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  • 1
    Digitale Medien
    Digitale Medien
    THE DESIGN OF CLINICAL TRIALS FOR NEW THERAPIES IN BLADDER CANCER. IS IT TIME FOR NEW STRATEGIES ? (1995)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of urology 2 (1995), S. 0 
    Details
    ISSN: 1442-2042
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1442-2042.1995.tb00484.x
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  • 2
    Digitale Medien
    Digitale Medien
    Treatment of advanced hormone-refractory prostate carcinoma with a combination of etoposide, pirarubicin and cisplatin (1994)
    Springer
    Cancer chemotherapy and pharmacology 35 (1994), S. 225-229 
    Details
    ISSN: 1432-0843
    Schlagwort(e): Key words Prostate cancer ; Hormone-refractory prostate carcinoma ; EAP regimen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  A total of 20 patients with hormone-refractory prostate carcinoma entered a pilot study of combination chemotherapy based on the EAP (etoposide, Adriamycin and cisplatin) regimen, in which Adriamycin was replaced by pirarubicin, a less cardiotoxic derivative of Adriamycin. The response was assessed by criteria modified from those of the National Prostatic Cancer Project: prostate-specific antigen was employed instead of acid phosphatase. Of 18 evaluable patients, 6 achieved a partial response, 5 had stable disease, and in 7 the disease had progressed during therapy; thus, the overall response rate was 33.3% [95% confidence interval (CI) 11.5–55.1%]. Significant pain alleviation and performance status improvement were obtained in 5 of 12 patients (41.7%; CI 13.8–69.6%) and 3 of 13 patients (23.1%; CI 0.2–46.0%), respectively. Although myelosuppression was moderate to severe, no chemotherapy-related deaths or bacteriologically documented sepsis occurred; nor was there any clinical cardiotoxicity. All the responding patients received maintenance chemotherapy with etoposide thereafter. At present, the median duration of response is 33 weeks (range: 23–91 weeks) and the median survival period for all patients is 42 weeks (range: 27+ –136 weeks), with 12 deaths. In spite of the small number of patients treated, these results suggest that this chemotherapy regimen is active in advanced hormone-refractory prostate carcinoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00686552
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  • 3
    Digitale Medien
    Digitale Medien
    Treatment of advanced hormone-refractory prostate carcinoma with a combination of etoposide, pirarubicin and cisplatin (1995)
    Springer
    Cancer chemotherapy and pharmacology 35 (1995), S. 225-229 
    Details
    ISSN: 1432-0843
    Schlagwort(e): Prostate cancer ; Hormone-refractory prostate carcinoma ; EAP regimen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A total of 20 patients with hormone-refractory prostate carcinoma entered a pilot study of combination chemotherapy based on the EAP (etoposide, Adriamycin and cisplatin) regimen, in which Adriamycin was replaced by pirarubicin, a less cardiotoxic derivative of Adriamycin. The response was assessed by criteria modified from those of the National Prostatic Cancer Project: prostate-specific antigen was employed instead of acid phosphatase. Of 18 evaluable patients, 6 achieved a partial response, 5 had stable disease, and in 7 the disease had progressed during therapy; thus, the overall response rate was 33.3% [95% confidence interval (CI) 11.5–55.1%]. Significant pain alleviation and performance status improvement were obtained in 5 of 12 patients (41.7%; CI 13.8–69.6%) and 3 of 13 patients (23.1%; CI 0.2–46.0%), respectively. Although myelosuppression was moderate to severe, no chemotherapy-related deaths or bacteriologically documented sepsis occurred; nor was there any clinical cardiotoxicity. All the responding patients received maintenance chemotherapy with etoposide thereafter. At present, the median duration of response is 33 weeks (range: 23–91 weeks) and the median survival period for all patients is 42 weeks (range: 27+ −136 weeks), with 12 deaths. In spite of the small number of patients treated, these results suggest that this chemotherapy regimen is active in advanced hormone-refractory prostate carcinoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00686552
