ISSN:
1420-9071
Keywords:
Hypothalamus
;
norepinephrine
;
fever
;
pyrogen
;
polyriboinosinic acid
;
polyribocytidylic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Administration of either Poly I:Poly C (0.05–0.50 μg) or norepinephrine (2–8 μg) into the anterior hypothalamic area produced a dose-related fever in rats. The fever induced by Poly I:Poly C was attenuated after selective depletion of norepinephrine in the hypothalamus. However, selective depletion of hypothalamic norepinephrine did not affect the fever induced by intrahypothalamic norepinephrine. The data indicate that Poly I:Poly C may act to induce fever through the endogenous release of norepinephrine from the rat's hypothalamus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01974567
