ISSN:
0018-019X
Schlagwort(e):
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Use of the ‘Zip’ reaction for the synthesis of a 53-membered polyminolactamThe synthesis of N-(39-amino-4, 8, 12, 16, 20, 24, 28, 32, 36-nonaaza-nonatriacontyl)-12-dodecanlactam (1)In ‘5’ wurden die Verbindungen 1 als 1-(39-Amino-4,8,12,16,20,24,28,32,36-nonaazanonatriacontyl)-1-azacyclotridecan-2-on, 4 als 7-Chlor-1-phthalimido-4-tosyl-4-azaheptan, 5 als 7-Jod-1-phthalimido-4-tosyl-4-azaheptan und 20 als 1,5,9,13,17,21,25,29,33,37,41-Undecaazatripentacontan-42-on bezeichnet. has been described. The formation of synthon 2 , used for the chain extension of the known 12[6] shown in Scheme 2 , is demonstrated in Scheme 1 . In presence of base (KAPA-reagent), 1 undergoes the so called ‘Zip’-reaction resulting in a ring-expansion by 40 members which leads to 20 .
Zusätzliches Material:
1 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/hlca.19790620727
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