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Digitale Medien

Retinal S-antigen immunoreactivity in medulloblastomas (1988)

Bonnin, J. M. ; Perentes, E.

Springer

Acta neuropathologica 76 (1988), S. 204-207

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Details

ISSN: 1432-0533

Schlagwort(e): S-Antigen ; Monoclonal antibodies ; Cerebellar medulloblastoma ; Photoreceptor cells

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary A series of 16 cerebellar medulloblastomas were studied immunohistochemically using a four-step immunoperoxidase (PAP) method and a monoclonal antibody (MAbA9-C6) which defines an epitope of the retinal S-antigen, a protein known to occur in retinal photoreceptor cells and pinealocytes of the pineal gland as well as in retinoblastomas, pineocytomas and pineoblastomas. Immunopositivity was demonstrated in a variable number of tumor cells in 50% of the cases. This finding may be an indication of a differentiation potential of medulloblastomas along the photoreceptor cell lineage. Alternatively, it may simply indicate the non-specificity of the retinal antigen in the neoplastic state.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00688104

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