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  • 1
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Rhabdomyosarkom ; Fibrosarkom ; Immunhistochemie ; Key words Rhabdomyosarcoma ; Fibrosarcoma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report a case of an intrathoracic, extrapleural, infantile rhabdomyofibrosarcoma in a 4-year-old boy. Histologically, the primary lesion showed extensive hyalinization and stroma sclerosis and was composed of relatively uniform spindle-shaped, at least focally rather polygonal tumour cells with scattered intracytoplasmatic globoid inclusions. Although chemo- and radiotherapy was given postoperatively, local recurrences and metastases in the lung and thymus have developed; the patient died of tumour disease 3 years later. Recurrences and metastases showed features of tumour progression with higher cellularity and increased mitotic activity. Immunohistochemically, the tumour cells stained strongly positive for vimentin, desmin, and muscle-specific actin, and at least focally for MyoD1; the tumour did not stain for alpha-smooth muscle actin, neural and epithelial markers, or CD34 and CD31. The differential diagnosis of these aggressive tumours in the spectrum of spindle-cell lesions in early childhood is discussed.
    Notes: Zusammenfassung Wir referieren den Fall eines intrathorakalen, extrapleuralen, infantilen Rhabdomyofibrosarkomes bei einem 4jährigen männlichen Patienten. Der Primärtumor wies histologisch eine deutliche Hyalinisierung und Sklerose des Stroma auf und bestand aus relativ uniformen spindeligen, fokal polygonalen Tumorzellen mit nachweisbaren globoiden intrazytoplasmatischen Einschlüssen. Trotz adjuvanter Chemo- und Radiotherapie entwickelten sich ausgedehnte Tumorrezidive und Metastasen in der Lunge und dem Thymus; der Patient verstarb 3 Jahre später. In den Tumorrezidiven und Metastasen fand sich eine Tumorprogression zu einem zellreicheren, mitotisch aktiveren Neoplasma. Immunhistochemisch zeigten die Tumorzellen eine deutlich ausgeprägte Positivität für Antikörper gegen Vimentin, Desmin und muskelspezifisches Aktin sowie eine fokal nachweisbare nukleäre Positivität für MyoD1; der Tumor zeigte keine Immunpositivität für alpha-glatt muskuläres Antigen, neurale und epitheliale Marker, sowie für CD34 und CD31. Die Differentialdiagnose dieses aggressiven Tumors im Spektrum der spindelzelligen Läsionen im Kleinkindalter wird diskutiert.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 35 (1999), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Angiosarcomatous differentiation represents the least common form of heterologous differentiation in malignant peripheral nerve sheath tumours (MPNST), and is seen most frequently in patients with neurofibromatosis type 1. More rarely, it has been reported in patients without stigmata of neurofibromatosis, or in benign nerve sheath tumours and peripheral nerves. This study was undertaken to confirm this rare association.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsFour cases of angiosarcoma arising in a peripheral nerve, in a long-standing schwannoma and in two MPNST are described. Immunohistochemical studies were performed on paraffin sections with the alkaline phosphatase–antialkaline phosphatase method. An intraneural high-grade epithelioid angiosarcoma arose in the left posterior tibial nerve of a 78-year-old man, a well to moderately differentiated angiosarcoma was seen in an ancient schwannoma of the lateral neck in a 73-year-old women, and an angiosarcoma of varying grades of differentiation developed in a recurrent MPNST in the thigh of 38-year-old man. In addition a high-grade MPNST in the axillary region of a 30-year-old man showed foci of heterologous high-grade angiosarcomatous differentiation. The neural and endothelial lines of differentiation were confirmed in each case by positive immunohistochemical staining for neural and endothelial markers, respectively. In all cases tested, the neural differentiated cells stained immunohistochemically positive for antibodies against vascular endothelial growth factor.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsThis study confirms the rare association of angiosarcoma arising in peripheral nerves, as well as in benign and maligant peripheral nerve sheath tumours.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 35 (1999), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report an example of malignant myoepithelioma of the vulva, which has not been hitherto described. We discuss the differential diagnosis and briefly review the literature.