Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
British journal of dermatology
110 (1984), S. 0
ISSN:
1365-2133
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
A double-blind comparison of terfenadine with placebo showed a reduction in potency of measured dermographic force-response of 67%, which is similar to that for inhibition of histamine weals by terfenadine. This and the parallel displacement of the force–response curves indicates that histamine is the main cause of dermographic wealing. Dermographic threshold and itch change together and appear to be the main determinant of the patients' subjective response. Dermographism relapsed towards its pre-treatment state during the 3 days after treatment was stopped. There was a small decrease in effect after administration of 60 mg b. d. for 47–84 days and a further small increase in response when the dose was increased to 120 mg t. d. s., but neither change was significant. None of the patients had a sedative response to the drug and terfenadine should prove useful in the treatment of wealing disorders.Terfenadine is an H1 receptor antagonist without soporific activity in doses which produce significant inhibition of histamine wealing (Huther et al., 1977; Reinberg et al., 1978; Nicholson & Stone, 1982; Ford, Krause & Shuster, in preparation). We therefore studied its effect on patients with dermographism both by objective measurement and by subjective self-assessment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2133.1984.tb07315.x
Permalink
Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |