Electronic Resource
Springer
Research in experimental medicine
162 (1974), S. 341-346
ISSN:
1433-8580
Keywords:
Fructose
;
Purine synthesisde novo
;
Adenine nucleotides
;
Rat liver
;
Rat muscles
;
Hyperuricemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The intravenous infusion of fructose (0.7 and 2.4 g/kg/30 min) increases the incorporation of14C-glycine into rat liver adenine nucleotides significantly as compared to controls treated with 0.9% NaCl. A decrease of the total adenine nucleotide content of the livers occurs concomitantly. In contrast to its effect upon liver tissue fructose neither effects the content of adenine nucleotides nor the incorporation of glycine into these nucleotides in skeletal muscle of rats. — The results support the hypothesis that large quantities of fructose cause an increasedde novo synthesis of purine nucleotides in the liver. However, they do not as yet present clear cut evidence as to whether this is a direct effect of fructose or is secondary to the depletion of adenine nucleotides.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01851705
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