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Digitale Medien

Intranigral infusion of enkephalins elicits dyskinetic biting in rats (1989)

Liminga, Ulla ; Johansson, Per ; Nylander, Ingrid ; [weitere]

Springer

Psychopharmacology 99 (1989), S. 299-303

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Details

ISSN: 1432-2072

Schlagwort(e): Enkephalin analogues ; Intranigral infusions ; Dyskinetic biting ; Tardive dyskinesia ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Leu- and Metenkephalin (Lenk and Menk) and their more stable analogues d-Ala-Leu- and d-Ala-Meten-kephalin (DALenk and DAMenk) as well as d-ala-d-Leu-and d-Ala-d-Metenkephalin (DADLenk and DADMenk) were infused bilaterally into substantia nigra in awake rats and oral movements were recorded for 90 min. DADLenk and DADMenk elicited dose-dependent biting dyskinesias with a chewing rate of about 90 jaw movements/min. DALenk produced a similar but weaker effect, whereas DAMenk, Lenk and Menk were ineffective in the doses given. These findings suggest a possible enkephalinergic mechanism underlying neuroleptic-induced tardive dyskinesias.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00445547

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