ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Nine edible oils or fats (hydrogenated coconut, cod liver, Wesson, linseed, olive, butter, lard, corn and cocoa-butter) were fed to Swiss albino mice for 90 days to study the effects of saturation, chain length, and essential fatty acid content on the liver. The specific oil or fat (selected for ranges in above variables) was used as the diet fat in a high-fat (28%), low-protein (8%), hypolipotropic diet. Half the animals received choline chloride (2 gm/100 gm) as a lipotropic supplement.Within the supplemented groups, ceroid pigment was limited to livers of mice fed cod liver oil. Among the unsupplemented groups, production of ceroid varied with the iodine value (IV) of the diet fat. Fats with low IV produced no pigment; intermediate IV showed ceroid distended Kupffer cells distributed throughout the hepatic lobule, while large, acellular, vacuolated masses of ceroid resulted from fats with highest IV.Hepatic liposis was minimal in supplemented groups; maximal in unsupplemented groups. Hepatic stroma was within normal limits in all groups. Production of ceroid pigment appeared to be unrelated to degree of liposis or fibrosis.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091620210
