ISSN:
0570-0833
Schlagwort(e):
Cycloaddition
;
Organolithium compounds
;
Synthetic methods
;
Chemistry
;
General Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
In the field of [3 + 2]-cycloaddition reactions, 1,3-anionic cycloadditions have now joined 1,3-dipolar cycloadditions as a second reaction type of major general importance. The cycloaddition in question has been found to occur with 2-azaallyllithium compounds, allyllithium compounds (with an electron acceptor located on C2), and 1,3-diphenylpropargyllithium. Compounds with CC, CN, NN, and CS double bonds and those with CC and CN triple bonds were found to be 1,3-anionophilic. 1,3-Anionic cycloaddition opens new routes to 1-aza-, 1,2-diaza-, 1,3-diaza-, 1,2,4-triaza-, and 1-thia-3-azacyclopentane derivatives, to pyrroles and imidazoles, as well as (and this appears to be of special importance) to cyclopentane derivatives. Currently available data attribute stereospecificity to the 1,3-anionic cycloadditions, which occupy an interesting intermediate position between 1,3-dipolar cycloadditions and transition-metal-catalyzed cyclizations. A two-step mechanism has been demonstrated in one case.
Zusätzliches Material:
8 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/anie.197406271
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