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  • 1
    Digitale Medien
    Digitale Medien
    Properties of the partially purified activated glucocorticoid receptor of rat liver. Binding to chromatin subunits (1977)
    s.l. : American Chemical Society
    Biochemistry 16 (1977), S. 4694-4703 
    Details
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/bi00640a025
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  • 2
    Digitale Medien
    Digitale Medien
    Mytilus edulis Histone Gene Clusters Containing Only H1 Genes (1999)
    Springer
    Journal of molecular evolution 49 (1999), S. 645-655 
    Details
    ISSN: 1432-1432
    Schlagwort(e): Key words:Mytilus edulis— H1 histone genes — Gene organization — Nucleotide sequence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract. We isolated five different phage clones containing histone gene clusters with up to five H1 genes per phage clone from a Mytilus edulis genomic library. Among these H1 genes, nine gene types coding for five different H1 proteins have been identified. All H1 histone genes were located on repetitive restriction fragments with only slightly different sizes. The H1 coding regions show highly related sequences, suggesting that the multitude of H1 genes has evolved by gene duplication events. Core histone genes could not be found on these five Mytilus edulis genome fragments.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00006585
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  • 3
    Digitale Medien
    Digitale Medien
    Expression of the mouse testicular histone gene H1t during spermatogenesis (1996)
    Springer
    Histochemistry and cell biology 106 (1996), S. 247-251 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract  The testicular H1 histone variant, H1t, is synthesized during spermatogenesis in mammalian male germ cells. In situ hybridization and immunohistochemical techniques were used to assign the expression of either the H1t mRNA or the H1t protein to specific cell stages of spermatogenesis. Our results show the presence of the H1t mRNA only in the late and mid-pachytene stages, whereas the protein occurs first in pachytene spermatocytes, and persists until later stages from round up to elongated spermatids.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004180050039
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  • 4
    Digitale Medien
    Digitale Medien
    Spermatogenesis proceeds normally in mice without linker histone H1t (2000)
    Springer
    Histochemistry and cell biology 113 (2000), S. 433-442 
    Details
    ISSN: 1432-119X
    Schlagwort(e): Chromatin structure Linker histones H1t-deficient mice Spermatogenesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract. The histone gene H1t is expressed exclusively in pachytene spermatocytes of the testis. In this report we have eliminated the single copy H1t gene by homologous recombination from the mouse genome to analyse the function of the H1t protein during spermatogenesis. Mice homozygous for the mutated H1t gene locus developed normally and showed no anatomic abnormalities until the adult stage. In addition, H1t-deficient mice were fertile and reproduced as wild-type mice. The process of spermatogenesis and the testicular morphology remained unchanged in the absence of H1t. RNase protection analysis demonstrated that H1.1, H1.2 and H1.4 histone gene expression is enhanced during spermatogenesis in H1t-deficient mice.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004180000146
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  • 5
    Digitale Medien
    Digitale Medien
    A solitary human H3 histone gene on chromosome 1 (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 486-491 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract A solitary histone H3 gene encoding a novel H3 protein sequence has been isolated. This H3 gene maps to chromosome 1 (1g42), whereas we have shown previously that the majority of the human histone genes form a large cluster on chromosome 6 (6p21.3). In addition, a small cluster has been described at 1q21. The clustered histone genes are expressed during the S-phase of the cell cycle, hence their definition as replication-dependent histone genes. In contrast, expression of replacement histone genes is essentially cell-cycle independent; they are solitary genes and map outside the major clusters. The newly described H3 gene maps outside all known histone gene clusters and varies by four amino acid residues from the consensus mammalian H3 structure. In contrast to other solitary histone genes, this human H3 gene shows the consensus promoter and 3′ flanking portions that are typical for replication-dependent genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02267072
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  • 6
    Digitale Medien
    Digitale Medien
    Effects of antineoplastic phospholipids on parameters of cell differentiation in U937 cells (1990)