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  • 4
    Digitale Medien
    Digitale Medien
    Sparfloxacin in the treatment of males with urethritis (1992)
    Springer
    European journal of clinical microbiology & infectious diseases 11 (1992), S. 660-660 
    Details
    ISSN: 1435-4373
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01961679
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  • 5
    Digitale Medien
    Digitale Medien
    Clinical superinfection in complicated urinary tract infections: Therapy with broad-spectrum beta-lactam antibiotics in urology (1985)
    Springer
    Infection 13 (1985), S. S96 
    Details
    ISSN: 1439-0973
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In kontrollierten Phase III-Studien werden derzeit in Japan neue, in der Entwicklung befindliche Antibiotika verglichen. Da auf eine möglichst weitgehende Übereinstimmung der demographischen Daten der Patienten, der Dosierung und Behandlungsdauer geachtet wurde, können die Ergebnisse der Studien zur Beurteilung der Eigenschaften der neuen Antibiotika herangezogen werden. Die meisten Patienten, bei denen klinische Superinfektionen auftreten, leiden an Krankheiten der Harnwege, auf die sich komplizierte Harnwegsinfektionen aufpfropfen. Die Beseitigung oder Besserung dieser Grundkrankheiten ist die Voraussetzung dafür, daß klinische Superinfektionen vermieden werden können. Unter den Mikroorganismen, die vorwiegend nach Behandlung mit Breitspektrum-Beta-Lactam-Antibiotika klinische Superinfektionen auslösen können, sind Enterokokken,Pseudomonas aeruginosa, Pseudomonas spp. und Pilze. Enterokokken finden sich häufig bei Patienten mit Mischinfektionen, sie sind durch Wechsel der Antibiotika leicht zu beseitigen.
    Notizen: Summary In Japan, new antibiotics under development are compared with conventional antibiotics in Phase III controlled studies. Since the patients' demographic data, dosage, treatment period, etc. are made as uniform as possible in these studies, the results obtained are suitable for evaluating the characteristics of the new antibiotics. Most patients developing clinical superinfections suffer from complicated urinary tract infections due to underlying diseases. In order to avoid clinical superinfections, clinicians have to try to eradicate or alleviate these underlying diseases. The predominant microorganisms that may cause clinical superinfections to develop following therapy with broad-spectrum beta-lactam antibiotics include enterococci,Pseudomonas aeruginosa, otherPseudomonas spp. and fungi. Enterococci may frequently be detected in patients with mixed infections and can easily be dealt with by changing the antibiotics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01644227
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  • 6
    Digitale Medien
    Digitale Medien
    The dipstick test in the diagnosis of UTI and the effect of pretreatment catheter exchange in catheter-associated UTI (1992)
    Springer
    Infection 20 (1992), S. S157 
    Details
    ISSN: 1439-0973
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Wir untersuchten den Nutzen des Eintauchteststreifens zur Ermittlung einer Leukozyturie und Bakteriurie für die Diagnosestellung einer Harnwegsinfektion (HWI). Der Esterase-Streifentest läßt sich schnell durchführen; damit kann die Leukozytenesterase sehr leicht im Urin festgestellt werden. Der Nitrit- Streifentest zur Ermittlung einer Bakteriurie korrelierte dagegen sehr schlecht mit den Ergebnissen der Urinkultur. Daraus ergibt sich, daß der Esterase-Teststreifen zur Ermittlung einer Leukozyturie im Gegensatz zum Nitrit-Streifentest bei der Diagnosestellung einer HWI nützlich ist. Katheter-bedingte HWI sind die am schwierigsten zu behandelnden Gruppen von HWI. Einer der Gründe dafür ist die Bildung von Biofilm auf der Katheteroberfläche. Wir untersuchten die Wirksamkeit des Katheterwechsels unmittelbar vor Therapiebeginn einer Katheter-bedingten HWI, wobei zur Therapie 300 oder 600 mg/Tag Levofloxacin, eines der neueren Chinolone, verwendet wurde. Wir konnten jedoch keinen Einfluß dieser Maßnahme auf die Medikamentenwirksamkeit nachweisen.
