ISSN:
1432-0584
Keywords:
T-cell leukemia
;
γ/δ receptor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Leukemic cells of a 20 year old patient, suffering from acute lymphoblastic leukemia, were characterized by surface marker and functional analysis. A significant cell population within this type of leukemia expresses concomitantly the CD4 and CD8 antigen on the same cell and might represent a new differentiation stage of T-cells with the γ/δ receptor. The leukemic cells show a distinct pattern of growth response to mitogens and lymphokines, which might correlate to their differentiation stage. Moreover, a “natural killer”-like activity can be induced in these cells by IL-2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01744133