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsThe lesion was found in an 81-year-old woman as an indolent 40 mm tumour. The neoplastic cells showed a myoid, spindled, epithelioid and plasmacytoid phenotype. Hyalinization of extracellular material and myxoid changes were present. There was a partly solid and microcystic pattern and a tight cohesiveness of cells was lacking. The circumscribed multinodular tumour somewhat resembled an extrarenal rhabdoid tumour, having large tumour cells with prominent nucleoli and large amounts of acidophilic cytoplasm. Immunohistochemically, the tumour cells were immunoreactive for cytokeratin, vimentin, muscle-specific actin, alpha-smooth muscle actin, and S100 protein, but not for desmin, epithelial membrane antigen, factor VIII-related antigen, CD34 and CD31.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsThe histological and cytomorphological appearance of the tumour well as the immunohistochemical findings suggest the diagnosis of malignant myoepithelioma, possibly derived from minor vestibulary glands or ectopic breast tissue. Differential diagnoses are, in particular, extrarenal rhabdoid tumour and ‘proximal type’ epithelioid sarcoma. Differentiation is important, because the tumours show a different behaviour and prognosis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 29 (1996), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 19 (1991), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The expression of extracellular matrix (ECM) proteins (fibronectin, laminin, collagen IV) and ECM receptors of integrin type (α2β1, collagen receptor; α6 chain of the fibronectin receptor; α6 chain of the laminin receptor) were examined in normal oral squamous epithelium and in invasive areas of oral squamous cell carcinomas with various differentiation and proliferation activities (Ki-67 antigen labelling), evaluating the presence, quantity (using an image analysis system) and distribution of the integrin subunits. In the mucosa, there was uniform immunostaining for α2β1 and α6 concentrated at the cell membrane in the basal/supra basal cell zone, whereas, α5 showed a discontinuous staining of the basal cell-basement membrane interface. α2 and α6 could be visualized in all carcinomas α5 showed low expression preferentally in less differentiated carcinomas. In contrast to normal mucosa, there was an increase in α6 staining in well-differentiated carcinomas. Dedifferentiation of oral carcinomas was accompanied by an increase in cellular proliferation and with a decrease in α2β1 and α6 staining. This reduction of α6 staining was shown to be statistically significant, suggesting that this integrin may be a valuable grading parameter for oral squamous cell carcinoma.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 357 (1972), S. 299-318 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 15 einschlägigen Beobachtungen wird die Frage untersucht, ob die herdförmigen knotigen tumorartigen Bindegewebsproliferationen, die in der Submucosa des Magens auftreten können, eine einheitliche Gruppe darstellen, welches ihre Histogenese ist, worauf ihre erheblichen histologischen Strukturunterschiede beruhen, wie ihre allgemeinpathologische Einordnung zu erfolgen hat, wie die Problematik ihrer Nomenklatur zu beurteilen ist und welche Vorstellungen man sich zur Zeit über ihre Ätiologie und Pathogenese machen kann. Allen Beobachtungen ist gemeinsam eine gefäßhaltige mesenchymale Grundstruktur mit unterschiedlicher Anhäufung eosinophil granulierter Leukocyten. Auf dieser Grundlage werden zwei Typen erkennbar: der erste Typus umfaßt knotige Herdbildungen mit charakteristischen Gefäßmustern und einem faserarmen, saftreichen Bindegewebe; der zweite Typus ist durch faserreiche und wechselnd zellreiche, ebenfalls knotige Bildungen gekennzeichnet, jedoch sind in dieser Gruppe auf Grund weiterer ins Spiel tretender Merkmale drei Varianten möglich: Hinzutreten massenhafter eosinophil granulierter Leukocyten, Vorherrschen angioretikulärer Strukturen und Histiocytomähnliche Bildungen. Es handelt sich um eine einheitliche hyperplastische Reaktion des submukösen Bindegewebes — möglicherweise ausgelöst durch Mikrotraumen und Fremdkörper unter entscheidender fortdauernder Mitwirkung des Magensaftes — mit wechselhaft auftretenden und verschwindenden, d.h. örtlich und zeitlich wandelbaren und auch ineinander übergehenden Strukturen sowohl in einer und derselben als auch in verschiedenen Bildungen. Das bedingt ihre morphologische und nomenklatorische Vielfalt. Wir schlagen daher vor, sie generell als „Fibrohistiocytosen der Magenwand (mit wechselnder Gewebseosinophilie)“ den tumor-like lesions of the soft tissues bzw. den Fibromatosen der Bindegewebe als eine spezifische Sonderform des Magens zuzuordnen.
