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  • 1
    Electronic Resource
    Electronic Resource
    Effect of decreased plasma colloid osmotic pressure on development of pulmonary edema in dogs (1981)
    Springer
    Surgery today 11 (1981), S. 203-208 
    Details
    ISSN: 1436-2813
    Keywords: pulmonary edema ; lung lymph flow ; plasma colloid osmotic pressure ; pulmonary vascular hydrostatic pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of decreased plasma colloid osmotic pressure on the development of pulmonary edema was studied in anesthetized dogs. Lung lymph flow was used as a sensitive and reliable indicator of fluid filtration rate in the lung. When plasma colloid osmotic pressure alone was reduced by slow infusion of saline, and hydrostatic pressure in the pulmonary vascular bed was maintained at normal level by exsanguination, lung lymph flow increased almost linearly with the reduction in colloid osmotic pressure, but was not increased more than five fold of the control, despite a reduction of 80% in the plasma colloid osmotic pressure. Furthermore, there was no evidence of fluid in the tracheal aspirations and no gross evidence of pulmonary edema. In contrast, both decrease in colloid osmotic pressure and increase in pulmonary capillary hydrostatic pressure produced a marked increase in lung lymph flow. This flow varied linearly with the level of the pulmonary artery wedge-plasma colloid osmotic pressure difference and approached twelve fold of the control, when the plasma colloid osmotic pressure was reduced by 73% and the pulmonary artery wedge pressure was elevated by 20 mmHg from the baseline. Our data indicate that decreased colloid osmotic pressure is not associated with the development of pulmonary edema, when there is no increase in pulmonary vascular hydrostatic pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468839
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship between postoperative hypoxemia and the operative site (1981)
    Springer
    Surgery today 11 (1981), S. 317-322 
    Details
    ISSN: 1436-2813
    Keywords: postoperative hypoxemia ; site of operation ; true shunt ; miliary atelectasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of the site of operation on postoperative hypoxemia was studied in 104 patients undergoing thoraco-abdominal, thoracic, upper abdominal, lower abdominal, extra-abdominal and non-thoracic operations. The degree of postoperative hypoxemia was the most extensive in patients undergoing thoraco-abdominal, moderate in thoracic and upper abdominal operations, and minimal in lower abdominal and other operations. On the other hand, the duration of hypoxemia also differed with the surgical procedures. Arterial oxygen tension returned to almost control values by the 3rd postoperative day in cases of lower abdominal and extremity operations and by the 7th postoperative day in those undergoing thoracic and upper abdominal surgery. Postoperative hypoxemia, however, remained throughout the fourteen day study period, in patients undergoing thoraco-abdominal operation. True shunt was measured in 27 patients with thoraco-abdominal, thoracic and upper abdominal operations. An increase in true shunt was evident postoperatively in the entire group of patients. The increase was significantly larger and longer lasting in cases of thoraco-abdominal incision than that in cases of thoracic and upper abdominal incision alone. Differences in postoperative true shunt between cases of thoracic and upper abdominal incisions were nil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468954
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  • 3
    Electronic Resource
    Electronic Resource
    Thymoma: Clinicopathologic features, therapy, and prognosis (1980)
    Springer
    Surgery today 10 (1980), S. 232-237 
    Details
    ISSN: 1436-2813
    Keywords: benign and malignant thymoma ; irradiation ; epithelial ; lymphocytic and lymphoepithelial cell types
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have treated 40 patients with thymoma. All the 18 with benign thymoma were treated with resection alone and none had a tumor recurrence or died from disease-related causes. Postoperative survival in this group ranged from 2 months to 14 years. Of the 22 patients with malignant thymoma, 2 underwent total resection, 10 partial resection and 10 were non-resectable. Fifteen of the 20 patients with non-resectable and partially excised thymomas were given radiotherapy. The cumulative 5- and 10-year survival rate of irradiation treated patients was 45.6%, and 34.4%, respectively. Of 6 non-irradiated patients, only one who underwent complete excision of tumors survived for more than 10 years, and 5 died within 3 years after treatment. Based on our findings we suggest that all patients with malignant thymoma, irrespective of the extent of surgical treatment, should be given postoperative irradiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468753
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  • 4
    Electronic Resource
    Electronic Resource
    Abnormalities in maximum flow volume curve and closing volume in patients with hepatic cirrhosis (1980)
    Springer
    Surgery today 10 (1980), S. 265-269 
