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  • 1
    Electronic Resource
    Electronic Resource
    Effects of Various Adjuvants and a Viral Infection on the Antibody Specificity Toward Native or Cryptic Epitopes of a Protein Antigen (2003)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 57 (2003), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An immunization protocol that induces antibodies (Abs) directed to cryptic epitopes of a protein antigen (Ag) reduces the efficacy of vaccines that ideally should induce Abs against native epitopes. We have shown earlier that viral infections concomitant with immunization against a protein tend to shift the Ab specificity toward cryptic epitopes and tend to induce the production of autoantibodies (autoAbs). Here, we show the effects of three adjuvants on the Ab specificity in the absence or presence of a viral infection (lactate dehydrogenase-elevating virus or LDV), with human growth hormone (hGH) being, as before, the protein Ag.Pathogen-free CBA/Ht and BALB/c mice were immunized with hGH in the presence of complete Freund's adjuvant (CFA), monophosphoryl lipid A (MPL) or alum, with the animals being either infected with LDV or not infected with LDV. Conventional and competition enzyme-linked immunosorbent assays (ELISAs) indicated that in noninfected mice, CFA induced higher titres of anti-hGH Ab than did MPL or alum, with the Ab being almost totally directed to cryptic hGH epitopes. Strikingly, CFA plus LDV infection in CBA/Ht mice shifted the specificity of the anti-hGH Ab toward native epitopes, whereas the virus decreased the Ab titre when MPL or alum was used. Our Western blot results showed that 70% of mice immunized with hGH in the presence of any adjuvant produced autoAbs against a variety of tissue Ags. The amount of autoAb and the concentration of Ab to hGH cryptic epitopes did correlate, suggesting a relationship between both kinds of Ab. Significant differences were observed in the various effects of adjuvants and the viral infection between the two mouse strains used in this work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2003.01208.x
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  • 2
    Electronic Resource
    Electronic Resource
    Changes of expression of mitochondrial proteins involved in energy transduction in rat brain during aging (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oxidative damage is the major responsible for mitochondrial dysfunction during aging and many neurodegenerative diseases with respiratory chain Complex I mostly affected. A down-regulation of the mitochondrial respiratory chain Complex-I subunits ND1 (mitochondrial encoded) in rat total cerebral cortex RNA and 39 kDa (nuclear encoded) in frontal cortex protein extracts was observed at 6, 12 and 28 months of age. However the 39 kDa subunit showed an age-related up-regulation in the parietal cortex and no changes in the cerebellum protein extracts. In frontal and parietal cortex protein extracts a significant reduction of subunit α (nuclear encoded) of FoF1-ATP synthase, with no changes in the cerebellum, were also observed. A similar impairment was found also for mitochondrial adenine nucleotide translocator ANT-1 in total rat cerebral cortex RNA. Any change of subunit synthesis might lead to neuronal dysfunction and increase of ROS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.85.s2.16_8.x
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  • 3
    Electronic Resource
    Electronic Resource
    Porous glass as an adsorbent in thin-layer chromatography
    Amsterdam : Elsevier
    Journal of Chromatography A 46 (1970), S. 125-129 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(00)83976-X
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  • 4
    Electronic Resource
    Electronic Resource
    Postpartum development of the mother-young relationship in goats
    Amsterdam : Elsevier
    Applied Animal Behaviour Science 42 (1994), S. 145-152 
    Details
    ISSN: 0168-1591
    Keywords: Goat ; Labelling ; Maternal behaviour
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0168-1591(94)90154-6
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  • 5
    Electronic Resource
    Electronic Resource
    Anatomical bases for the puncture and injection of the shoulder joint (1982)
    Springer
    Surgical and radiologic anatomy 4 (1982), S. 7-12 
    Details
    ISSN: 1279-8517
    Keywords: Shoulder ; Articular puncture ; Arthrography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé A partir de coupes sériées et de dissections les auteurs étudient les différentes techniques de ponctions et injections pratiquées au niveau de la région de l'épaule, articulations scapulo-humérale et acromio-claviculaire, bourse sous-deltoïdienne, tendons des muscles péri-articulaires et nerf sus-scapulaire.
    Notes: Summary Basing our study on serial cuts and dissections, we have analysed the various techniques for puncture and injection in the region of the shoulder, the scapulohumeral and acromioclavicular joints, the subdeltoid bursa, the peri-articular muscles and tendons and the suprascapular nerve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01811184
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  • 6
    Electronic Resource
    Electronic Resource
    Macroscopic study of the adult thymus (1987)
    Springer
    Surgical and radiologic anatomy 9 (1987), S. 51-62 
    Details
    ISSN: 1279-8517
    Keywords: Macroscopic anatomy of the thymus ; Anatomy of the parathyroid glands ; Thymic compartment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La dissection de 48 pièces cadavériques, confrontée à des données opératoires, permet de rappeler la forme, la taille et la situation de cette glande chez l'adulte. La constitution de la loge thymique puis les rapports du thymus avec, en particulier, les vaisseaux du médiastin supérieur et la base du cou sont étudiés. Les positions respectives des glandes parathyroïdes inférieures et du thymus avec l'incidence de cette topographie dans la chirurgie de ces glandes, sont précisées. La vascularisation artérielle de la glande, encore très riche chez l'adulte est en faveur d'un organe fonctionnel dont l'involution physiologique est lente.
