ISSN:
1432-0711
Keywords:
Placental Protein 10
;
PP10
;
Radioimmunoassay
;
Breast Cancer
;
Genital Cancer
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary PP10, a recently characterized glycoprotein from human placenta, was studied using a specific double-antibody radioimmunoassay in the serum of about 100 volunteers and 200 cancer patients. Elevated levels (〉 20 nU/ml) were found in 87% of patients with primary breast cancer, in 100% of those with primary genital tumours and in 78% of patients with recurrent disease. PP10 was also measured in tumour extracts and in some patients with benign tumours. The serum concentration decreased within a few weeks after removal of the tumour. There were no significant correlations of the PP10 level with age, tumour size, histological grading or lymph node involvement. Sequential determinations of PP10 during cytostatic therapy sometimes showed rising levels accompany the development of metastases. PP10 can be regarded as a tumour associated protein and a tumour marker in gynaecological practice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02133801