    Details
    ISSN: 1436-2813
    Keywords: hepatic cirrhosis ; maximum flow volume curve ; closing volume ; small airway ; interstitial pulmonary edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pulmonary functions were measured in 53 patients with hepatic cirrhosis in whom there was no clinical or radiographic evidence of pulmonary involvement. Spirometric tests such as total lung capacity, vital capacity, functional residual capacity, residual volume and forced expiratory volume during one second were within normal ranges, in all subjects. Flow volume curve and closing volume tests, however, were abnormal in the majority. The maximal expiratory flow at 50 per cent of vital capacity was not altered but the maximal expiratory flow at 25 percent of vital capacity was decreased significantly in patients with hepatic cirrhosis. The closing volume in patients with hepatic cirrhosis was also significantly increased. The abnormalities in flow volume curve and closing volume curve were also demonstrated in non-smokers, and at any age, in cases of hepatic cirrhosis. These results suggested that the narrowing or closure in small airways may occur in patients with hepatic cirrhosis. These changes may be due to mechanical compression of small airways by interstitial edema which was induced by presence in the circulating blood of vasoactive substances and endotoxins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468786
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  • 5
    Electronic Resource
    Electronic Resource
    Multimodality therapy for small cell carcinoma of the lung —The role of surgical treatment (1989)
    Springer
    Surgery today 19 (1989), S. 699-707 
    Details
    ISSN: 1436-2813
    Keywords: localized small cell lung cancer ; multimodality therapy ; surgical resection ; preoperative chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reviewing the outcome of 70 cases of clinically localized small cell lung cancer (SCLC) treated with combined modality treatment, we attempted to define the role of resection in this disease. The survival rate for all cases was 37 per cent at 2 years and 23 per cent at 3 years with a median survival time (MST) of 14 months. For 25 resected cases the overall 5-year survival rate was 37 per cent with an MST of 26 months. According to clinical staging, 5-year survival was 64 per cent for stage I and 20 per cent for stage II. However, none of the stage III cases achieved long-term survival, of over 3 years. In 45 non-resected cases, the overall response rate was 84 per cent with a 44 per cent complete response. The overall survival rate was 27 per cent at 2 years and 14 per cent at 3 years with an MST of 11 months. The 20 cases who achieved complete response had an MST of 26 months with 51 per cent alive at 2 years and 19 per cent at 5 years. Thus, we consider that lung resection is definitely indicated in cases with stage I and probably stage II SCLC. For stage III, however, particularly in cases with N2 disease, resection seems to offer no special benefit in favor of survival compared to combination chemotherapy and radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471721
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  • 6
    Electronic Resource
    Electronic Resource
    An intrathoracic vagus nerve schwannoma invading the trachea (1993)
    Springer
    Surgery today 23 (1993), S. 1113-1115 
    Details
    ISSN: 1436-2813
    Keywords: intrathoracic vagus nerve ; schwannoma ; tracheal invasion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with a schwannoma of the intrathoracic vagus nerve is presented. The tumor invaded the trachea and caused dyspnea. It was successfully excised by a segmental resection of the trachea with end-to-end anastomosis. This instance of an intrathoracic vagus tumor invading the trachea is, as far as we know, the first reported in the world.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309105
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  • 7
    Electronic Resource
    Electronic Resource
    Phase II trial of combination chemotherapy with cisplatin, carboplatin and etoposide in stage IIIB and IV small-cell lung cancer (1998)
    Springer
    Cancer chemotherapy and pharmacology 41 (1998), S. 453-456 
    Details
    ISSN: 1432-0843
    Keywords: Key words Small-cell lung cancer ; Chemotherapy ; Cisplatin ; Carboplatin ; etoposide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: A phase II trial combining cisplatin, carboplatin and etoposide was conducted in previously untreated patients with stage IIIB and IV small-cell lung cancer, in an attempt to increase response rates and prolong survival. Methods: Previously untreated patients with small-cell lung cancer, with measurable disease, aged ≤ 72 years, performance status ≤ 2, and adequate hematologic, hepatic and renal function were enrolled in the study. They were treated with 80 mg/m2 cisplatin on day 1, 100 mg/m2 carboplatin on days 2, 3 and 8, and 50 mg/m2 etoposide on days 1, 2, 3 and 8. Results: A total of 46 patients (20 with stage IIIB and 26 with stage IV disease) were enrolled in the study. A total of 186 courses of chemotherapy were given, and the dose was reduced in 27 courses (15%). The chemotherapy was repeated for four or more courses in 30 patients. There were 10 complete responses and 32 partial responses, for a total response rate of 91% (95% confidence interval, 79% to 98%). The median survival time and 2-year survival rates were 18 months and 22% for stage IIIB disease, and 14 months and 15% for stage IV disease. Major side effects were hematologic: leukopenia, anemia, and thrombocytopenia of grade 3 or more occurred in 48%, 46%, and 43% of patients, respectively. Conclusions: The three-drug regimen of cisplatin, carboplatin and etoposide is feasible and active against small-cell lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050766