    Notes: Summary The dissection of. 48 cadaveric specimens has been compared with operative findings for a review of the shape, size and site of this gland in the adult. The structure of the thymic compartment and the relations of the thymus, particularly with the vessels of the superior mediastinum and the base of the neck, were studied. The relative positions of the inferior parathyroid glands and the thymus were identified, with respect to the influence of this topography on the surgery of these glands. The arterial suply to the thymus, which is still very abundant in the adult, presupposes a functional organ whose physiologic involution is slow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02116854
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  • 7
    Electronic Resource
    Electronic Resource
    Les artères vertébrales (arteria vertebralis) Segments atlanto-axoïdien V3 et intracrânien V4-Collatérales (1980)
    Springer
    Surgical and radiologic anatomy 2 (1980), S. 229-242 
    Details
    ISSN: 1279-8517
    Keywords: artère vertébrale ; vascularisation encéphalique ; artères spinales ; articulation cranio-rachidienne ; fosse postérieure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Résumé Les caractères anatomiques du système constitué par les deux artères vertébrales, leur trajet extracrânien intimement lié au rachis cervical, leurs collatérales, les possibilités de suppléance ainsi offertes expliquent les particularités de la pathologie circulatoire vertébro-basilaire. L'efficacité du couple vertébral peut cependant être contrariée par l'inégalité des deux piliers vertébraux, voire par l'hypoplasie de l'un d'entre eux. L'importance des réseaux anastomotiques tient moins à leur potentiel fonctionnel physiologique qu'à leur intervention possible dans la limitation d'un processus de thrombose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01557988
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  • 8
    Electronic Resource
    Electronic Resource
    Electrocardiographic and behavioral effects ofl-DOPA in the guinea-pig (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 983-984 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Verabreicht manl-Dopa (1000 mg/kg per os) an Meerschweinchen, so kann dadurch das konditionierte Verhalten gehemmt werden, während das Spontanverhalten und die Motilität unverändert bleiben. Es sind keine Modifikationen des Elektrokardiogramms festzustellen, selbst dann nicht, wenn die 60fache mittlere therapeutische Tagesdosis gegeben wird.
    Notes: Conclusions The effects ofl-DOPA administered per os on conditioning, spontaneous behavior and the electrocardiogram of the guinea-pig are reported and compared.l-DOPA is able to inhibit the conditioned behavior in doses per os without any effect on spontaneous behavior or motility. Moreoverl-DOPA in doses up to 15 times higher than the average therapeutic daily dose pro kg used in man (TDD), does not alter the ECG of the guinea-pig. We did not observe ECG changes even after a total dose pro kg 60 times higher than TDD, which induced behavioral alterations in the 4 treated animals and one death. The present results may indicate psychotropic properties forl-DOPA and do confirm the low toxicity and cardiotoxicity of the drug, when supplied in a pure preparation of quality 12.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02114145
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  • 9
    Electronic Resource
    Electronic Resource
    Left subpancreatic transplexus exposure of the proximal abdominal aorta (1996)
    Springer
    Surgical and radiologic anatomy 18 (1996), S. 167-172 
    Details
    ISSN: 1279-8517
    Keywords: Celiac axis ; Superior mesenteric artery ; Celiac plexus ; Multiorgan procurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs rapportent leur expérience basée sur l'étude anatomique de la région coeliaque de Luschka et sur la pratique des prélèvements multiorganes en vue de transplantations. Ils précisent les limites et le contenu de la région coeliaque et en particulier: la position du tronc coeliaque par rapport au ligament arqué médian du diaphragme, les rapports respectifs des branches collatérales de l'aorte abdominale, la place occupée par le plexus coeliaque et sa situation par rapport à la v. rénale gauche. A partir de ces éléments, ils décrivent une voie d'abord originale, transplexique, des origines du tronc coeliaque et de l'artère mésentérique supérieure. Ils montrent l'importance de cette voie d'abord, aussi bien en chirurgie vasculaire digestive que lors des prélèvements multiorganes, en vue de transplantations.
    Notes: Summary The authors report their experience based on the anatomical study of the celiac region and on the practice of abdominal multiorgan removal for transplantation. They particularly concentrate on the limits and the content of the celiac region of Luschka and particularly: the position of the celiac axis in relation to the median arcuate ligament of the diaphragm, the relations of the collateral branches of the abdominal aorta, the place being taken by the celiac plexus and its situation in relation to the left renal v. From these elements, they describe an original transplexus surgical exposure of the origins of the celiac axis and of the superior mesenteric a. They show the importance of this approach in abdominal vascular surgery and during abdominal multiorgan removal in transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346122
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  • 10
    Electronic Resource
    Electronic Resource
    Le foramen diaphragmatique de la veine cave (1980)
    Springer
    Surgical and radiologic anatomy 2 (1980), S. 373-379 
    Details
    ISSN: 1279-8517
    Keywords: diaphragme ; veine cave inférieure ; nerf phrénique droit ; artères phréniques inférieures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Résumé A partir d'un travail réalisé d'après 66 dissections du diaphragme et 4 séries de coupes, les auteurs présentent une étude descriptive et topographique du foramen de la veine cave. Ils précisent la forme ovalaire de cet orifice, ses dimensions et la distance qui le sépare des parois du thorax. Ils montrent que le foramen diaphragmatique est réalisé par la superposition de deux plans fibreux et qu'il existe un véritable canal diaphragmatique de la veine cave. Les auteurs rappellent la proximité du foramen de la veine cave et du hiatus œsophagien. Ils étudient enfin la vascularisation des berges du foramen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01558628
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