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Digitale Medien

Hyaluronic acid inhibits interleukin-1-induced superoxide anion in bovine chondrocytes (1997)

Fukuda, K. ; Takayama, M. ; Ueno, M. ; [weitere]

Springer

Inflammation research 46 (1997), S. 114-117

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Details

ISSN: 1420-908X

Schlagwort(e): Key words: Cartilage — Arthritis — Hyaluronic acid — Superoxide anion — Interleukin 1

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract. Objective: To examine the effect of hyaluronic acid (HA) on the induction of superoxide anion by IL-1 in chondrocytes. ¶Materials and Methods: Bovine articular chondrocytes were treated with different concentrations of IL-1. A chemiluminescent probe (L-012) was added to the medium and chemiluminescence detection was used to measure superoxide anion. ¶Results: IL-1 caused induction of superoxide anions in a dose-dependent manner. HA (10–100 〈mu〉g/ml) countered superoxide induction caused by 20 ng/ml of IL-1. ¶Conclusion: HA can afford protection against cartilage degradation, probably acting as a free-radical scavenger.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s000110050132

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