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  • 8
    Electronic Resource
    Electronic Resource
    Detection of group C adenovirus DNA in small-cell lung cancer with the nested polymerase chain reaction (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 377-382 
    Details
    ISSN: 1432-1335
    Keywords: Adenovirus ; Small-cell lung cancer ; Polymerase chain reaction ; In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Group C adenovirus is latent in human tissues and can malignantly transform cells. The purpose of this study was to investigate the association between this virus and lung cancer. We investigated latent adenoviral infection using the nested polymerase chain reaction and in situ hybridization in transbronchial biopsy specimens from patients with small-cell lung cancer and non-small-cell lung cancer. The polymerase chain reaction was performed on DNA extracts with two sets of primers directed at a 261-base-pair target sequence of the E1A region of the adenoviral genome. In situ hybridization was performed on histological sections using DNA representing the entire adenovirus type 5 genome. E1A target DNA was present in 11 (31%) of 35 cases of small-cell lung cancer but in none of the 40 cases of non-small-cell lung cancer (P〈0.01). Of the 11 cases found positive by PCR, 8 were positive for adenovirus DNA by in situ hybridization. Adenovirus was prominent in tumor cells in 5 of the 8 cases, and in normal epithelial cells in the 3 remaining cases. Adenovirus DNA was not detected by in situ hybridization in specimens in which E1A DNA was not detected by the polymerase chain reaction. Small-cell lung cancer has mutations or deletions in the p53 and retinoblastoma genes more frequently than are found in non-small-cell lung cancer. Therefore, we speculate that adenovirus infection might participate in the pathogenesis of SCLC by producing mutation in these genes, rather than by inhibiting the function of these proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240120
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  • 9
    Electronic Resource
    Electronic Resource
    Tuberculosis following liver transplantation: report of a case and review of the literature (1996)
    Springer
    Transplant international 9 (1996), S. 589-592 
    Details
    ISSN: 1432-2277
    Keywords: Tuberculosis, liver transplantation ; Liver transplantation, tuberculosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on a 44-year-old man who developed tuberculosis 4 months after liver transplantation. The diagnosis was confirmed using a polymerase chain reaction (PCR) technique in bronchial alveolar lavage (BAL) fluid, and the patient was successfully treated by reducing his immunosuppression and administering antituberculous drugs. The patient became afebrile 20 days after starting antituberculous therapy and remains well at home. A review of the literature revealed that tuberculosis after liver transplantation is a rare complication with a reported mortality rate of as high as 40%. The mortality is highest for patients who become symptomatic within 3 months after transplantation (83% vs 0%, P〈0.01; Fisher's exact test) and for those with an interval between the initial symptom and diagnosis of more than 2 weeks (71% vs 0%, P〈0.05). Early diagnosis is, therefore, essential for successful resolution of tuberculosis after liver transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335560
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  • 10
    Electronic Resource
    Electronic Resource
    Giant extrathoracic hematoma after thoracoplasty —A case report (1991)
    Springer
    Surgery today 21 (1991), S. 360-363 
    Details
    ISSN: 1436-2813
    Keywords: thoracoplasty ; extrathoracic hematoma ; giant hematoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A rare case of an extrathoracic giant hematoma developing after a thoracoplasty in a 67 year old man is presented herein. The patient underwent a right thoracoplasty without removal of plombage and a left thoracoplasty with removal of plombage for tuberculosis of the bilateral upper lobes 27 and 24 years prior to presentation, respectively. He presented to us in May, 1987, with a subscapular tumor which had been growing over the last 5 years. A giant tumor, measuring 23×17×12 cm and weighing 2585 g was successfully removed and the patient has since been well without any evidence of recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470962
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