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Digitale Medien

Depletion of hypothalamic norepinephrine reduces the fever induced by polyriboinosinic acid: polyribocytidylic acid (Poly I:Poly C) in rats (1989)

Liu, H. J. ; Young, C. M. ; Lin, M. T.

Springer

Cellular and molecular life sciences 45 (1989), S. 720-722

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Details

ISSN: 1420-9071

Schlagwort(e): Hypothalamus ; norepinephrine ; fever ; pyrogen ; polyriboinosinic acid ; polyribocytidylic acid

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Administration of either Poly I:Poly C (0.05–0.50 μg) or norepinephrine (2–8 μg) into the anterior hypothalamic area produced a dose-related fever in rats. The fever induced by Poly I:Poly C was attenuated after selective depletion of norepinephrine in the hypothalamus. However, selective depletion of hypothalamic norepinephrine did not affect the fever induced by intrahypothalamic norepinephrine. The data indicate that Poly I:Poly C may act to induce fever through the endogenous release of norepinephrine from the rat's hypothalamus.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01974567

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