasculitis and upregulated expression of VLA-4 antigen (1995)

Takeuchi, T. ; Aoki, K. ; Koide, J. ; [weitere]

Springer

Clinical rheumatology 14 (1995), S. 370-374

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ISSN: 1434-9949

Schlagwort(e): VLA-4 Antigen ; Systemic Lups Erythematosus ; Necrotizing Vasculitis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We report on a patient (S.A.), with well-defind SLE who developed a perforation of the ileum due to pathologically confirmed necrotizing vasculitis. No anti-DNA antibody was detected at the ileal perforation, and the serum complement level was normal. These findings rais ethe alternative possibility of a cellmediated immune mechanism as a cause of necrotizing vaculitis. Upregulateed expression and function of VLA-4 antigen on peripheral blood T cells were oberved, suggesting that T cells with VLA-4 antigen may participate in the onset and/or perpetuation of vascular inflammation.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02208357

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