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  • 1
    Digitale Medien
    Digitale Medien
    Ecto-ATPases and 5'-nucleotidases in the caveolae of smooth muscle. Enzyme-histochemical evidence may indicate a role for caveolae in neurotransmission.
    Amsterdam : Elsevier
    Cell Biology International 18 (1994), S. 875-880 
    Details
    ISSN: 1065-6995
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1006/cbir.1994.1124
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  • 2
    Digitale Medien
    Digitale Medien
    Cytochemical study of dehydrogenases in spermatozoa of older men
    Amsterdam : Elsevier
    Experimental Gerontology 7 (1972), S. 239-240 
    Details
    ISSN: 0531-5565
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0531-5565(72)90013-7
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  • 3
    Digitale Medien
    Digitale Medien
    Morphological evidence of lysosomal uptake of high-density lipoproteins by rat adrenocortical cells in vitro
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 44 (1986), S. 185-194 
    Details
    ISSN: 0303-7207
    Schlagwort(e): aldosterone ; colloidal gold labelling ; corticosterone ; non-specific esterase ; receptor-mediated endocytosis
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(86)90062-6
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  • 4
    Digitale Medien
    Digitale Medien
    Distribution of potassium in rat adrenal zones studied by electron probe X-ray microanalysis (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 485-487 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung An gefriergetrockneten Kryostatschnitten der Rattennebennierenrinde wurden anatomisch drei verschiedene Zonen im Hinblick auf die Kaliumablagerung untersucht und festgestellt, dass sich Kalium vor allem in der tiefen Region der Zona glomerulosa ablagert.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01926798
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  • 5
    Digitale Medien
    Digitale Medien
    Pathological and experimental investigations in a case of gigantism (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 167-174 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Pituitary adenoma ; Gigantism ; Electron microscopy ; Immunocytochemistry ; Cell culture
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A pituitary adenoma was transsphenoidally removed from a 4.5-year-old girl suffering from gigantism. Prior to the operation both the growth hormone (GH) and the prolactin (PRL) levels in the serum were elevated. By light microscopy the tumor appeared to be an acidophilic adenoma. Two distinct cell types, the densely granulated and the sparsely granulated cells, could be distinguished by electron microscopy. Double immunolabeling revealed the presence of GH alone in some densely granulated cells and PRL alone in some sparsely granulated cells, as well as GH and PRL co-localized in both of the morphologically distinguished cell types. Both cell types were identified in the monolayer and the suspension cultures by electron microscopy. GH and PRL concentrations in the culture media were measured by radioimmunoassay. The basal secretion of growth hormone was almost uniform during the 3-week cell culture period. GH and PRL release was significantly inhibited by bromocriptine. Our studies revealed a bimorphous and bihormonal mixed adenoma in childhood.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00227764
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  • 6
    Digitale Medien
    Digitale Medien
    Light- and electron-microscopic features of an endocrinologically active pituitary adenoma cultured in vitro (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 245-249 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Pituitary adenoma ; Cell culture ; Ultrastructure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A pituitary adenoma from an acromegalic female patient has been studied in cell cultures. Two populations of parenchymal cells, i.e., elongated shapes and big pale forms with irregular outlines, were distinguished light-microscopically. Ultrastructurally, three types of cells were found. Two of them contained secretory granules in varying numbers and sizes. Based on the proportion of the various cellular elements these cells were considered as counterparts of the elongated shapes being responsible for the GH secretion at different rates. The third cell type with very few secretory granules was identified with the big pale forms. Presumably, they could be exhausted GH-secreting cells. Besides fine structural characterisation, cultured cells of endocrinologically active human pituitary adenomas offer suitable models for studying some phases of exocytosis and membrane retrieval.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00691254
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  • 7
    Digitale Medien
    Digitale Medien
    Intracellular distribution of arylsulphatase activity in adrenal cortical cells of the rat (1973)
    Springer
