ISSN:
1432-1076
Keywords:
Guillain-Barré syndrome
;
Anti-GM1 antibody
;
Anti-GM2 antibody
;
Campylobacter jejuni
;
HLA-B35
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We report a 4-year-old girl diagnosed as having Guillain-Barré syndrome after infection by Penner serotype 19 ofCampylobacter jejuni. The patient had the HLA-B35 antigen. Neurological examination revealed distal-dominant weakness and intact sensation. Serial electrophysiological studies indicated that the predominant process was axonal degeneration involving motor nerves. An enzyme-linked immunosorbent assay revealed the presence of high titres of serum IgM antibodies to gangliosides GM1 and GM2. The IgM auto-antibody titres decreased concurrently with the clinical course of the illness and no switching from IgM to IgG secretion took place.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01958981
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