    Notes: Summary On the basis of 15 pertinent cases the authors study the problem of whether the focal nodular tumor-like connective tissue proliferations occurring in the gastric submucosa represent a homogeneous group. Insight into the histogenesis and the reasons for the different histological patterns of such lesions are sought. Possibilities for their classification within general pathology and for estimation of the problems of nomenclature are studied as well as current views on their etiology and pathogenesis. All observations reveal a fibrous mesenchymal basic structure with varying accumulations of eosinophilic granular leucocytes. On this basis two types of growth can be distinguished: the first type includes nodular focal formations with a characteristic arrangement of the vessels and a succulent connective tissue poor in fibers; the second type is also characterized by nodular growth with a varying number of cells, but because of especial specific features three varieties are possible within this group. These are characterized by: abundance of eosinophilic granular leucocytes; prevalence of angioreticular structures and histiocytoma-like structures. All phenomena represent a homogeneous hyperplastic response of the submucous connective tissue of the stomach. This may be evoked by microtraumas or by foreign bodies with a decisive continuous influence of the gastric juice. As a consequence, the structures which appear are not consistent; they come and go, varying at different sites and also at different times, and in many cases they also merge into one another within the same as well as in different lesions. This conditions their polymorphous tissue patterns and the resultant numerous terms and synonyms. Because of the phenomena described above we suggest the term fibrohistiocytosis of the gastric wall (with changeable eosinophilic infiltration). As a specific phenomenon of the stomach it should be classified in the tumor-like lesions of the soft tissues or in the fibromatoses of the connective tissue.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 388 (1980), S. 349-360 
    ISSN: 1432-2307
    Keywords: Synovial sarcoma ; Abdominal wall ; Ultrastructural cytology ; Histochemistry of synovial sarcoma ; Biphasic cellular pattern
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A synovial sarcoma of the abdominal wall in a 56-year old woman showed the typical features of this tumor type. Histologically a characteristic biphasic cellular pattern with epithelium-like cell complexes and sarcomatous spindle cell areas was found. The histochemical examination revealed that tumor cells synthesize glycoproteins and weakly acid glycosaminoglycans (mainly hyaluronic acid). Electron microscopically the tumor cells in epithelium-like cell islets were sometimes arranged in gland-like formations with microvilli at the luminal side, specialized intercellular junctions and a peripheral basement membrane-like condensation of the ground substance. There was no fundamental cytological difference between cells of epithelium-like and spindle cell areas. Generally the tumor cells imitated cells of the synovial membrane and we found no evidence for origin from cells of the nerve sheath. Because of the submicroscopic relationship and histochemical similarities of synovial sarcomas and mesotheliomas we suggest that they should be united in a group of sarcomas with possible biphasic cellular pattern, while preserving their clinicopathologic definition.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 388 (1980), S. 361-368 
    ISSN: 1432-2307
    Keywords: Vulva ; Bartholin's gland ; Leiomyoma ; Fibroma-like-pattern ; Smooth muscle cells ; Pseudoelastin ; Collagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A unique case of a 71-year old woman with an unusual fibromalike leiomyoma of the vulva in the region of the left Bartholin's gland is reported. Light microscopically the tumor resembled a fibroma, but electron microscopically the cells corresponded to modified smooth muscle cells. The great number of vessels and their intimate relation to the tumor cells is remarkable. In the intercellular space granular and fibrillar pseudoelastic material was found and thus the presence of collagen type III in addition to type I is suggested. In the region of the right Bartholin's gland a mesenchymal proliferation with similar histological features was seen but there was more resemblance to a conventional leiomyoma. The histogenesis remains obscure so that the designation of these lesions should include light microscopic and electron microscopic appearances as well as the localization.
    Type of Medium: Electronic Resource
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