ISSN:
1432-1041
Schlagwort(e):
azapropazone
;
arthritis
;
pharmacokinetics
;
synovial fluid level
;
synovial tissue level
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary The concentration-time curves of azapropazone in synovial fluid and tissues have been studied in arthritic patients after an i.v. bolus (600 mg) and under steady-state conditions. Synovial fluid and tissue samples were taken intraoperatively 0.45–60 h after administration. The azapropazone concentrations in synovial fluid, synovial tissue and plasma were correlated. The levels in synovial fluid were usually lower than corresponding plasma levels. Under steady-state conditions azapropazone did not accumulate in synovial tissues.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00607579