    Notizen: Summary We examined the value of the dipstick test for detecting pyuria and bacteriuria in the diagnosis of urinary tract infection (UTI). The dipstick esterase test could be quickly assessed and could easily detect leukocyte esterase in the urine. This was well correlated with the conventional sedimentation method. The dipstick nitrate reduction method for detecting bacteriuria, however, was not well correlated with the urine culture method. These findings suggested that the dipstick esterase test was a useful method for detecting pyuria in the diagnosis of UTI, but not the dipstick nitrate reduction method. Catheter-associated UTI is the most difficult category of UTI to treat and control. One of the reasons for this is the formation of biofilm around the indwelling catheter. We attempted to evaluate the effect of catheter exchange just before treatment of catheter-associated UTI with either 300 or 600 mg/day of levofloxacin, one of the newer quinolones. However, we are unable to find any apparent effect on the drug's efficacy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01704360
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  • 7
    Digitale Medien
    Digitale Medien
    Proposals regarding guidelines for the evaluation of new antibacterial drugs for the treatment of UTI in children (1994)
    Springer
    Infection 22 (1994), S. S8 
    Details
    ISSN: 1439-0973
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01716026
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  • 8
    Digitale Medien
    Digitale Medien
    Neutrophil function in hyperosmotic NaCl is preserved by phosphoenol pyruvate (1991)
    Springer
    Urological research 19 (1991), S. 223-227 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Hyperosmolarity ; NaCl ; Neutrophil ; Phosphoenol pyruvic acid ; ATP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Hyperosmolority in the urinary tract inhibits the host defense against bacterial infection. NaCl contributes most to osmolority in the renal medulla and urine. Therefore, we studied the effect of hyperosmolar NaCl on neutrophil function. When osmolarity was increased by NaCl, polymorphonuclear leukocytes (PMNL) became defective in phagocytosis, intracellular killing of bacteria, chemotactic activity, and superoxide production. This coincided with a decrease in the intracellular adenosine triphosphate (ATP) content of PMNL. Both the inhibition of superoxide production and the reduction in ATP content did not occur at 4°C. By increasing ATP content, phosphoenol pyruvic acid (PEP) protected against the decrease in superoxide production. These results suggest that leukocyte function is inhibited by high concentrations of NaCl due to the activation of the Na+−K+ pump. PEP, an ATP precursor, can protect PMNL against osmotic stress by raising the intracellular concentration of ATP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00305299
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  • 9
    Digitale Medien
    Digitale Medien
    Endotoxemia and bacteremia in patients following ultrasonic lithotripsy (1987)
    Springer
    Urological research 15 (1987), S. 45-47 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Endotoxemia ; Bacteremia ; Ultrasonic lithotripsy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The incidence of endotoxemia was studied in 17 patients who underwent ultrasonic lithotripsy (USL), and compared with the incidence in 11 patients who underwent transurethral resection (TUR) and in 8 patients who underwent other operations. Fourteen of 17 patients (82%) who underwent ultrasonic lithotripsy had endotoxemia. The incidence of endotoxemia after USL was significantly higher than that after TUR (9%) or after other operations (12.5%). Only 2 of the 17 patients (12%) who underwent USL had bacteremia. The organisms isolated were P. mirabilis and S. sanguis, respectively. Six of the 14 patients with endotoxemia after USL suffered high fever. These data suggest that endotoxemia is a factor which causes high fever after USL.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00256335
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  • 10
    Digitale Medien
    Digitale Medien
    Chlamydia trachomatis antigen can be detected in the urine sample of men with non-gonococcal urethritis (1991)
    Springer
    Urological research 19 (1991), S. 235-236 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Chlamydia trachomatis ; First portion of voided urine ; Non-gonococcal urethritis ; Enzymeamplified immunoassay
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We tested the first portion of voided urine (FVU) and urethral swab from 80 patients with nongonococcal urethritis (NGU) using a novel enzymeamplified immunoassay (IDEIA) for the detection of Chlamydia trachomatis antigen. Urine specimens were positive in all patients with positive urethral swabs (positive coincidence ratio, 100%) and in 6 of 54 patients with negative swabs (negative coincidence ratio, 88.9%). Our data suggest that FVU is suitable for the detection of Chlamydia trachomatis antigen using the IDEIA test in patients with NGU.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00305301
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