    Histochemistry and cell biology 34 (1973), S. 271-274 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Arylsulphatase (B) activity has been demonstrated by means of an electronmicroscopic cytochemical method (substrate: p-nitrocatechol sulphate; capturing ion: barium, pH 5.5) in the lysosomes, in many Golgi elements, and occasionally in the endoplasmic reticulum of rat adrenal cortical cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00303444
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  • 8
    Digitale Medien
    Digitale Medien
    DNA synthesis in lactotrophs of primary rat anterior pituitary cell cultures (1985)
    Springer
    Histochemistry and cell biology 82 (1985), S. 497-500 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Prolactin immunostaining in combination with thymidine autoradiography was used to characterize changes in the DNA-synthesizing activity of lactotrophs in primary monolayer cultures of the rat anterior pituitary gland treated for 3 days with thyroliberin (TRH), somatostatin (SRIF) and bromocriptine (CB 154). The number of lactotrophs labelled with3H-thymidine within the total pool of labeled pituitary cells was used to estimate DNA synthesis in prolactin-producing cells. TRH (10 ng/ml) stimulated DNA synthesis in the whole population of cultured cells but not in lactotrophs. TRH only weakly counteracted the noticeable inhibitory effect of CB 154 (0.75 μM/l) on thymidine incorporation into lactotrophs. SRIF (20 ng/ml) inhibited DNA synthesis in lactotrophs to a lesser extent than CB 154. The combination of methods used in this paper may be useful for studying the selective effects of regulators on the proliferative activity of various pituitary cell types in vivo and in culture.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02450486
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  • 9
    Digitale Medien
    Digitale Medien
    Lysosomes in anterior pituitary corticotrophs of the rat (1983)
    Springer
    Histochemistry and cell biology 78 (1983), S. 231-239 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary E600 resistent non-specific esterase activity or acid phosphatase activity were localized in corticotrophic cells identified by postembedding immunocytochemistry (PAP or protein A-immunogold techniques). The lysosomal system of this cell type consists of dense bodies, of a population of small lysosomes mostly situated at the cell periphery in the vicinity of secretory granules as well as of tubular structures. These latter were located either in the central part of the cytoplasm and probably belonged to the Golgi apparatus or at the cell periphery, partly in the extensions. Small lysosomes occurred to be in continuity with enzyme-containing tubules. In a few structures lysosomal enzyme activity and ACTH immunoreactivity overlapped. Some autophagic vacuoles seemed to contain secretory granule matrix. It is suggested that the concept of crinophagy can be extended to the corticotrophs, though the lysosomal system may be involved in the specific function of this cell type by other mechanisms as well.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00489501
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  • 10
    Digitale Medien
    Digitale Medien
    Lysosomal enzyme activities in hypo- and hypersecretory anterior pituitary cells (1984)
    Springer
    Histochemistry and cell biology 81 (1984), S. 79-85 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The involvement of lysosomes in ACTH and prolactin secretion was studied. Lysosomes were visualized in the anterior pituitary by their non-specific esterase (gold thioacetic acid technique) or acid phosphatase (Gomori technique) activity. Corticotrophs and mammotrophs were identified by postembedding immunocytochemistry for their respective hormones. Corticotrophs were rendered hypersecretory by bilateral adrenalectomy (7 or 12 days prior to examination), hyposecretory by dexamethasone administration. Prolactin secretion was enhanced by 17-beta-estradiol, prolactin release was inhibited by bromoergocriptine administration. Long-term hypersecretion of ACTH was accompanied by the presence of numerous autophagic vacuoles often containing secretory granules in the corticotrophs. Lysosomal enzyme-containing tubules and small lysosomes were abundant in the cytoplasm near the cell membrane, among the mature secretory granules. Feed-back inhibition of ACTH release by dexamethasone resulted in the extension of enzyme-containing tubules, continuous with cisternae and small lysosomes anywhere in the cytoplasm and in the appearance of numerous crinophagic vacuoles. A higher frequency of tubular lysosomes was described at the periphery of mammotrophs stimulated by 17-beta-estradiol. Bromoergocriptine caused a high incidence of characteristic crinophagic vacuoles in the prolactin cells. The concept of crinophagy has been extended to the corticotrophs. Morphological phenomena were attributed to the traffic and increased turnover of membranes, ligands and cytoplasmic organelles during stimulated secretion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00495405
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