ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Partial Synthesis of (25R)-26-Aminocholesterol and (25R)-26-Amino-5-cholestene-3β,16β -diol from DiosgeninDiosgenin acetate (1b) was converted via (25R)-5-cholestene-3β, 16β,26-triol (2a) to (25R)-5-cholestene-3β,26-diol (4a). From 4a and 2a (25R)-26-aminocholesterol (5d) and (25R)-26-amino-5-cholestene-3β,16β-diol (6e) were prepared via the tosyl-, iodo-, and phthalimido derivatives. Selective acetylation of 5d and 6e yielded the 26-(acetylamino)cholesterols 5e and 6f. The mass spectra of the amino- and (acetylamino)cholesterols are discussed.
Notes:
Diosgenin-acetat (1 b) wurde über (25R)-5-Cholesten-3β,16β,26-triol (2a) zu (25R)-5-Cholesten-3β,26-diol (4a) umgesetzt. Aus 4a und 2a wurden (25R)-26-Aminocholesterol (5d) und (25R)-26-Amino-5-cholesten-3β,16β-diol (6e) über die Tosyl-, Iod- und Phthalimido-Derivate dargestellt. Selektive Acetylierung von 5d und 6e ergab die 26-(Acetylamino)cholesterole 5e und 6f. Die Massenspektren der Amino- und (Acetylamino)cholesterole werden diskutiert.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19791120736