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 459-466 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Antineoplastic phospholipids ; U937 cells ; cell differentiation ; histone H10
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The proliferation of the human promonocytic leukemia cell line U937 is inhibited by several ether lipids, ether lipid analogues and by phorbol esters. An early effect of this retardation of cell growth is the induction of a basic chromosomal protein, histone H10. Northern blot analysis of H10 mRNA levels reveals an increase of the mRNA concentration within a few hours after addition of hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. This early effect on the synthesis of a subtype of H1 proteins precedes the expression of several parameters of the monocytic differentiation of U937 cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01612994
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  • 7
    Digitale Medien
    Digitale Medien
    Expression of the mouse histone gene H1t begins at premeiotic stages of spermatogenesis (1997)
    Springer
    Cell & tissue research 291 (1997), S. 127-132 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Key words Histone H1t ; Spermatogenesis ; Immunogold staining ; In situ hybridization ; Western blot analysis ; Mouse (NMRI)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract  The gene encoding H1t, a testicular variant of histone H1, is expressed in mammals during spermatogenesis. Northern blot and in situ hybridization has detected H1t mRNA only at the stage of pachytene spermatocytes. We have extended this analysis to more sensitive approaches and demonstrate, by RNase protection and electron-microscopic in situ hybridization, that H1t mRNA is detectable even in spermatogonia. Just a faint H1t band is seen in Western blots of nuclear protein from 9-day-old mice. This indicates that the H1t gene is expressed at premeiotic stages, albeit at a low level. In contrast to H1t mRNA, the H1t protein has not been detected in spermatogonia by electron microscopy after immunogold staining.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004410050986
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  • 8
    Digitale Medien
    Digitale Medien
    Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones (1993)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 52 (1993), S. 375-383 
    Details
    ISSN: 0730-2312
    Schlagwort(e): histone H1 ; histone H2A ; histone H2B ; histone H3 ; histone genes ; histone pseudogene ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: A cluster of human histone genes was found on three overlapping clones isolated from cosmid and bacteriophage libraries. These three overlapping segments of the human genome comprise genes coding for H3.1, an H2A pseudogene, and an H2B.1 gene downstream of the previously characterized H1.2 gene. The cosmid clone covers 30 kb upstream of the H1.2 gene and overlaps with two phage clones covering the core histone genes and the pseudogene. The same arrangement of an H3 gene, an H2A pseudogene and an H2B gene downstream of an H1 gene has been described within a mouse histone gene cluster [Yang et al.: J Biol Chem 262:17118-17125, 1987; Gruber et al.: Gene 95:303-304, 1990].
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcb.240520402
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  • 9
    Digitale Medien
    Digitale Medien
    The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene clusterSequence data reported in this article have been deposited with the EMBL/GenBank Data Libraries under Accession nos. Z92910 and Y12650. (1998)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 69 (1998), S. 117-126 
    Details
    ISSN: 0730-2312
    Schlagwort(e): haemochromatosis gene ; histone gene cluster ; YACs ; cosmid contig ; sequences ; species comparison ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: The HFE (HLA-H) gene is a strong candidate gene for hereditary haemochromatosis and was localized on the short arm of chromosome 6 to 6p21.3-p22. In addition, the sequence of the homologous mouse and rat cDNA and a partial sequence from the mouse gene have been reported recently. In this report, we describe the location of the human and the mouse HFE (HLA-H) gene within the histone gene clusters on the human chromosome 6 and the mouse chromosome 13. Both the human and the murine gene were located on syntenic regions within the histone gene clusters in the vicinity of the histone H1t gene. The genomic sequence of the human HFE (HLA-H) gene and the 3′ portion of the homologous mouse gene were determined. Comparison of the genomic sequences from man and mouse and the cDNA sequence from rat shows significant similarities, also beyond the transcribed region of the mouse gene. J. Cell. Biochem. 69:117-126, 1998. © 1998 Wiley-Liss, Inc.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
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